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Modulated electron radiotherapy (MERT) and combined, modulated photon/electron radiotherapy (MPERT) have received increased research attention, having shown capacity for reduced low dose exposure to healthy tissue and comparable, if not…

Medical Physics · Physics 2014-10-10 Samantha A. M. Lloyd , Isabelle M. Gagne , Sergei Zavgorodni

Monte Carlo (MC) simulation of linacs depends on the accurate geometrical description of the head. The geometry of the Varian TrueBeam (TB) linac is not available to researchers. Instead, the company distributes phase-space files (PSFs) of…

Monte Carlo (MC) simulation is considered as the most accurate method for radiation dose calculations. Accuracy of a source model for a linear accelerator is critical for the overall dose calculation accuracy. In this paper, we presented an…

Medical Physics · Physics 2015-03-06 Zhen Tian , Yongbao Li , Michael Folkerts , Feng Shi , Steve B. Jiang , Xun Jia

Purpose: To investigate the validity of two Monte Carlo simulation absolute dosimetry approaches in the case of a small field dedicated `D'-shaped collimator used for the retinoblastoma treatment with external photon beam radiotherapy.…

Medical Physics · Physics 2018-09-25 P. A. Mayorga , L. Brualla , A. Flühs , W. Sauerwein , A. M. Lallena

Flattening filter free (FFF) beams due to their non-uniformity, are sub-optimal for larger field sizes. The purpose of this study was to investigate the incident electron beam distributions that would produce flat FFF beams without the use…

Medical Physics · Physics 2015-06-16 Sergei Zavgorodni

A novel approach of accurately reconstructing storage ring's linear optics from turn-by-turn (TbT) data containing measurement error is introduced. This approach adopts a Bayesian inference based on the Markov Chain Monte-Carlo (MCMC)…

Accelerator Physics · Physics 2019-07-01 Yue Hao , Yongjun Li , Michael Balcewicz , Leo Neufcourt , Weixing Cheng

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…

Standard 6 megavolt (MV) radiotherapy is limited by source size and secondary electron range to minimum radiological penumbra widths of ~2-3 mm. This study investigates sharper beams via upright radiotherapy with lower energies and extended…

Medical Physics · Physics 2026-03-10 Lloyd E Kamole Ghomsi , Clinton Gibson , Veng-Jean Heng , Ramish M Ashraf , Lawrie Skinner

In this article we consider Bayesian estimation of static parameters for a class of partially observed McKean-Vlasov diffusion processes with discrete-time observations over a fixed time interval. This problem features several obstacles to…

Computation · Statistics 2025-04-23 Ajay Jasra , Amin Wu

Purpose: To evaluate the latent variance (LV) of TrueBeam photon phase-space files (PSF) for open 10x10$cm^2$ and small fields. Methods: BEAMnrc/DOSXYZnrc was used to transport particles from Varian phase-space files (PSFA) through the…

Medical Physics · Physics 2018-01-17 Eyad Alhakeem , Sergei Zavgorodni

This study develops and validates a patient-specific Monte Carlo (MC) dosimetry framework for propagation-based phase-contrast breast CT (BCT) at the Imaging and Medical Beamline (IMBL), ANSTO Australian Synchrotron, for accurate mean…

PURPOSE: Permanent breast seed implant (PBSI) using 103Pd is emerging as an effective adjuvant radiation technique for early-stage breast cancer. However, clinical dose evaluations follow the water-based TG-43 approach with its considerable…

Medical Physics · Physics 2021-05-27 Stephen G. Deering , Michelle Hilts , Deidre Batchelar , Juanita Crook , Rowan M. Thomson

Purpose: Retinoblastoma (RB) is the most common eye tumor in childhood and can be treated external radiotherapy. The purpose of this work is to evaluate the adequacy of Monte Carlo simulations and the accuracy of a commercial treatment…

Medical Physics · Physics 2018-09-26 L. Brualla , P. A. Mayorga , A. Flühs , A. M. Lallena , J. Sempau , W. Sauerwein

Purpose: To develop a Monte Carlo (MC) therapeutic dose calculation toolkit of a recently released ring gantry linac in Geant4 (Version 10.7) for secondary dose validation of radiotherapy plan. Methods: For the Halcyon (Varian Medical…

Medical Physics · Physics 2022-10-04 Ruirui Liu , Zhen Ji , Xiandong Zhao , Tianyu Zhao , Abhishek Sethi , Daren Sawkey , Bin Cai

Purpose: A Monte Carlo (MC) beam model and its implementation in a clinical treatment planning system (TPS, Varian Eclipse) are presented for a modified ultra-high dose-rate electron FLASH radiotherapy (eFLASH-RT) LINAC. Methods: The gantry…

Bayesian methods are commonly applied to solve image analysis problems such as noise-reduction, feature enhancement and object detection. A primary limitation of these approaches is the computational complexity due to the interdependence of…

Methodology · Statistics 2023-06-01 Konstantinos Bakas , John Kornak , Hernando Ombao

We present a fast and scalable estimator for the binned multi-frequency angular bispectrum (MABS) and the 3D bispectrum (BS) of the redshifted 21 cm signal from radio interferometric observations. The estimator operates on gridded…

Cosmology and Nongalactic Astrophysics · Physics 2025-06-13 Sukhdeep Singh Gill , Somnath Bharadwaj

This paper presents a new Bayesian model and algorithm used for depth and intensity profiling using full waveforms from the time-correlated single photon counting (TCSPC) measurement in the limit of very low photon counts. The model…

Applications · Statistics 2016-04-20 Yoann Altmann , Ximing Ren , Aongus McCarthy , Gerald S. Buller , Steve McLaughlin

In superconducting linear accelerators (linacs), accurately monitoring beam dynamics is essential for minimizing beam losses and ensuring stable operations. However, destructive diagnostics must be avoided in superconducting sections to…

Computed Tomography (CT) imaging, while essential for diagnostics, exposes patients to ionizing radiation. To accurately quantify radiation dosage, this study introduces MIDSX, a specialized open-source Monte Carlo (MC) photon transport…

Medical Physics · Physics 2023-11-29 John Meneghini
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