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Sub-nm resolution images can be achieved by Atomic Force Microscopy (AFM) on samples that are deposited on hard substrates. However, it is still extremely challenging to image soft interfaces, such as biological membranes, due to the…

Nanophotonics offers a promising range of applications spanning from the development of efficient solar cells to quantum communications and biosensing. However, the ability to efficiently couple fluorescent emitters with nanostructured…

Scanning nitrogen-vacancy (NV) center electrometry has shown potential for quantitative quantum imaging of electric fields at the nanoscale. However, achieving nanoscale spatial resolution remains a challenge since employing gradiometry to…

Quantum Physics · Physics 2025-09-16 Zhi Cheng , Zhiwei Yu , Mengqi Wang , Lingfeng Yang , Zihao Cui , Ya Wang , Pengfei Wang

Spatial resolution of most imaging devices is fundamentally restricted by diffraction. This limitation is manifested in the loss of high spatial frequency information contained in evanescent waves. As a result, conventional far-field optics…

Optics · Physics 2010-03-16 Leonid Alekseyev , Evgenii Narimanov , Jacob Khurgin

An atomic force microscope~(AFM) tip, with a few nm-thick noble metal coating, gives rise to strong electric-field at the near-field of tip apex, i.e. hot spot, when illuminated with a beam of light linearly polarized in the axial…

Mesoscale and Nanoscale Physics · Physics 2019-12-10 Ramazan Sahin , Mehmet Gunay , Alpan Bek , Mehmet Emre Tasgin

Nano-NMR spectroscopy with nitrogen-vacancy centers holds the potential to provide high resolution spectra of minute samples. This is likely to have important implications for chemistry, medicine and pharmaceutical engineering. One of the…

Quantum Physics · Physics 2020-06-23 Daniel Cohen , Ramil Nigmatullin , Matan Eldar , Alex Retzker

A major open challenge in neuroscience is the ability to measure and perturb neural activity in vivo from well-defined neural sub-populations at cellular resolution anywhere in the brain. However, limitations posed by scattering and…

Biological Physics · Physics 2017-11-10 Shay Ohayon , Antonio Miguel Caravaca-Aguirre , Rafael Piestun , James J. DiCarlo

Acoustic-resolution photoacoustic microscopy (AR-PAM) is a promising tool for microvascular imaging. In the focal region, resolution of AR-PAM is determined by the ultrasound transducer and ultimately limited by acoustic diffraction. In the…

Image and Video Processing · Electrical Eng. & Systems 2021-11-22 Fei Feng , Siqi Liang , Sung-Liang Chen

We use fluorescent nanospheres as scalar detectors for the electric-field intensity in order to probe the near-field of an optical tip used in aperture-type near-field scanning optical microscopy (NSOM). Surprisingly, the recorded…

Optics · Physics 2007-05-23 A. Drezet , M. J. Nasse , S. Huant , J. C. Woehl

Spatial effects of interference and interaction of light modes in the subwavelength part of the near-field optical microscopy probe have been theoretically studied. It was found that the mode interference can lead to higher spatial…

Optics · Physics 2007-05-23 N. M. Arslanov , S. A. Moiseev

Optical microscopy is an essential tool in biology and medicine. Imaging thin, yet non-flat objects in a single shot (without relying on more sophisticated sectioning setups) remains challenging as the shallow depth of field that comes with…

Image and Video Processing · Electrical Eng. & Systems 2020-10-14 Adrian Shajkofci , Michael Liebling

We demonstrate the application of Atomic Force Microscopy (AFM) based optical force microscopy to map the optical near-fields with nanometer resolution, limited only by the AFM probe geometry. We map the electric field distributions of…

The field of optical microscopy spans across numerous industries and research domains, ranging from education to healthcare, quality inspection and analysis. Nonetheless, a key limitation often cited by optical microscopists refers to the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Shiraz S Kaderuppan , Jonathan Mar , Andrew Irvine , Anurag Sharma , Muhammad Ramadan Saifuddin , Wai Leong Eugene Wong , Wai Lok Woo

Scanning Electron Microscopy (SEM) is pivotal in revealing intricate micro- and nanoscale features across various research fields. However, obtaining high-resolution SEM images presents challenges, including prolonged scanning durations and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Tom Reclik , Setareh Medghalchi , Philipp Schumacher , Maximilian Wollenweber , Talal Al-Samman , Sandra Korte-Kerzel , Ulrich Kerzel

Understanding and manipulating two-dimensional materials for real-world applications remains challenging due to a lack of effective and high-throughput characterization techniques. Soft X-ray time-of-flight photoemission electron microscopy…

Materials Science · Physics 2025-12-22 Aashwin Mishra , Daniel Ratner , Quynh Nguyen

Second harmonic generation microscopy (SHG) is a powerful imaging modality which has found applications in investigating both biological and synthetic nanostructures. Like all optical microscopy techniques, the resolution of SHG is limited…

Light-field microscopy represents a promising solution for microscopic volumetric imaging, thanks to its capability to encode information on multiple planes in a single acquisition. This is achieved through its peculiar simultaneous capture…

Much more image details can be resolved by improving the system's imaging resolution and enhancing the resolution beyond the system's Rayleigh diffraction limit is generally called super-resolution. By combining the sparse prior property of…

Quantum Physics · Physics 2015-03-20 Wenlin Gong , Shensheng Han

Ptychography is a robust lensless form of microscopy routinely used for applications spanning life and physical sciences. The most common ptychography setup consists in using a detector to record diffraction patterns in the far-field. A…

Imaging below the diffraction limit is always a public interest because of the restricted resolution of conventional imaging systems. To beat the limit, evanescent harmonics decaying in space must participate in the imaging process. Here,…

Optics · Physics 2019-10-02 Tie-Jun Huang , Li-Zheng Yin , Ya Shuang , Jiang-Yu Liu , Yunhua Tan , Pu-Kun Liu
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