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We propose a new sequencing protocol that combines recent advances in combinatorial pooling design and second-generation sequencing technology to efficiently approach de novo selective genome sequencing. We show that combinatorial pooling…

Detection of rare variants by resequencing is important for the identification of individuals carrying disease variants. Rapid sequencing by new technologies enables low-cost resequencing of target regions, although it is still prohibitive…

Genomics · Quantitative Biology 2009-09-03 Noam Shental , Amnon Amir , Or Zuk

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

In this paper, we demonstrate some applications of compressive sensing over networks. We make a connection between compressive sensing and traditional information theoretic techniques in source coding and channel coding. Our results provide…

Information Theory · Computer Science 2010-12-07 Soheil Feizi , Muriel Medard , Michelle Effros

Coded compressed sensing is an algorithmic framework tailored to sparse recovery in very large dimensional spaces. This framework is originally envisioned for the unsourced multiple access channel, a wireless paradigm attuned to…

Information Theory · Computer Science 2019-10-23 Vamsi K. Amalladinne , Jean-Francois Chamberland , Krishna R. Narayanan

Decoding sequences that stem from multiple transmissions of a codeword over an insertion, deletion, and substitution channel is a critical component of efficient deoxyribonucleic acid (DNA) data storage systems. In this paper, we consider a…

Information Theory · Computer Science 2022-09-13 Issam Maarouf , Andreas Lenz , Lorenz Welter , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

This paper considers the problem of distributed source coding for a large network. A major obstacle that poses an existential threat to practical deployment of conventional approaches to distributed coding is the exponential growth of the…

Information Theory · Computer Science 2013-01-08 Kumar Viswanatha , Sharadh Ramaswamy , Ankur Saxena , Emrah Akyol , Kenneth Rose

This article introduces a novel communication scheme, termed coded compressed sensing, for unsourced multiple-access communication. The proposed divide-and-conquer approach leverages recent advances in compressed sensing and forward error…

Signal Processing · Electrical Eng. & Systems 2019-06-26 Vamsi K. Amalladinne , Jean-Francois Chamberland , Krishna R. Narayanan

We introduce a recursive algorithm for performing compressed sensing on streaming data. The approach consists of a) recursive encoding, where we sample the input stream via overlapping windowing and make use of the previous measurement in…

Machine Learning · Statistics 2013-12-18 Nikolaos M. Freris , Orhan Öçal , Martin Vetterli

Acquiring genomes at single-cell resolution has many applications such as in the study of microbiota. However, deep sequencing and assembly of all of millions of cells in a sample is prohibitively costly. A property that can come to rescue…

Genomics · Quantitative Biology 2014-04-29 Zeinab Taghavi

In its most elementary form, compressed sensing studies the design of decoding algorithms to recover a sufficiently sparse vector or code from a lower dimensional linear measurement vector. Typically it is assumed that the decoder has…

Machine Learning · Computer Science 2021-07-20 Michael Murray , Jared Tanner

In this paper we describe a new technique for the comparison of populations of DNA strands. Comparison is vital to the study of ecological systems, at both the micro and macro scales. Existing methods make use of DNA sequencing and cloning,…

Biomolecules · Quantitative Biology 2008-07-02 Dennis Shasha , Martyn Amos

Decoding sequences that stem from multiple transmissions of a codeword over an insertion, deletion, and substitution channel is a critical component of efficient deoxyribonucleic acid (DNA) data storage systems. In this paper, we consider a…

Information Theory · Computer Science 2020-10-30 Andreas Lenz , Issam Maarouf , Lorenz Welter , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

Compressed sensing is a signal processing method that acquires data directly in a compressed form. This allows one to make less measurements than what was considered necessary to record a signal, enabling faster or more precise measurement…

Statistical Mechanics · Physics 2012-08-20 Florent Krzakala , Marc Mézard , François Sausset , Yifan Sun , Lenka Zdeborová

To increase the information capacity of DNA storage, composite DNA letters were introduced. We propose a novel channel model for composite DNA in which composite sequences are decomposed into ordered standard non-composite sequences. The…

Information Theory · Computer Science 2025-10-31 Besart Dollma , Ohad Elishco , Eitan Yaakobi

Unsourced random access (URA) has emerged as a pragmatic framework for next-generation distributed sensor networks. Within URA, concatenated coding structures are often employed to ensure that the central base station can accurately recover…

Information Theory · Computer Science 2021-12-02 Vamsi K. Amalladinne , Jamison R. Ebert , Jean-Francois Chamberland , Krishna R. Narayanan

Modern compression algorithms exploit complex structures that are present in signals to describe them very efficiently. On the other hand, the field of compressed sensing is built upon the observation that "structured" signals can be…

Information Theory · Computer Science 2016-01-08 Farideh Ebrahim Rezagah , Shirin Jalali , Elza Erkip , H. Vincent Poor

Compressed Sensing decoding algorithms can efficiently recover an N dimensional real-valued vector x to within a factor of its best k-term approximation by taking m = 2klog(N/k) measurements y = Phi x. If the sparsity or approximate…

Numerical Analysis · Mathematics 2008-12-09 Rachel Ward

Constrained sequence codes have been widely used in modern communication and data storage systems. Sequences encoded with constrained sequence codes satisfy constraints imposed by the physical channel, hence enabling efficient and reliable…

Information Theory · Computer Science 2018-09-07 Congzhe Cao , Duanshun Li , Ivan Fair
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