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Since the invention of digital cameras there has been a concerted drive towards detector arrays with higher spatial resolution. Microscanning is a technique that provides a final higher resolution image by combining multiple images of a…

Microdosimetry investigates the energy deposition of ionizing radiation at microscopic scales, beyond the assessment capabilities of macroscopic dosimetry. This contributes to an understanding of the biological response in radiobiology,…

On-chip spectroscopy that could realize real-time fingerprinting with label-free and high-throughput detection of trace molecules is one of the 'holy grails" of sensing. Such miniaturized spectrometers would greatly enable applications in…

CMOS pixel sensors (CPS) represent a novel technological approach to building charged particle detectors. CMOS processes allow to integrate a sensing volume and readout electronics in a single silicon die allowing to build sensors with a…

Spectral imaging enables spatially-resolved identification of materials in remote sensing, biomedicine, and astronomy. However, acquisition times require balancing spectral and spatial resolution with signal-to-noise. Hyperspectral imaging…

Computer Vision and Pattern Recognition · Computer Science 2020-03-17 Nguyen Tran , Rupali Mankar , David Mayerich , Zhu Han

Compared to single-source imaging systems, dual-source imaging systems equipped with two cross-distributed scanning beams significantly enhance temporal resolution and capture more comprehensive object scanning information. Nevertheless,…

Medical Physics · Physics 2025-03-19 Jianing Sun , Jigang Duan , Guangyin Li , Xu Jiang , Xing Zhao

While electron microscopy offers crucial atomic-resolution insights into structure-property relationships, radiation damage severely limits its use on beam-sensitive materials like proteins and 2D materials. To overcome this challenge, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zifei Wang , Zian Mao , Xiaoya He , Xi Huang , Haoran Zhang , Chun Cheng , Shufen Chu , Tingzheng Hou , Xiaoqin Zeng , Yujun Xie

Capturing biological specimens at large scales with sub-micron resolution is crucial for biomedical research, but conventional cameras often can't handle the pixel requirements. While most microscopes use motorized stages to move samples…

Optics · Physics 2025-03-28 Charlie Kersuzan , Aymerick Bazin , Amaury Badon

Space-based gamma-ray telescopes such as the Fermi Large Area Telescope have used single sided silicon strip detectors to measure the position of charged particles produced by incident gamma rays with high resolution. At energies in the…

A commercial, position-sensitive ion detector was used for the first time for the time-of-flight ion-cyclotron resonance detection technique in Penning trap mass spectrometry. In this work, the characteristics of the detector and its…

Nuclear Experiment · Physics 2009-09-10 G. Eitel , M. Block , A. Czasch , M. Dworschak , S. George , O. Jagutzki , J. Ketelaer , J. Ketter , Sz. Nagy , D. Rodriguez , C. Smorra , K. Blaum

The development of a multiple-channel lock-in optical spectrometer (LIOS) is presented, which enables parallel phase-sensitive detection at the output of an optical spectrometer. The light intensity from a spectrally broad source is…

Other Condensed Matter · Physics 2009-11-10 P. S. Fodor , S. Rothenberger , J. Levy

The usage of a GaAsP (gallium arsenide phosphide) photomultiplier for microscopical imaging allows the evaluation of low-light luminescent objects. We designed a setup for collecting a confocal microscopic image signal, which is divided…

Confocal microscopy, a critical advancement in optical imaging, is widely applied because of its excellent anti-noise ability. However, it has low imaging efficiency and can cause phototoxicity. Optical-sectioning structured illumination…

Optics · Physics 2024-05-27 Weishuai Zhou , Manhong Yao , Xi Lin , Quan Yu , Junzheng Peng , Jingang Zhong

We report our detailed investigation of high-resolution imaging using secondary electrons (SE) with a subnanometer probe in an aberration-corrected transmission electron microscope, Hitachi HD2700C. This instrument also allows us to acquire…

Materials Science · Physics 2010-08-31 H. Inada , D. Su , R. F. Egerton , M. Konno , L. Wu , J. Ciston , J. Wall , Y. Zhu

To meet the challenges of high-resolution molecular spectroscopy, increasingly sophisticated spectroscopic techniques were developed. For a long time FTIR and laser-based spectroscopies were used for these studies. The recent development of…

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

A universal methodology for coding-decoding the complex amplitude field of an imaged sample in coherent microscopy is presented, where no restrictions on any of the two interferometric beams are required. Thus, the imaging beam can be…

Pump-probe microscopy is an emerging nonlinear imaging technique based on high repetition rate lasers and fast intensity modulation. Here we present new methods for pump-probe microscopy that keep the beam intensity constant and instead…

Optics · Physics 2021-04-07 Jun Jiang , David Grass , Yue Zhou , Warren S. Warren , Martin C. Fischer

Mid-infrared spectroscopy offers powerful label-free molecular analysis capabilities but faces significant challenges when analyzing complex biological samples. Here, we present a transformative surface-enhanced infrared absorption…