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Size and shape are critical discriminators between molecular species and states. We describe a micro-chip based high-throughput imaging approach offering rapid and precise determination of molecular properties under native solution…

The decomposition method which makes the parallel solution of the block-tridiagonal matrix systems possible is presented. The performance of the method is analytically estimated based on the number of elementary multiplicative operations…

Computational Physics · Physics 2015-05-27 P. A. Belov , E. R. Nugumanov , S. L. Yakovlev

The success of metabolomics studies depends upon the "fitness" of each biological sample used for analysis: it is critical that metabolite levels reported for a biological sample represent an accurate snapshot of the studied organism's…

Quantitative Methods · Quantitative Biology 2015-06-16 Barry M. Slaff , Shane T. Jensen , Aalim M. Weljie

Finding sparse solutions of underdetermined systems of linear equations is a fundamental problem in signal processing and statistics which has become a subject of interest in recent years. In general, these systems have infinitely many…

Machine Learning · Statistics 2010-09-21 Arash Ali Amini , Massoud Babaie-Zadeh , Christian Jutten

To understand the system-wide organization of metabolism, different lines of study have devised different categorizations of metabolites. The relationship and difference between categories can provide new insights for a more detailed…

Molecular Networks · Quantitative Biology 2009-07-24 Jing Zhao , Petter Holme

When addressing spatial biological questions using mathematical models, symmetries within the system are often exploited to simplify the problem by reducing its physical dimension. In a reduced-dimension model molecular movement is…

Quantitative Methods · Quantitative Biology 2025-02-17 Natasha S. Savage

Untargeted metabolomics based on liquid chromatography-mass spectrometry technology is quickly gaining widespread application given its ability to depict the global metabolic pattern in biological samples. However, the data is noisy and…

Methodology · Statistics 2026-03-24 Guoxuan Ma , Jian Kang , Tianwei Yu

Ultrafast multidimensional spectroscopies are powerful tools that can access charge and energy flow in complex materials, shifting chemical kinetics, and even many-body interactions in correlated matter. However, current implementations…

Numerous algorithms and parallelisations have been developed for short-range particle simulations; however, none are optimally performant for all scenarios. Such a concept led to the prior development of the particle simulation library…

Computational Engineering, Finance, and Science · Computer Science 2025-05-07 Samuel James Newcome , Fabio Alexander Gratl , Manuel Lerchner , Abdulkadir Pazar , Manish Kumar Mishra , Hans-Joachim Bungartz

We introduce a machine learning model to predict atomization energies of a diverse set of organic molecules, based on nuclear charges and atomic positions only. The problem of solving the molecular Schr\"odinger equation is mapped onto a…

Single-particle tracking (SPT) has become a popular tool to study the intracellular transport of molecules in living cells. Inferring the character of their dynamics is important, because it determines the organization and functions of the…

Quantitative Methods · Quantitative Biology 2020-09-09 Joanna Janczura , Patrycja Kowalek , Hanna Loch-Olszewska , Janusz Szwabiński , Aleksander Weron

Magnetic Resonance Spectroscopic Imaging (MRSI) is a clinical imaging modality for measuring tissue metabolite levels in-vivo. An accurate estimation of spectral parameters allows for better assessment of spectral quality and metabolite…

Computer Vision and Pattern Recognition · Computer Science 2018-05-28 Dhritiman Das , Eduardo Coello , Rolf F Schulte , Bjoern H Menze

An improved characteristic set algorithm for solving Boolean polynomial systems is proposed. This algorithm is based on the idea of converting all the polynomials into monic ones by zero decomposition, and using additions to obtain…

Symbolic Computation · Computer Science 2019-11-12 Zhenyu Huang , Yao Sun , Dongdai Lin

To obtain an electron-density map from a macromolecular crystal the phase-problem needs to be solved, which often involves the use of heavy-atom derivative crystals and concomitantly the determination of the heavy atom substructure. This is…

Biomolecules · Quantitative Biology 2018-08-20 Bjørn Panyella Pedersen , Pontus Gourdon , Xiangyu Liu , Jesper Lykkegaard Karlsen , Poul Nissen

In order to obtain a good understanding of astrochemistry, it is crucial to better understand the key parameters that govern grain-surface chemistry. For many chemical networks, these crucial parameters are the binding energies of the…

Astrophysics of Galaxies · Physics 2023-06-12 Johannes Heyl , Serena Viti , Gijs Vermariën

Any CNF formula can be decomposed two blocked subsets such that both can be solved by BCE (Blocked Clause Elimination). To make the decomposition more useful, one hopes to have the decomposition as unbalanced as possible. It is often time…

Logic in Computer Science · Computer Science 2015-12-22 Jingchao Chen

Molecular "fingerprints" encoding structural information are the workhorse of cheminformatics and machine learning in drug discovery applications. However, fingerprint representations necessarily emphasize particular aspects of the…

Machine Learning · Statistics 2016-08-26 Steven Kearnes , Kevin McCloskey , Marc Berndl , Vijay Pande , Patrick Riley

A systematic method for determining order parameters for quantum many-body systems on lattices is developed by utilizing reduced density matrices. This method allows one to extract the order parameter directly from the wave functions of the…

Strongly Correlated Electrons · Physics 2007-05-23 Shunsuke Furukawa , Gregoire Misguich , Masaki Oshikawa

Tandem mass spectra capture fragmentation patterns that provide key structural information about a molecule. Although mass spectrometry is applied in many areas, the vast majority of small molecules lack experimental reference spectra. For…

Machine Learning · Computer Science 2023-05-03 Adamo Young , Bo Wang , Hannes Röst

Background: Understanding the relationship between the Omics and the phenotype is a central problem in precision medicine. The high dimensionality of metabolomics data challenges learning algorithms in terms of scalability and…

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