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Parkinson's disease is a progressive and slowly developing neurodegenerative disease, characterized by dopaminergic neuron loss in the substantia nigra region of the brain. Despite extensive research by scientists, there is not yet a cure…

Quantitative Methods · Quantitative Biology 2024-08-31 Pratham Kankariya , Rachita Rode , Kevin Mudaliar , Pranali Hatode

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair…

Machine Learning · Computer Science 2025-04-07 Masahiro Matsumoto , Abu Saleh Musa Miah , Nobuyoshi Asai , Jungpil Shin

In this study, we executed a genomic analysis with the objective of selecting a set of genes (possibly small) that would help in the detection and classification of samples from patients affected by Parkinson Disease. We performed a…

Machine Learning · Computer Science 2016-02-24 Giancarlo Crocetti , Michael Coakley , Phil Dressner , Wanda Kellum , Tamba Lamin

Parkinsons disease is the second most prevalent neurodegenerative disorder with over ten million active cases worldwide and one million new diagnoses per year. Detecting and subsequently diagnosing the disease is challenging because of…

Computation and Language · Computer Science 2024-04-09 Jonathan Crawford

Parkinson's Disease(PD) is one of the major nervous system disorders that affect people over 60. PD can cause cognitive impairments. In this work, we explore various approaches to identify Parkinson's using Magnetic Resonance (MR) T1 images…

Image and Video Processing · Electrical Eng. & Systems 2020-07-03 Tahjid Ashfaque Mostafa , Irene Cheng

Parkinson's disease (PD) is a common and complex neurodegenerative disorder with 5 stages in the Hoehn and Yahr scaling. Given the heterogeneity of PD, it is challenging to classify early stages 1 and 2 and detect brain function…

Neurons and Cognition · Quantitative Biology 2022-07-22 Xueqi Guo , Sule Tinaz , Nicha C. Dvornek

This study addresses the challenges of symptom evolution complexity and insufficient temporal dependency modeling in Parkinson's disease progression prediction. It proposes a unified prediction framework that integrates structural…

Machine Learning · Computer Science 2025-08-22 Jiacheng Hu , Bo Zhang , Ting Xu , Haifeng Yang , Min Gao

Parkinson's disease (PD) is a progressive neurological disorder that impairs movement control, leading to symptoms such as tremors, stiffness, and bradykinesia. Many researchers analyzing handwriting data for PD detection typically rely on…

Signal Processing · Electrical Eng. & Systems 2024-12-25 Jungpil Shin , Abu Saleh Musa Miah , Koki Hirooka , Md. Al Mehedi Hasan , Md. Maniruzzaman

Parkinson's disease (PD) is one of the major public health problems in the world. It is a well-known fact that around one million people suffer from Parkinson's disease in the United States whereas the number of people suffering from…

Machine Learning · Computer Science 2016-10-27 Kamal Nayan Reddy Challa , Venkata Sasank Pagolu , Ganapati Panda , Babita Majhi

Parkinson's Disease (PD) is characterized by disorders in motor function such as freezing of gait, rest tremor, rigidity, and slowed and hyposcaled movements. Medication with dopaminergic medication may alleviate those motor symptoms,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-09 Terry Taewoong Um , Franz Michael Josef Pfister , Daniel Christian Pichler , Satoshi Endo , Muriel Lang , Sandra Hirche , Urban Fietzek , Dana Kulić

A transcriptome-wide blood expression dataset of Parkinson's disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of…

Cell Behavior · Quantitative Biology 2010-03-30 André X. C. N. Valente , Jorge A. B. Sousa , Tiago F. Outeiro , Lino Ferreira

Parkinson's disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Objective measurements of motor signs are of vital importance for diagnosing, monitoring and developing disease modifying…

Parkinson's disease (PD) is a debilitating neurodegenerative disease that has severe impacts on an individual's quality of life. Compared with structural and functional MRI-based biomarkers for the disease, electroencephalography (EEG) can…

Machine Learning · Computer Science 2024-08-05 Christopher Neves , Yong Zeng , Yiming Xiao

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

Parkinson's disease (PD) is a non-curable disease that commonly found among elders that greatly reduce their quality of life. PD primarily affects the gait pattern and slowly changes the walking gait from the normality to disability. The…

Machine Learning · Computer Science 2021-02-02 Musthaq Ahamed , P. D. S. H. Gunawardane , Nimali T. Medagedara

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system characterized by motor and non-motor symptoms. As the disease progresses, patients alternate periods in which motor symptoms are mitigated due to…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-26 Anna Pompili , Rubén Solera-Ureña , Alberto Abad , Rita Cardoso , Isabel Guimarães , Margherita Fabbri , Isabel P. Martins , Joaquim Ferreira

Parkinson's disease (PD) is a progressive neurodegenerative disorder that impacts motor functions and speech characteristics This study focuses on differentiating individuals with Parkinson's disease from healthy controls through the…

Machine Learning · Computer Science 2025-01-27 Burak Çelik , Ayhan Akbal

Despite the promising performance of state of the art approaches for Parkinsons Disease (PD) detection, these approaches often analyze individual speech segments in isolation, which can lead to suboptimal results. Dysarthric cues that…

Machine Learning · Computer Science 2024-09-17 Shakeel A. Sheikh , Yacouba Kaloga , Md Sahidullah , Ina Kodrasi

Parkinson's disease (PD) is a chronic and complex neurodegenerative disorder influenced by genetic, clinical, and lifestyle factors. Predicting this disease early is challenging because it depends on traditional diagnostic methods that face…

Machine Learning · Computer Science 2026-04-21 Md Mezbahul Islam , John Michael Templeton , Masrur Sobhan , Christian Poellabauer , Ananda Mohan Mondal

One major challenge in the medication of Parkinson's disease is that the severity of the disease, reflected in the patients' motor state, cannot be measured using accessible biomarkers. Therefore, we develop and examine a variety of…

Machine Learning · Computer Science 2019-04-26 Jann Goschenhofer , Franz MJ Pfister , Kamer Ali Yuksel , Bernd Bischl , Urban Fietzek , Janek Thomas