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Since the advent of modern bioinformatics, the challenging, multifaceted problem of reconstructing phylogenetic history from biological sequences has hatched perennial statistical and algorithmic innovation. Studies of the phylogenetic…

Data Structures and Algorithms · Computer Science 2024-03-05 Matthew Andres Moreno , Santiago Rodriguez Papa , Emily Dolson

The Dollo model for reconstructing evolutionary trees from binary characters has been proposed as a generalization of the infinite sites model, also known as the Perfect Phylogeny. In particular, the Dollo model is considered more realistic…

Data Structures and Algorithms · Computer Science 2025-06-17 Paola Bonizzoni , Gianluca Della Vedova , Mauricio Soto Gomez , Gabriella Trucco

Phylogenetic trees and networks are leaf-labelled graphs used to model evolution. Display graphs are created by identifying common leaf labels in two or more phylogenetic trees or networks. The treewidth of such graphs is bounded as a…

Data Structures and Algorithms · Computer Science 2018-09-05 Remie Janssen , Mark Jones , Steven Kelk , Georgios Stamoulis , Taoyang Wu

A phylogenetic tree is a way to organize a finite set of species, individuals or other sources of related data. The species for which we have existing DNA data make up the set of leaves of the tree. The balanced minimal evolution method of…

Combinatorics · Mathematics 2016-08-05 Stefan Forcey , Logan Keefe , William Sands

Phylogenetic trees represent certain species and their likely ancestors. In such a tree, present-day species are leaves and an edge from u to v indicates that u is an ancestor of v. Weights on these edges indicate the phylogenetic distance.…

Populations and Evolution · Quantitative Biology 2025-10-08 Jannik Schestag

In evolutionary biology, phylogenetic trees are commonly inferred from a set of characters (partitions) of a collection of biological entities (e.g., species or individuals in a population). Such characters naturally arise from molecular…

Populations and Evolution · Quantitative Biology 2023-11-17 Katharina T. Huber , Simone Linz , Vincent Moulton , Charles Semple

The current picture of bacterial evolution is based largely on studies of 16S rRNA. However, this is just one gene. It is known that horizontal gene transfer can occur between bacterial species, although the frequency and implications of…

Populations and Evolution · Quantitative Biology 2007-05-23 Bin Tang , Philippe Boisvert , Paul G. Higgs

$\textbf{Motivation:}$ Hierarchical data structures are prevalent across several fields of research, as they represent an organised and efficient approach to study complex interconnected systems. Their significance is particularly evident…

Mathematical Software · Computer Science 2024-12-06 Giulio Benedetti , Ely Seraidarian , Theotime Pralas , Akewak Jeba , Tuomas Borman , Leo Lahti

Phylogenetic networks provide a way to describe and visualize evolutionary histories that have undergone so-called reticulate evolutionary events such as recombination, hybridization or horizontal gene transfer. The level k of a network…

Populations and Evolution · Quantitative Biology 2008-07-21 Leo van Iersel , Steven Kelk , Matthias Mnich

Phylogenetic networks are increasingly used in evolutionary biology to represent the history of species that have undergone reticulate events such as horizontal gene transfer, hybrid speciation and recombination. One of the most fundamental…

Populations and Evolution · Quantitative Biology 2016-10-07 Philippe Gambette , Leo van Iersel , Steven Kelk , Fabio Pardi , Celine Scornavacca

Phylogenetics is a widely used concept in evolutionary biology. It is the reconstruction of evolutionary history by building trees that represent branching patterns and sequences. These trees represent shared history, and it is our…

Astrophysics of Galaxies · Physics 2018-08-22 P. Jofre , P. Das

The presence of reticulate evolutionary events in phylogenies turn phylogenetic trees into phylogenetic networks. These events imply in particular that there may exist multiple evolutionary paths from a non-extant species to an extant one,…

Populations and Evolution · Quantitative Biology 2008-03-21 Gabriel Cardona , Merce Llabres , Francesc Rossello , Gabriel Valiente

Phylogenetic networks are rooted, labelled directed acyclic graphs which are commonly used to represent reticulate evolution. There is a close relationship between phylogenetic networks and multi-labelled trees (MUL-trees). Indeed, any…

Populations and Evolution · Quantitative Biology 2015-06-16 Katharina T. Huber , Vincent Moulton , Mike Steel , Taoyang Wu

In the global challenge of understanding and characterizing biodiversity, short species-specific genomic sequences known as DNA barcodes play a critical role, enabling fine-grained comparisons among organisms within the same kingdom of…

Decision trees have been widely used as classifiers in many machine learning applications thanks to their lightweight and interpretable decision process. This paper introduces Tree in Tree decision graph (TnT), a framework that extends the…

Machine Learning · Computer Science 2021-11-01 Bingzhao Zhu , Mahsa Shoaran

Phytoplankton, a crucial component of aquatic ecosystems, requires efficient monitoring to understand marine ecological processes and environmental conditions. Traditional phytoplankton monitoring methods, relying on non-in situ…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Yang Yu , Qingxuan Lv , Yuezun Li , Zhiqiang Wei , Junyu Dong

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

Populations and Evolution · Quantitative Biology 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

t-SNE and hierarchical clustering are popular methods of exploratory data analysis, particularly in biology. Building on recent advances in speeding up t-SNE and obtaining finer-grained structure, we combine the two to create tree-SNE, a…

Machine Learning · Computer Science 2020-02-14 Isaac Robinson , Emma Pierce-Hoffman

Rearrangement operations transform a phylogenetic tree into another one and hence induce a metric on the space of phylogenetic trees. Popular operations for unrooted phylogenetic trees are NNI (nearest neighbour interchange), SPR (subtree…

Combinatorics · Mathematics 2019-12-24 Remie Janssen , Jonathan Klawitter

Selecting compact and informative gene subsets from single-cell transcriptomic data is essential for biomarker discovery, improving interpretability, and cost-effective profiling. However, most existing feature selection approaches either…

Machine Learning · Computer Science 2025-12-22 Daphné Chopard , Jorge da Silva Gonçalves , Irene Cannistraci , Thomas M. Sutter , Julia E. Vogt