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Large scale databases are available that contain homologous gene families constructed from hundreds of complete genome sequences from across the three domains of Life. Here we discuss approches of increasing complexity aimed at extracting…
Understanding the dynamics of genome rearrangements is a major issue of phylogenetics. Phylogenetics is the study of species evolution. A major goal of the field is to establish evolutionary relationships within groups of species, in order…
The advent of modern technology, permitting the measurement of thousands of characteristics simultaneously, has given rise to floods of data characterized by many large or even huge datasets. This new paradigm presents extraordinary…
In recent years, Whole Genome Sequencing (WGS) evolved from a futuristic-sounding research project to an increasingly affordable technology for determining complete genome sequences of complex organisms, including humans. This prompts a…
Astronomy produces extremely large data sets from ground-based telescopes, space missions, and simulation. The volume and complexity of these rich data sets require new approaches and advanced tools to understand the information contained…
Biology is at the precipice of a new era where AI accelerates and amplifies the ability to study how cells operate, organize, and work as systems, revealing why disease happens and how to correct it. Organizations globally are prioritizing…
The inference of new information on the relatedness of species by phylogenetic trees based on DNA data is one of the main challenges of modern biology. But despite all technological advances, DNA sequencing is still a time-consuming and…
Astronomy has entered the big data era and Machine Learning based methods have found widespread use in a large variety of astronomical applications. This is demonstrated by the recent huge increase in the number of publications making use…
Advances in information technology and its widespread growth in several areas of business, engineering, medical and scientific studies are resulting in information/data explosion. Knowledge discovery and decision making from such rapidly…
Genetic studies of human traits have revolutionized our understanding of the variation between individuals, and opened the door for numerous breakthroughs in biology, medicine and other scientific fields. And yet, the ultimate promise of…
Decoding the genome confers the capability to predict characteristics of the organism(phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly…
Molecular phylogeny has focused mainly on improving models for the reconstruction of gene trees based on sequence alignments. Yet, most phylogeneticists seek to reveal the history of species. Although the histories of genes and species are…
The recent interest in Big Data has generated a broad range of new academic, corporate, and policy practices along with an evolving debate amongst its proponents, detractors, and skeptics. While the practices draw on a common set of tools,…
With the rapid growth of modern technology, many large-scale biomedical studies have been/are being/will be conducted to collect massive datasets with large volumes of multi-modality imaging, genetic, neurocognitive, and clinical…
As our capacity to study ever-expanding domains of our science has increased (including the time domain, non-electromagnetic phenomena, magnetized plasmas, and numerous sky surveys in multiple wavebands with broad spatial coverage and…
The emergence of "Big Data" as a dominant technology meme challenges Geography's technical underpinnings, found in GIS, while engaging the discipline in a conversation about the meme's impact on society. This allows scholars to engage…
As sequencing technologies become more affordable and genomic databases expand continuously, the reuse of publicly available sequencing data emerges as a powerful strategy for studying microbial pathogens. Indeed, raw sequencing reads…
Astronomy is increasingly encountering two fundamental truths: (1) The field is faced with the task of extracting useful information from extremely large, complex, and high dimensional datasets; (2) The techniques of astroinformatics and…
Humanity has wondered whether we are alone for millennia. The discovery of life elsewhere in the Universe, particularly intelligent life, would have profound effects, comparable to those of recognizing that the Earth is not the center of…
Many aspects of the evolution of stars, and in particular the evolution of binary stars, remain beyond our ability to model them in detail. Instead, we rely on observations to guide our often phenomenological models and pin down uncertain…