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Myopia, or nearsightedness, is the most common eye disorder, resulting primarily from excess elongation of the eye. The etiology of myopia, although known to be complex, is poorly understood. Here we report the largest ever genome-wide…

Feature discovery from complex unstructured data is fundamentally a reasoning problem: it requires identifying abstractions that are predictive of a target outcome while avoiding leakage, proxies, and post-outcome signals. With the…

The Great Filter hypothesis proposes that the emergence of technological societies capable of interstellar travel depends on a small number of exceptionally hard and highly improbable steps. Traditional versions of this hypothesis enumerate…

This paper proposes a new approach to Machine Learning (ML) that focuses on unsupervised continuous context-dependent learning of complex patterns. Although the proposal is partly inspired by some of the current knowledge about the…

Neural and Evolutionary Computing · Computer Science 2024-05-07 Valentin Puente Varona

Learning in the brain is local and unsupervised (Hebbian). We derive the foundations of an effective human language model inspired by these microscopic constraints. It has two parts: (1) a hierarchy of neurons which learns to tokenize words…

Computation and Language · Computer Science 2025-03-05 P. Myles Eugenio

Self-reflection -- the ability of a large language model (LLM) to revisit, evaluate, and revise its own reasoning -- has recently emerged as a powerful behavior enabled by reinforcement learning with verifiable rewards (RLVR). While…

Machine Learning · Computer Science 2025-06-17 Xudong Zhu , Jiachen Jiang , Mohammad Mahdi Khalili , Zhihui Zhu

According to the "hard-steps" model, the origin of humanity required "successful passage through a number of intermediate steps" (so-called "hard" or "critical" steps) that were intrinsically improbable with respect to the total time…

Populations and Evolution · Quantitative Biology 2025-02-18 Daniel B. Mills , Jennifer L. Macalady , Adam Frank , Jason T. Wright

Large language models (LLMs) have significantly improved their reasoning capabilities; however, they still struggle with complex multi-step mathematical problem-solving due to error propagation, lack of self-correction, and limited…

Machine Learning · Computer Science 2025-03-10 Joykirat Singh , Tanmoy Chakraborty , Akshay Nambi

Despite their strong performance on reasoning tasks, large reasoning models (LRMs) often suffer from overthinking, producing unnecessarily long outputs and incurring high end-to-end latency, a significant limitation to their real-world…

Artificial Intelligence · Computer Science 2025-10-22 Rubing Yang , Huajun Bai , Song Liu , Guanghua Yu , Runzhi Fan , Yanbin Dang , Jiejing Zhang , Kai Liu , Jianchen Zhu , Peng Chen

Real-time Spoken Language Models (SLMs) struggle to leverage Chain-of-Thought (CoT) reasoning due to the prohibitive latency of generating the entire thought process sequentially. Enabling SLMs to think while speaking, similar to humans, is…

Computation and Language · Computer Science 2026-05-12 Donghang Wu , Haoyang Zhang , Jun Chen , Xiangyu , Zhang , Hexin Liu , Eng Siong Chng , Fei Tian , Xuerui Yang , Xiangyu Zhang , Daxin Jiang , Gang Yu

Recent advancements in large reasoning models (LRMs) have significantly enhanced language models' capabilities in complex problem-solving by emulating human-like deliberative thinking. However, these models often exhibit overthinking (i.e.,…

Artificial Intelligence · Computer Science 2025-06-19 Weixiang Zhao , Jiahe Guo , Yang Deng , Xingyu Sui , Yulin Hu , Yanyan Zhao , Wanxiang Che , Bing Qin , Tat-Seng Chua , Ting Liu

Large Language Models (LLMs) have unveiled remarkable capabilities in understanding and generating both natural language and code, but LLM reasoning is prone to hallucination and struggle with complex, novel scenarios, often getting stuck…

Neural and Evolutionary Computing · Computer Science 2025-05-12 Antonio Jimeno Yepes , Pieter Barnard

People's decisions about how to allocate their limited computational resources are essential to human intelligence. An important component of this metacognitive ability is deciding whether to continue thinking about what to do and move on…

Artificial Intelligence · Computer Science 2022-01-04 Ruiqi He , Yash Raj Jain , Falk Lieder

The Hopfield recurrent neural network is a classical auto-associative model of memory, in which collections of symmetrically-coupled McCulloch-Pitts neurons interact to perform emergent computation. Although previous researchers have…

Adaptation and Self-Organizing Systems · Physics 2015-06-09 Christopher Hillar , Ngoc M. Tran

Brain aging trajectories differ between males and females, yet the genetic factors underlying these differences remain underexplored. Using structural MRI and genotyping data from 40,940 UK Biobank participants (aged 45-83), we computed…

How the information microscopically processed by individual neurons is integrated and used in organizing the behavior of an animal is a central question in neuroscience. The coherence of neuronal dynamics over different scales has been…

Disordered Systems and Neural Networks · Physics 2020-03-11 Takashi Hayakawa , Tomoki Fukai

Our view of the universe of genomic regions harboring various types of candidate human-specific regulatory sequences (HSRS) has been markedly expanded in recent years. To infer the evolutionary origins of loci harboring HSRS, analyses of…

Genomics · Quantitative Biology 2025-12-30 Gennadi Glinsky

Real-time coupling of cell cultures to neuromorphic circuits necessitates a neuromorphic network that replicates biological behaviour both on a per-neuron and on a population basis, with a network size comparable to the culture. We present…

Reinforcement learning (RL) enables adaptive behavior across species via reward prediction errors (RPEs), but the neural origins of species-specific adaptability remain unknown. Integrating RL modeling, transcriptomics, and neuroimaging…

Neurons and Cognition · Quantitative Biology 2025-12-12 Tian Sang , Yichun Huang , Fangwei Zhong , Miao Wang , Shiqi Yu , Jiahui Li , Yuanjing Feng , Yizhou Wang , Kwok Sze Chai , Ravi S. Menon , Meiyun Wang , Fang Fang , Zheng Wang

Word similarities affect language acquisition and use in a multi-relational way barely accounted for in the literature. We propose a multiplex network representation of this mental lexicon of word similarities as a natural framework for…

Physics and Society · Physics 2018-01-23 Massimo Stella , Nicole M. Beckage , Markus Brede , Manlio De Domenico