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Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

A simplicial complex is a generalization of a graph: a collection of n-ary relationships (instead of binary as the edges of a graph), named simplices. In this paper, we develop a new tool to study the structure of simplicial complexes: we…

Social and Information Networks · Computer Science 2021-02-16 Giulia Preti , Gianmarco De Francisci Morales , Francesco Bonchi

The CUR decomposition is a technique for low-rank approximation that selects small subsets of the columns and rows of a given matrix to use as bases for its column and rowspaces. It has recently attracted much interest, as it has several…

Numerical Analysis · Mathematics 2022-06-06 Yijun Dong , Per-Gunnar Martinsson

In medical imaging, chromosome straightening plays a significant role in the pathological study of chromosomes and in the development of cytogenetic maps. Whereas different approaches exist for the straightening task, typically geometric…

Computer Vision and Pattern Recognition · Computer Science 2021-10-20 Sifan Song , Daiyun Huang , Yalun Hu , Chunxiao Yang , Jia Meng , Fei Ma , Frans Coenen , Jiaming Zhang , Jionglong Su

Finding a suitable data representation for a specific task has been shown to be crucial in many applications. The success of subspace clustering depends on the assumption that the data can be separated into different subspaces. However,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-21 Zhengrui Ma , Zhao Kang , Guangchun Luo , Ling Tian

Topological Data Analysis has grown in popularity in recent years as a way to apply tools from algebraic topology to large data sets. One of the main tools in topological data analysis is persistent homology. This paper uses undergraduate…

Algebraic Topology · Mathematics 2024-06-26 Cheyne Glass , Elizabeth Vidaurre

Topological structures in image data, such as connected components and loops, play a crucial role in understanding image content (e.g., biomedical objects). % Despite remarkable successes of numerous image processing methods that rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Pengfei Gu , Hongxiao Wang , Yejia Zhang , Huimin Li , Chaoli Wang , Danny Chen

We introduce a new regression framework designed to deal with large-scale, complex data that lies around a low-dimensional manifold with noises. Our approach first constructs a graph representation, referred to as the skeleton, to capture…

Machine Learning · Computer Science 2026-03-17 Zeyu Wei , Yen-Chi Chen

Automated axon tracing via fully supervised learning requires large amounts of 3D brain imagery, which is time consuming and laborious to obtain. It also requires expertise. Thus, there is a need for more efficient segmentation and…

Image and Video Processing · Electrical Eng. & Systems 2023-11-08 Nina I. Shamsi , Alex S. Xu , Lars A. Gjesteby , Laura J. Brattain

Recovering point clouds involves the sequential process of sampling and restoration, yet existing methods struggle to effectively leverage both topological and geometric attributes. To address this, we propose an end-to-end architecture…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Kaiyue Zhou , Zelong Tan , Hongxiao Wang , Ya-Li Li , Shengjin Wang

Graph convolutional networks (GCNs) have recently achieved great empirical success in learning graph-structured data. To address its scalability issue due to the recursive embedding of neighboring features, graph topology sampling has been…

Machine Learning · Computer Science 2023-12-12 Hongkang Li , Meng Wang , Sijia Liu , Pin-Yu Chen , Jinjun Xiong

Information networks are becoming increasingly popular to capture complex relationships across various disciplines, such as social networks, citation networks, and biological networks. The primary challenge in this domain is measuring…

Algebraic Topology · Mathematics 2019-07-23 Mehmet Emin Aktas , Esra Akbas , Ahmed El Fatmaoui

We consider the problem of extracting curve skeletons of three-dimensional, elongated objects given a noisy surface, which has applications in agricultural contexts such as extracting the branching structure of plants. We describe an…

Computer Vision and Pattern Recognition · Computer Science 2018-03-20 Amy Tabb , Henry Medeiros

We propose a novel probabilistic dimensionality reduction framework that can naturally integrate the generative model and the locality information of data. Based on this framework, we present a new model, which is able to learn a smooth…

Machine Learning · Statistics 2016-10-18 Li Wang

Assume that a finite set of points is randomly sampled from a subspace of a metric space. Recent advances in computational topology have provided several approaches to recovering the geometric and topological properties of the underlying…

Algebraic Topology · Mathematics 2021-01-29 Peter Bubenik , Peter T. Kim

Topological data analysis (TDA) detects geometric structure in biological data. However, many TDA algorithms are memory intensive and impractical for massive datasets. Here, we introduce a statistical protocol that reduces TDA's memory…

Quantitative Methods · Quantitative Biology 2025-09-05 Andrew J. Stier , Naichen Shi , Raed Al Kontar , Chad Giusti , Marc G. Berman

Graph embeddings play a critical role in graph representation learning, allowing machine learning models to explore and interpret graph-structured data. However, existing methods often rely on opaque, high-dimensional embeddings, limiting…

Machine Learning · Computer Science 2025-11-26 Astrit Tola , Funmilola Mary Taiwo , Cuneyt Gurcan Akcora , Baris Coskunuzer

Persistent homology is a popular tool in Topological Data Analysis. It provides numerical characteristics of data sets which reflect global geometric properties. In order to be useful in practice, for example for feature generation in…

Computational Geometry · Computer Science 2020-02-17 Boris Goldfarb

Accurately restoring topology is both challenging and crucial in tubular structure extraction tasks, such as blood vessel segmentation and road network extraction. Diverging from traditional approaches based on pixel-level classification,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Zhao Zhang , Ziwei Zhao , Dong Wang , Liwei Wang

Many computational algorithms applied to geometry operate on discrete representations of shape. It is sometimes necessary to first simplify, or coarsen, representations found in modern datasets for practicable or expedited processing. The…

Computational Geometry · Computer Science 2023-02-10 Alexandros Dimitrios Keros , Kartic Subr
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