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Test-time adaptation (TTA) updates the model weights during the inference stage using testing data to enhance generalization. However, this practice exposes TTA to adversarial risks. Existing studies have shown that when TTA is updated with…

Machine Learning · Computer Science 2025-03-03 Yongyi Su , Yushu Li , Nanqing Liu , Kui Jia , Xulei Yang , Chuan-Sheng Foo , Xun Xu

Active Test-Time Adaptation (ATTA) improves model robustness under domain shift by selectively querying human annotations at deployment, but existing methods use heuristic uncertainty measures and suffer from low data selection efficiency,…

Machine Learning · Computer Science 2025-10-01 Tingyu Shi , Fan Lyu , Shaoliang Peng

The conditional average treatment effect (CATE) is the best measure of individual causal effects given baseline covariates. However, the CATE only captures the (conditional) average, and can overlook risks and tail events, which are…

Machine Learning · Statistics 2025-06-05 Nathan Kallus , Miruna Oprescu

This paper analyzes difference-in-differences designs with a continuous treatment. We show that treatment-on-the-treated-type parameters are identified under a parallel trends assumption analogous to the binary treatment case. However,…

Econometrics · Economics 2026-01-05 Brantly Callaway , Andrew Goodman-Bacon , Pedro H. C. Sant'Anna

There is increasing interest in combining information from experimental studies, including randomized and single-group trials, with information from external experimental or observational data sources. Such efforts are usually motivated by…

Methodology · Statistics 2026-04-23 Lawson Ung , Guanbo Wang , Sebastien Haneuse , Miguel A. Hernán , Issa J. Dahabreh

We consider the problem of estimating the average treatment effect (ATE) when both randomized control trial (RCT) data and external real-world data (RWD) are available. We decompose the ATE estimand as the difference between a pooled-ATE…

Methodology · Statistics 2025-01-22 Mark van der Laan , Sky Qiu , Jens Magelund Tarp , Lars van der Laan

Understanding treatment effect heterogeneity has become an increasingly popular task in various fields, as it helps design personalized advertisements in e-commerce or targeted treatment in biomedical studies. However, most of the existing…

Methodology · Statistics 2024-07-12 Waverly Wei , Xinwei Ma , Jingshen Wang

While randomized controlled trials (RCTs) are the gold standard for estimating treatment effects in medical research, there is increasing use of and interest in using real-world data for drug development. One such use case is the…

Methodology · Statistics 2021-10-11 Devin Incerti , Michael T Bretscher , Ray Lin , Chris Harbron

Numerous algorithms have been developed for Conditional Average Treatment Effect (CATE) estimation. In this paper, we first highlight a common issue where many algorithms exhibit inconsistent learning behavior for the same instance across…

Machine Learning · Computer Science 2025-07-08 Yi-Fu Fu , Keng-Te Liao , Shou-De Lin

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

A dynamic treatment regime is a sequence of treatment decision rules tailored to an individual's evolving status over time. In precision medicine, much focus has been placed on finding an optimal dynamic treatment regime which, if followed…

Other Statistics · Statistics 2025-10-13 Chunyu Wang , Brian DM Tom

This article develops a continuous-time asymptotic framework for analyzing adaptive experiments -- settings in which data collection and treatment assignment evolve dynamically in response to incoming information. A key challenge in…

Econometrics · Economics 2026-02-26 Karun Adusumilli

Adaptive treatment assignment algorithms, such as bandit algorithms, are increasingly used in digital health intervention clinical trials. Frequently, the data collected from these trials is used to conduct causal inference and related data…

Methodology · Statistics 2025-10-30 Kelly W. Zhang , Nowell Closser , Anna L. Trella , Susan A. Murphy

There has been a growing trend that activities relating to clinical trials take place at locations other than traditional trial sites (hence decentralized clinical trials or DCTs), some of which are at settings of real-world clinical…

This paper proposes a novel online evaluation protocol for Test Time Adaptation (TTA) methods, which penalizes slower methods by providing them with fewer samples for adaptation. TTA methods leverage unlabeled data at test time to adapt to…

Recently, test time adaptation (TTA) has attracted increasing attention due to its power of handling the distribution shift issue in the real world. Unlike what has been developed for convolutional neural networks (CNNs) for image data, TTA…

Machine Learning · Computer Science 2022-08-22 Guanzi Chen , Jiying Zhang , Xi Xiao , Yang Li

Deep learning models have demonstrated exceptional performance across a wide range of computer vision tasks. However, their performance often degrades significantly when faced with distribution shifts, such as domain or dataset changes.…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Samuel Barbeau , Pedram Fekri , David Osowiechi , Ali Bahri , Moslem Yazdanpanah , Masih Aminbeidokhti , Christian Desrosiers

Dynamic treatment regimes (DTRs) are personalized, adaptive, multi-stage treatment plans that adapt treatment decisions both to an individual's initial features and to intermediate outcomes and features at each subsequent stage, which are…

Machine Learning · Statistics 2022-09-22 Yichun Hu , Nathan Kallus

Reuse of data in adaptive workflows poses challenges regarding overfitting and the statistical validity of results. Previous work has demonstrated that interacting with data via differentially private algorithms can mitigate overfitting,…

Machine Learning · Computer Science 2025-11-13 Neil G. Marchant , Benjamin I. P. Rubinstein

For Internet applications like sponsored search, cautions need to be taken when using machine learning to optimize their mechanisms (e.g., auction) since self-interested agents in these applications may change their behaviors (and thus the…

Machine Learning · Computer Science 2014-10-14 Haifang Li , Fei Tian , Wei Chen , Tao Qin , Tie-Yan Liu