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Microtubules (MTs) are dynamic protein filaments essential for intracellular organization and transport, particularly in long-lived cells such as neurons. The plus and minus ends of neuronal MTs switch between growth and shrinking phases,…

Biological Physics · Physics 2025-07-11 Anna C. Nelson , Scott A. McKinley , Melissa M. Rolls , Maria-Veronica Ciocanel

Neurological studies show that injured neurons can regain their functionality with therapeutics such as Chondroitinase ABC (ChABC). These therapeutics promote axon elongation by manipulating the injured neuron and its intercellular space to…

Optimization and Control · Mathematics 2022-09-14 Cenk Demir , Shumon Koga , Miroslav Krstic

In this work we determine a process-level Large Deviation Principle (LDP) for a model of interacting neurons indexed by a lattice $\mathbb{Z}^d$. The neurons are subject to noise, which is modelled as a correlated martingale. The…

Probability · Mathematics 2016-04-05 Olivier Faugeras , James MacLaurin

Gene expression time delays, modelling the complex biological processes of gene transcription and translation, have been shown to play an important role in cellular dynamics. Time delays, motivated by the gene expression process, can also…

Cell Behavior · Quantitative Biology 2022-02-24 Alec Sargood

In this study we consider the Hamiltonian approach for the construction of a map for a system with nonlinear resonant interaction, including phase trapping and phase bunching effects. We derive basic equations for a single resonant…

Multicellular organisms comprise a diverse collection of stable tissues built from different cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue…

Biological Physics · Physics 2022-10-31 Matthew Smart , Anton Zilman

The growth of several biological tissues is known to be controlled in part by local geometrical features, such as the curvature of the tissue interface. This control leads to changes in tissue shape that in turn can affect the tissue's…

Tissues and Organs · Quantitative Biology 2016-12-01 Almie Alias , Pascal R Buenzli

In this paper, we study novel neural network structures to better model long term dependency in sequential data. We propose to use more memory units to keep track of more preceding states in recurrent neural networks (RNNs), which are all…

Neural and Evolutionary Computing · Computer Science 2016-05-03 Rohollah Soltani , Hui Jiang

Collective cell motions underlie structure formation during embryonic development. Tissues exhibit emergent multicellular characteristics such as jamming, rigidity transitions, and glassy dynamics, but there remain questions about how those…

Biological Physics · Physics 2023-12-13 Evan Thomas , Sevan Hopyan

The main objective of this article is to study the order-disorder phase transition and pattern formation for systems with long-range repulsive interactions. The main focus is on the Cahn-Hilliard model with a nonlocal term in the…

Statistical Mechanics · Physics 2011-06-21 Honghu Liu , Taylan Sengul , Shouhong Wang , Pingwen Zhang

Token representations in high-dimensional latent spaces often exhibit redundancy, limiting computational efficiency and reducing structural coherence across model layers. Hierarchical latent space folding introduces a structured…

Computation and Language · Computer Science 2025-08-11 Fenella Harcourt , Naderdel Piero , Gilbert Sutherland , Daphne Holloway , Harriet Bracknell , Julian Ormsby

Capturing the structure of a data-generating process by means of appropriate inductive biases can help in learning models that generalize well and are robust to changes in the input distribution. While methods that harness spatial and…

Reaction-diffusion processes across layered media arise in several scientific domains such as pattern-forming E. coli on agar substrates, epidermal-mesenchymal coupling in development, and symmetry-breaking in cell polarisation. We develop…

Pattern Formation and Solitons · Physics 2020-09-18 Andrew L. Krause , Václav Klika , Jacob Halatek , Paul K. Grant , Thomas E. Woolley , Neil Dalchau , Eamonn A. Gaffney

Planar cell polarity (PCP), the coherent in-plane polarization of a tissue on multicellular length scales, provides directional information that guides a multitude of developmental processes at cellular and tissue levels. While it is…

Biological Physics · Physics 2020-07-01 Shahriar Shadkhoo , Madhav Mani

There is an unmet need for artificial intelligence techniques that can speed up the design of growth strategies for cultured tissues. Cultured tissue is increasingly important for a range of applications such as cultivated meat,…

Biological Physics · Physics 2025-08-04 Allison E. Andrews , Hugh Dickinson , James P. Hague

The explosive growth in sequence length has intensified the demand for effective and efficient long sequence modeling. Benefiting from intrinsic oscillatory membrane dynamics, Resonate-and-Fire (RF) neurons can efficiently extract frequency…

Machine Learning · Computer Science 2025-09-29 Dehao Zhang , Malu Zhang , Shuai Wang , Jingya Wang , Wenjie Wei , Zeyu Ma , Guoqing Wang , Yang Yang , Haizhou Li

Hyperbolic reaction-diffusion equations have recently attracted attention both for their application to a variety of biological and chemical phenomena, and for their distinct features in terms of propagation speed and novel instabilities…

Pattern Formation and Solitons · Physics 2022-08-17 Joshua Ritchie , Andrew L. Krause , Robert A. Van Gorder

While modern deep networks have demonstrated remarkable versatility, their training dynamics remain poorly understood--often driven more by empirical tweaks than architectural insight. This paper investigates how internal structural choices…

Machine Learning · Computer Science 2025-08-26 Saleh Nikooroo , Thomas Engel

Via computer simulations we study evolution dynamics in systems of continuously moving Active Brownian Particles. The obtained results are discussed against those from the passive 2D Ising case. Following sudden quenches of uniform…

Soft Condensed Matter · Physics 2022-12-14 Florian Dittrich , Jiarul Midya , Peter Virnau , Subir K. Das

The kinetics of domain growth and aging in conserved order parameter systems, in the presence of short-range interaction, is widely studied. Due to technical difficulties and lack of resources, regarding computation, the dynamics is still…

Statistical Mechanics · Physics 2023-04-12 Soumik Ghosh , Subir K. Das