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We add a set of convex constraints to the lasso to produce sparse interaction models that honor the hierarchy restriction that an interaction only be included in a model if one or both variables are marginally important. We give a precise…

Methodology · Statistics 2013-06-20 Jacob Bien , Jonathan Taylor , Robert Tibshirani

We consider the testing of all pairwise interactions in a two-class problem with many features. We devise a hierarchical testing framework that considers an interaction only when one or more of its constituent features has a nonzero main…

Methodology · Statistics 2015-06-03 Jacob Bien , Noah Simon , Robert Tibshirani

While including pairwise interactions in a regression model can better approximate response surface, fitting such an interaction model is a well-known difficult problem. In particular, analyzing contemporary high-dimensional datasets often…

Methodology · Statistics 2024-01-17 Hai Lu , Guo Yu

Interacting particle systems play a key role in science and engineering. Access to the governing particle interaction law is fundamental for a complete understanding of such systems. However, the inherent system complexity keeps the…

Machine Learning · Computer Science 2022-10-25 Zhichao Han , David S. Kammer , Olga Fink

We propose a procedure for sparse regression with pairwise interactions, by generalizing the Univariate Guided Sparse Regression (UniLasso) methodology. A central contribution is our introduction of a concept of univariate (or marginal)…

Methodology · Statistics 2026-01-05 Aymen Echarghaoui , Robert Tibshirani

This paper studies estimation and inference of heterogeneous peer effects featuring group fixed effects and slope heterogeneity under latent structure. We adapt the Classifier-Lasso algorithm to consistently discover latent structures and…

Methodology · Statistics 2026-02-09 Zhongjian Lin , Zhentao Shi , Yapeng Zheng

We introduce a pliable lasso method for estimation of interaction effects in the Cox proportional hazards model framework. The pliable lasso is a linear model that includes interactions between covariates X and a set of modifying variables…

Applications · Statistics 2018-07-19 Wenfei Du , Rob Tibshirani

An important problem in the field of bioinformatics is to identify interactive effects among profiled variables for outcome prediction. In this paper, a logistic regression model with pairwise interactions among a set of binary covariates…

Artificial Intelligence · Computer Science 2016-12-30 Easton Li Xu , Xiaoning Qian , Tie Liu , Shuguang Cui

In many learning settings, it is beneficial to augment the main features with pairwise interactions. Such interaction models can be often enhanced by performing variable selection under the so-called strong hierarchy constraint: an…

Machine Learning · Statistics 2020-07-15 Hussein Hazimeh , Rahul Mazumder

Models that rely solely on pairwise relationships often fail to capture the complete statistical structure of the complex multivariate data found in diverse domains, such as socio-economic, ecological, or biomedical systems. Non-trivial…

Machine Learning · Statistics 2023-11-08 Zhaolu Liu , Robert L. Peach , Pedro A. M. Mediano , Mauricio Barahona

We consider the problem of learning the structure of a pairwise graphical model over continuous and discrete variables. We present a new pairwise model for graphical models with both continuous and discrete variables that is amenable to…

Machine Learning · Statistics 2013-07-05 Jason D. Lee , Trevor J. Hastie

Estimating global pairwise interaction effects, i.e., the difference between the joint effect and the sum of marginal effects of two input features, with uncertainty properly quantified, is centrally important in science applications. We…

Machine Learning · Computer Science 2020-07-14 Tianyu Cui , Pekka Marttinen , Samuel Kaski

We describe a regularized regression model for the selection of gene-environment (GxE) interactions. The model focuses on a single environmental exposure and induces a main-effect-before-interaction hierarchical structure. We propose an…

Methodology · Statistics 2022-02-08 Natalia Zemlianskaia , W. James Gauderman , Juan Pablo Lewinger

Interacting systems are ubiquitous in nature and engineering, ranging from particle dynamics in physics to functionally connected brain regions. These interacting systems can be modeled by graphs where edges correspond to the interactions…

Machine Learning · Computer Science 2024-01-25 Zhichao Han , Olga Fink , David S. Kammer

Discovering interaction effects on a response of interest is a fundamental problem faced in biology, medicine, economics, and many other scientific disciplines. In theory, Bayesian methods for discovering pairwise interactions enjoy many…

Computation · Statistics 2022-11-15 Raj Agrawal , Jonathan H. Huggins , Brian Trippe , Tamara Broderick

We study the problem of high-dimensional regression when there may be interacting variables. Approaches using sparsity-inducing penalty functions such as the Lasso can be useful for producing interpretable models. However, when the number…

Methodology · Statistics 2016-12-30 Rajen D. Shah

Sparse regression problems, where the goal is to identify a small set of relevant predictors, often require modeling not only main effects but also meaningful interactions through other variables. While the pliable lasso has emerged as a…

Methodology · Statistics 2025-09-10 The Tien Mai

Interaction within small groups can often be represented as a sequence of events, where each event involves a sender and a recipient. Recent methods for modeling network data in continuous time model the rate at which individuals interact…

Methodology · Statistics 2012-08-01 Christopher DuBois , Carter T. Butts , Daniel McFarland , Padhraic Smyth

Logistic Regression (LR) is a widely used statistical method in empirical binary classification studies. However, real-life scenarios oftentimes share complexities that prevent from the use of the as-is LR model, and instead highlight the…

Machine Learning · Computer Science 2024-05-15 Michela C. Massi , Nicola R. Franco , Francesca Ieva , Andrea Manzoni , Anna Maria Paganoni , Paolo Zunino

Pairwise models like the Ising model or the generalized Potts model have found many successful applications in fields like physics, biology, and economics. Closely connected is the problem of inverse statistical mechanics, where the goal is…

Disordered Systems and Neural Networks · Physics 2022-01-12 Christoph Feinauer , Carlo Lucibello
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