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The containment of epidemic spreading is a major challenge in science. Vaccination, whenever available, is the best way to prevent the spreading, because it eventually immunizes individuals. However, vaccines are not perfect, and total…

Many epidemic models approximate social contact behavior by assuming random mixing within mixing groups (e.g., homes, schools and workplaces). The effect of more realistic social network structure on estimates of epidemic parameters is an…

Methodology · Statistics 2012-08-27 Gail E. Potter , Mark S. Handcock , Ira M. Longini, , M. Elizabeth Halloran

On 11 June the World Health Organization officially raised the phase of pandemic alert (with regard to the new H1N1 influenza strain) to level 6. We use a global structured metapopulation model integrating mobility and transportation data…

With significant population fractions in many societies who refuse vaccines, it is important to reconsider how vaccination is incorporated into compartmental epidemiology models. It is still most common to apply the vaccination rate to the…

Populations and Evolution · Quantitative Biology 2026-03-09 Glenn Ledder

Vaccination is crucial for the control of epidemics. Yet it is a social dilemma since non-vaccinators can benefit from the herd immunity created by the vaccinators. Thus the optimum vaccination level is not reached via voluntary vaccination…

Populations and Evolution · Quantitative Biology 2019-02-06 Yuting Wei , Yaosen Lin , Bin Wu

We study how a fraction of a population should be vaccinated to most efficiently top epidemics. We argue that only local information (about the neighborhood of specific vertices) is usable in practice, and hence we consider only local…

Populations and Evolution · Quantitative Biology 2007-05-23 Petter Holme

Optimal strategies for epidemic containment are focused on dismantling the contact network through effective immunization with minimal costs. However, network fragmentation is seldom accessible in practice and may present extreme side…

Physics and Society · Physics 2020-02-26 Guilherme S. Costa , Silvio C. Ferreira

H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with…

Populations and Evolution · Quantitative Biology 2012-04-30 Keyao Pan , Krystina C. Subieta , Michael W. Deem

In this study, we present an immuno-epidemic model to understand mitigation options during an epidemic break. The model incorporates comorbidity and multiple-vaccine doses through a system of coupled integro-differential equations to…

Populations and Evolution · Quantitative Biology 2025-05-28 Samiran Ghosh , Malay Banerjee , Amit K Chattopadhyay

Infectious diseases cause more than 13 million deaths a year, worldwide. Globalization, urbanization, climate change, and ecological pressures have significantly increased the risk of a global pandemic. The ongoing COVID-19 pandemic-the…

Computers and Society · Computer Science 2021-04-23 Elizabeth Bradley , Madhav Marathe , Melanie Moses , William D Gropp , Daniel Lopresti

Seasonal influenza infects between 10 and 50 million people in the United States every year, overburdening hospitals during weeks of peak incidence. Named by the CDC as an important tool to fight the damaging effects of these epidemics,…

Applications · Statistics 2020-05-19 Thomas McAndrew , Nicholas G. Reich

Vaccination is an important measure available for preventing or reducing the spread of infectious diseases. In this paper, an epidemic model including susceptible, infected, and imperfectly vaccinated compartments is studied on…

Physics and Society · Physics 2015-06-15 Xiao-Long Peng , Xin-Jian Xu , Xinchu Fu , Tao Zhou

This article reviews quantitative methods to estimate the basic reproduction number of pandemic influenza, a key threshold quantity to help determine the intensity of interventions required to control the disease. Although it is difficult…

Populations and Evolution · Quantitative Biology 2009-11-13 Gerardo Chowell , Hiroshi Nishiura

In this work we analyze the evolution of voluntary vaccination in networked populations by entangling the spreading dynamics of an influenza-like disease with an evolutionary framework taking place at the end of each influenza season so…

Physics and Society · Physics 2013-09-11 Alessio Cardillo , Catalina Reyes-Suárez , Fernando Naranjo , Jesús Gómez-Gardeñes

Background: Despite the consensus that vaccines play an important role in combating the global spread of infectious diseases, vaccine inequity is still rampant with deep-seated mentality of self-priority. This study aims to evaluate the…

Populations and Evolution · Quantitative Biology 2023-10-16 Zhenyu Han , Qianyue Hao , Qiwei He , Katherine Budeski , Depeng Jin , Fengli Xu , Kun Tang

Influenza epidemics result in a public health and economic burden around the globe. Traditional surveillance techniques, which rely on doctor visits, provide data with a delay of 1-2 weeks. A means of obtaining real-time data and…

Populations and Evolution · Quantitative Biology 2019-04-11 Wendy K. Caldwell , Geoffrey Fairchild , Sara Y. Del Valle

We propose a new method to immunize populations or computer networks against epidemics which is more efficient than any method considered before. The novelty of our method resides in the way of determining the immunization targets. First we…

Physics and Society · Physics 2015-06-03 Christian M. Schneider , Tamara Mihaljev , Hans J. Herrmann

Containing an epidemic at its origin is the most desirable mitigation. Epidemics have often originated in rural areas, with rural communities among the first affected. Disease dynamics in rural regions have received limited attention, and…

This work consists of an epidemic model with vaccination coupled with an opinion dynamics. Our objective was to study how disease risk perception can influence opinions about vaccination and therefore the spreading of the disease.…

Physics and Society · Physics 2019-11-20 Marcelo A. Pires , André L. Oestereich , Nuno Crokidakis

The potential waning of the vaccination immunity to COVID-19 could pose threats to public health, as it is tenable that the timing of such waning would synchronize with the near-complete restoration of normalcy. Should also testing be…

Populations and Evolution · Quantitative Biology 2022-01-28 Agnieszka Truszkowska , Lorenzo Zino , Sachit Butail , Emanuele Caroppo , Zhong-Ping Jiang , Alessandro Rizzo , Maurizio Porfiri