Related papers: Biological effects and equivalent doses in radioth…
In traditional dose-finding studies, dose-limiting toxicity (DLT) is determined within a fixed time observation window where DLT is often defined as a binary outcome. In the setting of oncology dose-finding trials, often patients in…
Radiotherapy is an integral part of treatment for many patients with breast cancer. However, side effects can occur, Example fibrosis or erythema. If patients at higher risks of radiation induced side effects could be identified before…
Treatment-related lymphopenia is a frequent and clinically significant consequence of cancer therapy that can compromise immune-mediated tumor control and worsen patient outcomes. Despite its importance, no mechanistic framework exists to…
Comparative diagnostic in brain tumor evaluation makes possible to use the available information of a medical center to compare similar cases when a new patient is evaluated. By leveraging Artificial Intelligence models, the proposed system…
Clinical applications of FLASH radiotherapy require formulas to describe how the FLASH radiation features and other related factors determine the FLASH effect. Mathematical analysis of the models can connect the theoretical hypotheses with…
In this work, we have investigated the sensitivity of the effectiveness (TCP) of molecular radiotherapy (MRT) treatment to uncertainties of the dose rate curves that may appear when reconstructing those curves. We generated different dose…
Radiation therapy is an effective and widely accepted form of treatment for many types of cancer that requires extensive computerized planning. Unfortunately, current treatment planning systems have limited or no visual aid that combines…
Achieving effective synergy between radiotherapy and immunotherapy is critical for optimizing tumor control and treatment outcomes. To explore the underlying mechanisms of this synergy, we have investigated a novel treatment approach known…
Objective: This study aims to investigate the influence of organ architecture (specifically the distinction between serial and parallel tissue) on the protective FLASH effect when organs are irradiated with inhomogeneous dose distributions.…
In carbon-ion radiotherapy, single-beam delivery each day in alternate directions has been commonly practiced for operational efficiency, taking advantage of the Bragg peak and the relative biological effectiveness (RBE) for uniform dose…
Background: Gliomas are the most common brain tumors, which vary from low to high-grade. Despite the improvements in imaging techniques in the last decade, all parts of the tumor are not visible in these images, due to having a threshold of…
Causal inference problems often involve continuous treatments, such as dose, duration, or frequency. However, identifying and estimating standard dose-response estimands requires that everyone has some chance of receiving any level of the…
It has been shown recently that changing the fluidic properties of a drug can improve its efficacy in ablating solid tumors. We develop a modeling framework for tumor ablation, and present the simplest possible model for drug diffusion in a…
The linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting…
The expression of survival factors for radiation damaged cells is based on probabilistic assumptions and experimentally fitted for each tumor, radiation and conditions. Here we show how the simplest of these radiobiological models can be…
Diffusing alpha-emitters Radiation Therapy ("Alpha DaRT") is a new treatment modality focusing on the use of alpha particles against solid tumors. The introduction of Alpha DaRT in clinical settings calls for the development of detailed…
In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these treatments often lead to an initial reduction in the abundance…
There is evidence that the population of cells that experience fluctuating oxygen levels are more radioresistant than chronically hypoxic ones and hence, this population may determine radiotherapy (RT) response, in particular for…
The efficacy of drug treatments depends on how tightly small molecules bind to their target proteins. The rapid and accurate quantification of the strength of these interactions (as measured by binding affinity) is a grand challenge of…
We present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying…