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Transcription of the genetic message encoded chemically in the sequence of the DNA template is carried out by a molecular machine called RNA polymerase (RNAP). Backward or forward slippage of the nascent RNA with respect to the DNA template…

Biological Physics · Physics 2017-04-18 Soumendu Ghosh , Shubhadeep Patra , Debashish Chowdhury

Polymerization of RNA from a template DNA is carried out by a molecular machine called RNA polymerase (RNAP). It also uses the template as a track on which it moves as a motor utilizing chemical energy input. The time it spends at each…

Statistical Mechanics · Physics 2015-05-13 Tripti Tripathi , Gunter M. Schütz , Debashish Chowdhury

Diffusion-based text-to-speech (TTS) systems have made remarkable progress in zero-shot speech synthesis, yet optimizing all components for perceptual metrics remains challenging. Prior work with DMOSpeech demonstrated direct metric…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-22 Yinghao Aaron Li , Xilin Jiang , Fei Tao , Cheng Niu , Kaifeng Xu , Juntong Song , Nima Mesgarani

We present the Latent Timbre Synthesis (LTS), a new audio synthesis method using Deep Learning. The synthesis method allows composers and sound designers to interpolate and extrapolate between the timbre of multiple sounds using the latent…

Audio and Speech Processing · Electrical Eng. & Systems 2020-11-03 K. Tatar , D. Bisig , P. Pasquier

In time-critical systems, such as air traffic control systems, it is crucial to design control policies that are robust to timing uncertainty. Recently, the notion of Asynchronous Temporal Robustness (ATR) was proposed to capture the…

Systems and Control · Electrical Eng. & Systems 2023-07-25 Xinyi Yu , Xiang Yin , Lars Lindemann

Ensuring the correctness of critical real-time systems, involving concurrent behaviours and timing requirements, is crucial. Timed automata extend finite-state automata with clocks, compared in guards and invariants with integer constants.…

Logic in Computer Science · Computer Science 2026-05-06 Étienne André , Didier Lime , Olivier H. Roux

Neural network based end-to-end text to speech (TTS) has significantly improved the quality of synthesized speech. Prominent methods (e.g., Tacotron 2) usually first generate mel-spectrogram from text, and then synthesize speech from the…

Computation and Language · Computer Science 2019-11-21 Yi Ren , Yangjun Ruan , Xu Tan , Tao Qin , Sheng Zhao , Zhou Zhao , Tie-Yan Liu

Accented text-to-speech (TTS) synthesis seeks to generate speech with an accent (L2) as a variant of the standard version (L1). Accented TTS synthesis is challenging as L2 is different from L1 in both in terms of phonetic rendering and…

Sound · Computer Science 2022-09-23 Rui Liu , Berrak Sisman , Guanglai Gao , Haizhou Li

Syntax-guided synthesis is a paradigm in program synthesis in which the search space of candidate solutions is constrained by a syntactic template in the form of a grammar. These syntactic constraints serve two purposes: constraining the…

Software Engineering · Computer Science 2023-06-06 Yixuan Li , Federico Mora , Elizabeth Polgreen , Sanjit A. Seshia

In recent years, speech diffusion models have advanced rapidly. Alongside the widely used U-Net architecture, transformer-based models such as the Diffusion Transformer (DiT) have also gained attention. However, current DiT speech models…

Temporal distribution shift (TDS) erodes the long-term accuracy of recommender systems, yet industrial practice still relies on periodic incremental training, which struggles to capture both stable and transient patterns. Existing…

Machine Learning · Computer Science 2025-11-27 Yuxuan Zhu , Cong Fu , Yabo Ni , Anxiang Zeng , Yuan Fang

The usage of medical image data for the training of large-scale machine learning approaches is particularly challenging due to its scarce availability and the costly generation of data annotations, typically requiring the engagement of…

Computer Vision and Pattern Recognition · Computer Science 2024-06-26 Joshua Niemeijer , Jan Ehrhardt , Hristina Uzunova , Heinz Handels

Discrete diffusion models have emerged as a powerful paradigm for generative modeling on sequence data; however, the information-theoretic principles governing their reverse processes remain significantly less understood than those of their…

Machine Learning · Computer Science 2026-02-10 Alberto Foresti , Mustapha Bounoua , Giulio Franzese , Luca Ambrogioni , Pietro Michiardi

This paper describes Mixer-TTS, a non-autoregressive model for mel-spectrogram generation. The model is based on the MLP-Mixer architecture adapted for speech synthesis. The basic Mixer-TTS contains pitch and duration predictors, with the…

Audio and Speech Processing · Electrical Eng. & Systems 2021-10-25 Oktai Tatanov , Stanislav Beliaev , Boris Ginsburg

Signal Temporal Logic (STL) has gained popularity in recent years as a specification language for cyber-physical systems, especially in robotics. Beyond being expressive and easy to understand, STL is appealing because the synthesis…

Robotics · Computer Science 2020-11-17 Vince Kurtz , Hai Lin

Tandem duplication is the process of inserting a copy of a segment of DNA adjacent to the original position. Motivated by applications that store data in living organisms, Jain et al. (2017) proposed the study of codes that correct tandem…

Information Theory · Computer Science 2018-01-09 Yeow Meng Chee , Johan Chrisnata , Han Mao Kiah , Tuan Thanh Nguyen

Extracting Times of Arrival from pulsar radio signals depends on the knowledge of the pulsars pulse profile and how this template is generated. We examine pulsar template generation with Bayesian methods. We will contrast the classical…

Instrumentation and Methods for Astrophysics · Physics 2015-06-23 M. Imgrund , D. J. Champion , M. Kramer , H. Lesch

Dynamic mode decomposition (DMD) has become a powerful data-driven method for analyzing the spatiotemporal dynamics of complex, high-dimensional systems. However, conventional DMD methods are limited to matrix-based formulations, which…

Systems and Control · Electrical Eng. & Systems 2025-08-05 Ziqin He , Mengqi Hu , Yifei Lou , Can Chen

Incremental text-to-speech (TTS) synthesis generates utterances in small linguistic units for the sake of real-time and low-latency applications. We previously proposed an incremental TTS method that leverages a large pre-trained language…

Sound · Computer Science 2021-09-23 Takaaki Saeki , Shinnosuke Takamichi , Hiroshi Saruwatari

Diffusion models are the go-to method for Text-to-Image generation, but their iterative denoising processes has high inference latency. Quantization reduces compute time by using lower bitwidths, but applies a fixed precision across all…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Basile Lewandowski , Simon Kurz , Aditya Shankar , Robert Birke , Jian-Jia Chen , Lydia Y. Chen
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