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Bioreactors are widely used in many industries to generate a range of products using various host cells e.g., yeast, insect, and mammalian cells. Depending on the process, product, and host cell, some bioreactors exhibit sustained periodic…

Quantitative Methods · Quantitative Biology 2023-06-29 Pavan Inguva , Krystian Ganko , Alexis B. Dubs , Richard D. Braatz

A simple model of oscillator chain with dynamical traps and additive white noise is considered. Its dynamics was studied numerically. As demonstrated, when the trap effect is pronounced nonequilibrium phase transitions of a new type arise.…

Statistical Mechanics · Physics 2009-11-10 Ihor Lubashevsky , Reinhard Mahnke , Morteza Hajimahmoodzadeh , Albert Katsnelson

Optical communications technology has made enormous and steady progress for several decades, providing the key resource in our increasingly information-driven society and economy. Much of this progress has been in finding innovative ways to…

Optics · Physics 2015-06-15 D. J. Richardson , J. M. Fini , L E. Nelson

The precision of concentration sensing is improved when cells communicate. Here we derive the physical limits to concentration sensing for cells that communicate over short distances by directly exchanging small molecules (juxtacrine…

Biological Physics · Physics 2017-03-15 Sean Fancher , Andrew Mugler

The widespread development and use of neural networks have significantly enriched a wide range of computer algorithms and promise higher speed at lower cost. However, the imitation of neural networks by means of modern computing substrates…

Adaptation and Self-Organizing Systems · Physics 2024-08-28 Anna Zakharova , Vladimir V. Semenov

In this paper, multiplexing of discrete chaotic signals in the presence of noise is investigated. Existing methods are based on chaotic synchronization which is susceptible to noise and parameter mismatch. Furthermore, these methods fail…

Chaotic Dynamics · Physics 2015-05-13 Nithin Nagaraj , Prabhakar G. Vaidya

We introduce a stochastic model of coupled genetic oscillators in which chains of chemical events involved in gene regulation and expression are represented as sequences of Poisson processes. We characterize steady states by their…

Biological Physics · Physics 2018-03-28 David J. Jörg , Luis G. Morelli , Frank Jülicher

Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and cytoplasmic processes to control cell responses. Genetic mutations in signaling network components are frequently…

Molecular Networks · Quantitative Biology 2021-06-15 Michael A. Kochen , Steven S. Andrews , H. Steven Wiley , Song Feng , Herbert M. Sauro

When a noisy communication channel is used multiple times, the errors occurring at different times generally exhibit correlations. Classically, these correlations do not affect the evolution of individual particles: a single classical…

Quantum Physics · Physics 2021-12-07 Hlér Kristjánsson , Wenxu Mao , Giulio Chiribella

We investigate the efficient transmission and processing of weak, subthreshold signals in a realistic neural medium in the presence of different levels of the underlying noise. Assuming Hebbian weights for maximal synaptic conductances --…

Biological Physics · Physics 2015-08-19 Joaquin J. Torres , Irene Elices , J. Marro

Oscillatory media can exhibit the coexistence of synchronized and desynchronized regions, so-called chimera states, for uniform parameters and symmetrical coupling. In a phase-balanced chimera state, where the totals of synchronized and…

Chaotic Dynamics · Physics 2015-05-22 Sindre W. Haugland , Lennart Schmidt , Katharina Krischer

Electrical engineering and molecular programming share many of the same mathematical foundations. In this paper, we show how to send multiple signals through a single pair of chemical species using modulation and demodulation techniques…

Emerging Technologies · Computer Science 2020-09-16 Titus H. Klinge , James I. Lathrop

Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be…

Subcellular Processes · Quantitative Biology 2017-04-12 Gabriele Micali , Gerardo Aquino , David M. Richards , Robert G. Endres

Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing…

Cell Behavior · Quantitative Biology 2024-08-27 Alan Givré , Alejandro Colman-Lerner , Silvina Ponce Dawson

A recurrent idea in the study of complex systems is that optimal information processing is to be found near bifurcation points or phase transitions. However, this heuristic hypothesis has few (if any) concrete realizations where a standard…

Neurons and Cognition · Quantitative Biology 2007-05-23 Osame Kinouchi , Mauro Copelli

We analyze a class of network motifs in which a short, two-node positive feed- back motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can undergo a bifurcation to a state where a stable fixed point…

Molecular Networks · Quantitative Biology 2012-09-10 Weihan Li , Sandeep Krishna , Simone Pigolotti , Namiko Mitarai , Mogens H. Jensen

Bacteria track chemical gradients using a biased random walk, a process called chemotaxis. Experiments suggest that bacteria also communicate during this process. Using a mathematical model, we find that sufficiently strong communication…

Biological Physics · Physics 2025-12-18 Soutick Saha , Sean Fancher , Andrew Mugler

Oscillatory systems with time-delayed pulsatile feedback appear in various applied and theoretical research areas, and received a growing interest in the last years. For such systems, we report a remarkable scenario of destabilization of a…

Chaotic Dynamics · Physics 2015-05-28 Vladimir Klinshov , Leonhard Lücken , Dmitry Shchapin , Vladimir Nekorkin , Serhiy Yanchuk

Optical communication systems are able to send the information from one user to another in light beams that travel through the free space or optical fibers, therefore how to send larger amounts of information in smaller periods of time is a…

Quantum Physics · Physics 2018-03-07 Wen-Tan Fang , Yin-Hai Li , Zhi-Yuan Zhou , Li-Xin Xu , Guang-Can Guo , Bao-Sen Shi

The action potential propagating in a nerve fibre generates accompanying mechanical and thermal effects. The whole signal is therefore an ensemble which includes primary and secondary components. The primary components of a signal are the…

Biological Physics · Physics 2018-12-14 Jüri Engelbrecht , Kert Tamm , Tanel Peets