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Following some recent works, we investigate the problem of optimising the total population size for logistic diffusive models with respect to resources distributions. Using the spatially heterogeneous Fisher-KPP equation, we obtain a…

Optimization and Control · Mathematics 2020-10-22 Idriss Mazari , Domenec Ruiz-Balet

We give an exact solution to the Kolmogorov equation describing genetic drift for an arbitrary number of alleles at a given locus. This is achieved by finding a change of variable which makes the equation separable, and therefore reduces…

Populations and Evolution · Quantitative Biology 2015-05-26 G. Baxter , R. A. Blythe , A. J. McKane

Anomalous diffusion is an established phenomenon but still a theoretical challenge in non-equilibrium statistical mechanics. Physical models are built incrementally, and the most recent and most general family is based on the fractional…

Probability · Mathematics 2025-07-23 Christian Bender , Yana A. Butko , Mirko D'Ovidio , Gianni Pagnini

Devising optimal interventions for constraining stochastic systems is a challenging endeavour that has to confront the interplay between randomness and nonlinearity. Existing methods for identifying the necessary dynamical adjustments…

Statistical Mechanics · Physics 2022-10-18 Dimitra Maoutsa , Manfred Opper

Inferring the driving equations of a dynamical system from population or time-course data is important in several scientific fields such as biochemistry, epidemiology, financial mathematics and many others. Despite the existence of…

Machine Learning · Computer Science 2020-12-10 Anastasios Tsourtis , Yannis Pantazis , Ioannis Tsamardinos

In a convergence of machine learning and biology, we reveal that diffusion models are evolutionary algorithms. By considering evolution as a denoising process and reversed evolution as diffusion, we mathematically demonstrate that diffusion…

Neural and Evolutionary Computing · Computer Science 2026-05-12 Yanbo Zhang , Benedikt Hartl , Hananel Hazan , Michael Levin

The purpose of this paper is to study optimal control of conditional McKean-Vlasov (mean-field) stochastic differential equations with jumps (conditional McKean-Vlasov jump diffusions, for short). To this end, we first prove a stochastic…

Probability · Mathematics 2023-01-10 Nacira Agram , Bernt Oksendal

Path-wise observables--functionals of stochastic trajectories--are at the heart of time-average statistical mechanics and are central to thermodynamic inequalities such as uncertainty relations, speed limits, and correlation-bounds. They…

Statistical Mechanics · Physics 2026-04-21 Lars Torbjørn Stutzer , Cai Dieball , Aljaž Godec

An open question in systems and computational neuroscience is how neural circuits accumulate evidence towards a decision. Fitting models of decision-making theory to neural activity helps answer this question, but current approaches limit…

Neurons and Cognition · Quantitative Biology 2020-01-15 David M. Zoltowski , Jonathan W. Pillow , Scott W. Linderman

A considerable number of systems have recently been reported in which Brownian yet non-Gaussian dynamics was observed. These are processes characterised by a linear growth in time of the mean squared displacement, yet the probability…

Statistical Mechanics · Physics 2018-11-26 V. Sposini , A. V. Chechkin , F. Seno , G. Pagnini , R. Metzler

Dynamics among central sources (hubs) providing a resource and large number of components enjoying and contributing to this resource describes many real life situations. Modeling, controlling, and balancing this dynamics is a general…

Data Analysis, Statistics and Probability · Physics 2020-09-22 Inbar Seroussi , Nir Sochen

Diffusion models have achieved impressive success in high-fidelity image generation but suffer from slow sampling due to their inherently iterative denoising process. While recent one-step methods accelerate inference by learning direct…

Machine Learning · Computer Science 2025-10-15 Hanru Bai , Weiyang Ding , Difan Zou

We consider a population dynamics model coupling cell growth to a diffusion in the space of metabolic phenotypes as it can be obtained from realistic constraints-based modelling. In the asymptotic regime of slow diffusion, that coincides…

Populations and Evolution · Quantitative Biology 2017-02-17 Daniele De Martino , Davide Masoero

The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit…

Populations and Evolution · Quantitative Biology 2015-06-30 Oskar Hallatschek , Lukas Geyrhofer

Diffusion models (DMs) are a class of generative machine learning methods that sample a target distribution by transforming samples of a trivial (often Gaussian) distribution using a learned stochastic differential equation. In standard…

Statistical Mechanics · Physics 2024-08-15 Luke Causer , Grant M. Rotskoff , Juan P. Garrahan

Deriving evolution equations accounting for both anomalous diffusion and reactions is notoriously difficult, even in the simplest cases. In contrast to normal diffusion, reaction kinetics cannot be incorporated into evolution equations…

Statistical Mechanics · Physics 2020-10-23 Sean D Lawley

In these lecture notes, we explore the mathematical preliminaries and foundational concepts that connect stochastic processes with partial differential equations. We begin by investigating Brownian motion, which serves as a model for random…

Probability · Mathematics 2025-09-15 Helder Rojas

The process of `Evolutionary Diffusion', i.e. reproduction with local mutation but without selection in a biological population, resembles standard Diffusion in many ways. However, Evolutionary Diffusion allows the formation of local peaks…

Populations and Evolution · Quantitative Biology 2007-05-23 Daniel John Lawson , Henrik Jeldtoft Jensen

We study a model of an infinite system of point particles in $\mathds{R}^d$ performing random jumps with attraction. The system's states are probability measures on the space of particle configurations, and their evolution is described by…

Mathematical Physics · Physics 2016-12-28 Yuri Kozitsky

Seizure activity is a ubiquitous and pernicious pathophysiology that, in principle, should yield to mathematical treatments of (neuronal) ensemble dynamics - and therefore interventions on stochastic chaos. A seizure can be characterised as…

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