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More and more massive parallel codes running on several hundreds of thousands of cores enter the computational science and engineering domain, allowing high-fidelity computations on up to trillions of unknowns for very detailed analyses of…

Performance · Computer Science 2018-07-18 Christoph Ertl , Jérôme Frisch , Ralf-Peter Mundani

Only a small fraction of the data generated in state-of-the-art all-atom multi-microsecond molecular dynamics (MD) simulations is typically analyzed. With femtosecond integration steps, microsecond simulations generate billions of time…

The FITS (Flexible Image Transport System) data format has been the de facto data format for astronomy-related data products since its inception in the late 1970s. While the FITS file format is widely supported, it lacks many of the…

Instrumentation and Methods for Astrophysics · Physics 2015-10-21 D. C. Price , B. R. Barsdell , L. J. Greenhill

Scientific datasets are known for their challenging storage demands and the associated processing pipelines that transform their information. Some of those processing tasks include filtering, cleansing, aggregation, normalization, and data…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-09-27 Lucas C. Villa Real , Maximilien de Bayser

The field of structural bioinformatics has seen significant advances with the use of Molecular Dynamics (MD) simulations of biological systems. The MD methodology has allowed to explain and discover molecular mechanisms in a wide range of…

In High Energy Physics (HEP), experimentalists generate large volumes of data that, when analyzed, helps us better understand the fundamental particles and their interactions. This data is often captured in many files of small size,…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-04 Sunwoo Lee , Kai-yuan Hou , Kewei Wang , Saba Sehrish , Marc Paterno , James Kowalkowski , Quincey Koziol , Robert Ross , Ankit Agrawal , Alok Choudhary , Wei-keng Liao

Nowadays simulations can produce petabytes of data to be stored in parallel filesystems or large-scale databases. This data is accessed over the course of decades often by thousands of analysts and scientists. However, storing these volumes…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-02-11 Salvatore Di Girolamo , Pirmin Schmid , Thomas Schulthess , Torsten Hoefler

Scientific data is often stored in files because of the simplicity they provide in managing, transferring, and sharing data. These files are typically structured in a specific arrangement and contain metadata to understand the structure the…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-02-07 Sriniket Ambatipudi , Suren Byna

In this work, a new algorithm based on the application of higher-order dynamic mode decomposition (HODMD) is proposed for feature selection and variables clustering in reacting flow simulations. The hierarchical HODMD (h-HODMD) performs a…

Molecular dynamics (MD) simulations present a data-mining challenge, given that they can generate a considerable amount of data but often rely on limited or biased human interpretation to examine their information content. By not asking the…

Materials Science · Physics 2025-07-31 Fabrice Roncoroni , Ana Sanz-Matias , Siddharth Sundararaman , David Prendergast

The RMPCDMD software package performs hybrid Molecular Dynamics simulations, coupling Multiparticle Collision Dynamics to model the solvent and Molecular Dynamics to model suspended colloids, including hydrodynamics, thermal fluctuations,…

Computational Physics · Physics 2017-01-13 Pierre de Buyl , Mu-Jie Huang , Laurens Deprez

Molecular dynamics (MD) has long been the de facto choice for simulating complex atomistic systems from first principles. Recently deep learning models become a popular way to accelerate MD. Notwithstanding, existing models depend on…

Computational Engineering, Finance, and Science · Computer Science 2023-01-10 Fang Wu , Stan Z. Li

Heterogeneous multiscale methods (HMM) combine molecular accuracy of particle-based simulations with the computational efficiency of continuum descriptions to model flow in soft matter liquids. In these schemes, molecular simulations…

The integration of molecular and natural language representations has emerged as a focal point in molecular science, with recent advancements in Language Models (LMs) demonstrating significant potential for comprehensive modeling of both…

Biomolecules · Quantitative Biology 2025-03-19 Qizhi Pei , Rui Yan , Kaiyuan Gao , Jinhua Zhu , Lijun Wu

Systems composed of soft matter (e.g., liquids, polymers, foams, gels, colloids, and most biological materials) are ubiquitous in science and engineering, but molecular simulations of such systems pose particular computational challenges,…

ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales,…

Computational Physics · Physics 2016-01-11 Endre Somogyi , Andrew Abi Mansour , Peter J. Ortoleva

Computer simulation is an important tool for scientific progress, especially when lab experiments are either extremely costly and difficult or lack the required resolution. However, all of the simulation methods come with limitations. In…

Fluid Dynamics · Physics 2023-08-04 Edward R. Smith , Panagiotis E. Theodorakis

The increasingly collaborative, globalized nature of scientific research combined with the need to share data and the explosion in data volumes present an urgent need for a scientific data management system (SDMS). An SDMS presents a…

Databases · Computer Science 2020-04-09 Dale Stansberry , Suhas Somnath , Jessica Breet , Gregory Shutt , Mallikarjun Shankar

Metal-organic frameworks (MOFs) are porous materials composed of metal ions and organic linkers. Due to their chemical diversity, MOFs can support a broad range of applications in chemical separations. However, the vast amount of structural…

Photon-HDF5 is an open-source and open file format for storing photon-counting data from single molecule microscopy experiments, introduced to simplify data exchange and increase the reproducibility of data analysis. Part of the Photon-HDF5…

Quantitative Methods · Quantitative Biology 2022-03-22 Donald Ferschweiler , Maya Segal , Shimon Weiss , Xavier Michalet
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