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Decoding the genome confers the capability to predict characteristics of the organism(phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly…

Genomics · Quantitative Biology 2021-01-18 Timothy G. Raben , Louis Lello , Erik Widen , Stephen D. H. Hsu

Genetically identical cells in the same population can take on phenotypically variable states, leading to differentiated responses to external signals, such as nutrients and drug-induced stress. Many models and experiments have focused on a…

Molecular Networks · Quantitative Biology 2015-04-28 Thierry Mora , Aleksandra M. Walczak

Quantifying human group dynamics represents a unique challenge. Unlike animals and other biological systems, humans form groups in both real (offline) and virtual (online) spaces -- from potentially dangerous street gangs populated mostly…

Physics and Society · Physics 2015-05-13 Neil F. Johnson , Chen Xu , Zhenyuan Zhao , Nicolas Ducheneaut , Nicholas Yee , George Tita , Pak Ming Hui

Studies using massive, passively data collected from communication technologies have revealed many ubiquitous aspects of social networks, helping us understand and model social media, information diffusion, and organizational dynamics. More…

Physics and Society · Physics 2015-02-04 Jameson L. Toole , Carlos Herrera-Yague , Christian M. Schneider , Marta C. Gonzalez

One of interesting phenomena due to topological heterogeneities in complex networks is the friendship paradox: Your friends have on average more friends than you do. Recently, this paradox has been generalized for arbitrary node attributes,…

Physics and Society · Physics 2014-08-26 Hang-Hyun Jo , Young-Ho Eom

Two complementary mechanisms are thought to shape social groups: homophily between agents and structural balance in connected triads. Here we consider $N$ fully connected agents, where each agent has $G$ underlying attributes, and the…

Physics and Society · Physics 2020-08-19 Piotr J. Górski , Klavdiya Bochenina , Janusz A. Hołyst , Raissa M. D'Souza

We study genetic networks that produce many species of non-coding RNA molecules that are present at a moderate density, as typically exists in the cell. The associations of the many species of these RNA are modeled physically, taking into…

Genomics · Quantitative Biology 2014-09-08 J. M. Deutsch

We consider a dynamic network of individuals that may hold one of two different opinions in a two-party society. As a dynamical model, agents can endlessly create and delete links to satisfy a preferred degree, and the network is shaped by…

Statistical Mechanics · Physics 2021-10-26 Xiang Li , Mauro Mobilia , Alastair M. Rucklidge , R. K. P. Zia

Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…

Populations and Evolution · Quantitative Biology 2018-04-23 Richard A. Neher , Aleksandra M. Walczak

Evolutionary dynamics can be studied in well-mixed or structured populations. Population structure typically arises from the heterogeneous distribution of individuals in physical space or on social networks. Here we introduce a new type of…

Populations and Evolution · Quantitative Biology 2009-06-04 Tibor Antal , Hisashi Ohtsuki , John Wakeley , Peter D. Taylor , Martin A. Nowak

Ecosystems are formed by networks of species and their interactions. Traditional models of such interactions assume a constant interaction strength between a given pair of species. However, there is often significant trait variation among…

Populations and Evolution · Quantitative Biology 2022-05-03 Zachary Jackson , BingKan Xue

Evolutionary graph theory is a well established framework for modelling the evolution of social behaviours in structured populations. An emerging consensus in this field is that graphs that exhibit heterogeneity in the number of connections…

Populations and Evolution · Quantitative Biology 2018-11-20 Wes Maciejewski , Feng Fu , Christoph Hauert

Spatial environmental variation can either amplify or suppress the fixation of beneficial mutants in structured populations, yet the interplay of ecological factors and spatial structure in determining which outcome occurs remains…

Populations and Evolution · Quantitative Biology 2026-05-07 Hossein Nemati , Kamran Kaveh , Jakub Svoboda , Mohammad Reza Ejtehadi , Krishnendu Chatterjee

Mechanisms leading to speciation are a major focus in evolutionary biology. In this paper, we present and study a stochastic model of population where individuals, with type a or A, are equivalent from ecological, demographical and spatial…

Populations and Evolution · Quantitative Biology 2017-04-20 Camille Coron , Manon Costa , Hélène Leman , Charline Smadi

The relationship between sequences and secondary structures or shapes in RNA exhibits robust statistical properties summarized by three notions: (1) the notion of a typical shape (that among all sequences of fixed length certain shapes are…

Biological Physics · Physics 2009-10-31 Peter Schuster , Walter Fontana

Genetic association data from national biobanks and large-scale association studies have provided new prospects for understanding the genetic evolution of complex traits and diseases in humans. In turn, genomes from ancient human…

Populations and Evolution · Quantitative Biology 2021-08-06 Evan K. Irving-Pease , Rasa Muktupavela , Michael Dannemann , Fernando Racimo

The assembly of ecological communities from a pool of species is central to ecology, but the effect of this process on properties of community interaction networks is still largely unknown. Here, we use a systematic analytical framework to…

Populations and Evolution · Quantitative Biology 2016-07-19 Guy Bunin

"Rich-get-richer" and "homophily" are two important phenomena in evolving social networks. "Rich-get-richer" means people with higher followings are more likely to attract new fans, and "homophily" means people prefer to bond with others of…

Methodology · Statistics 2022-04-26 Hanyang Tian , Bo Zhang , Ruixue Jiang

The personal network of relationships is structured in circles of friendships, that go from the most intense relationships to the least intense ones. While this is a well established result, little is known about the stability of those…

Physics and Society · Physics 2023-09-04 Diego Escribano , Francisco J. Lapuente , José A. Cuesta , Robin I. M. Dunbar , Angel Sánchez

In classical evolutionary theory, genetic variation provides the source of heritable phenotypic variation on which natural selection acts. Against this classical view, several theories have emphasized that developmental variability and…

Populations and Evolution · Quantitative Biology 2011-11-08 Steven A. Frank
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