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The properties of a bundle of grafted semi-flexible living filaments in ideal solution facing an obstacle wall, under supercritical conditions, are explored. For this purpose, we make use of the discrete wormlike chain model characterized…

Soft Condensed Matter · Physics 2013-10-18 Jean-Paul Ryckaert , Sanoop Ramachandran

We establish the Statistical Mechanics framework for a bundle of Nf living and uncrosslinked actin filaments in a supercritical solution of free monomers pressing against a mobile wall. The filaments are anchored normally to a fixed planar…

Biological Physics · Physics 2016-07-27 Alessia Perilli , Carlo Pierleoni , Giovanni Ciccotti , Jean Paul Ryckaert

In various cellular processes, biofilaments like F-actin and F-tubulin are able to exploit chemical energy associated to polymerization to perform mechanical work against an external load. The force-velocity relationship quantitatively…

Statistical Mechanics · Physics 2018-04-04 Alessia Perilli , Carlo Pierleoni , Giovanni Ciccotti , Jean-Paul Ryckaert

We develop a model to describe the force generated by the polymerization of an array of parallel biofilaments. The filaments are assumed to be coupled only through mechanical contact with a movable barrier. We calculate the filament density…

Statistical Mechanics · Physics 2015-05-20 K. Tsekouras , D. Lacoste , K. Mallick , J. -F. Joanny

The dynamic behavior of bundles of actin filaments growing against a loaded obstacle is investigated through a generalized version of the standard multi filaments Brownian Ratchet model in which the (de)polymerizing filaments are treated…

Biological Physics · Physics 2019-05-22 Alessia Perilli , Carlo Pierleoni , Jean-Paul Ryckaert

We consider a single living semi-flexible filament with persistence length l_p in chemical equilibrium with a solution of free monomers at fixed monomer chemical potential mu_1 and fixed temperature T. While one end of the filament is…

Biological Physics · Physics 2015-10-28 Carlo Pierleoni , Giovanni Ciccotti , Jean-Paul Ryckaert

We use Brownian dynamics simulations and theory to study the over-damped spatiotemporal dynamics and pattern formation in a fluid-permeated array of equally spaced, active, elastic filaments that are pinned at one end and free at the other.…

Soft Condensed Matter · Physics 2024-12-31 Sonu Karayat , Prashant K. Purohit , L. Mahadevan , Arvind Gopinath , Raghunath Chelakkot

Cells moving on a two dimensional substrate generate motion by polymerizing actin filament networks inside a flat membrane protrusion. New filaments are generated by branching off existing ones, giving rise to branched network structures.…

Biological Physics · Physics 2015-06-29 Mohammadhosein Razbin , Martin Falcke , Panayotis Benetatos , Annette Zippelius

We investigate the force generation by polymerizing bundles of filaments, which form because of short-range attractive filament interactions. We show that bundles can generate forces by a zipping mechanism, which is not limited by buckling…

Soft Condensed Matter · Physics 2012-05-02 Torsten Kuehne , Reinhard Lipowsky , Jan Kierfeld

We present a statistical mechanical study of stiff polymers, motivated by experiments on actin filaments and the considerable current interest in polymer networks. We obtain simple, approximate analytical forms for the force-extension…

Soft Condensed Matter · Physics 2009-11-13 Abhijit Ghosh , Joseph Samuel , Supurna Sinha

Filopodia are bundles of actin filaments that extend out ahead of the leading edge of a crawling cell to probe its upcoming environment. {\it In vitro} experiments [D. Vignjevic {\it et al.}, J. Cell Biol. {\bf 160}, 951 (2003)] have…

Subcellular Processes · Quantitative Biology 2010-05-14 K. -C. Lee , A. Gopinathan , J. M. Schwarz

To theoretically understand force generation properties of actin filaments, many models consider growing filaments pushing against a movable obstacle or barrier. In order to grow, the filaments need space and hence it is necessary to move…

Biological Physics · Physics 2019-02-19 Raj Kumar Sadhu , Sakuntala Chatterjee

We study force generation by a set of parallel actin filaments growing against a non-rigid obstacle, in presence of an external load. The filaments polymerize by either moving the whole obstacle, with a large energy cost, or by causing…

Subcellular Processes · Quantitative Biology 2016-06-27 Raj Kumar Sadhu , Sakuntala Chatterjee

We investigate the dynamics of a single semiflexible filament, under the action of a compressing force, using numerical simulations and scaling arguments. The force is applied along the end to end vector at one extremity of the filament,…

Soft Condensed Matter · Physics 2009-11-07 P. Ranjith , P. B. Sunil Kumar

We study the force generation by a set of parallel actin filaments growing against an elastic membrane. The elastic membrane tries to stay flat and any deformation from this flat state, either caused by thermal fluctuations or due to…

Biological Physics · Physics 2018-03-20 Raj Kumar Sadhu , Sakuntala Chatterjee

The entropic force exerted by the Brownian fluctuations of a grafted semiflexible polymer upon a rigid smooth wall are calculated both analytically and by Monte Carlo simulations. Such forces are thought to play an important role for…

Soft Condensed Matter · Physics 2007-05-23 Azam Gholami , Jan Wilhelm , Erwin Frey

We examine the nonequilibrium production of topological defects -- braids -- in semiflexible filament bundles under cycles of compression and tension. During these cycles, the period of compression facilitates the thermally activated pair…

Soft Condensed Matter · Physics 2021-05-28 Valentin M. Slepukhin , Alex J. Levine

{Filaments are ubiquitous in the interstellar medium as recently emphasized by Herschel, yet their physical origin remains elusive} {It is therefore important to understand the physics of molecular clouds to investigate how filaments form…

Astrophysics of Galaxies · Physics 2015-06-16 Patrick Hennebelle

We investigate stall force and polymerization kinetics of rigid protofilaments in a microtubule or interacting filaments in bundles under an external load force in the framework of a discrete growth model. We introduce the concecpt of…

Statistical Mechanics · Physics 2011-02-11 Jaroslaw Krawczyk , Jan Kierfeld

Two counter-propagating cool and equally dense electron beams are modelled with particle-in-cell (PIC) simulations. The electron beam filamentation instability is examined in one spatial dimension, which is an approximation for a…

Plasma Physics · Physics 2015-05-13 M. E. Dieckmann , I. Kourakis , M. Borghesi , G. Rowlands
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