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Proton and carbon ion therapy is an emerging technique used for the treatment of solid cancers. The monitoring of the dose delivered during such treatments is still a matter of research. A possible technique exploits the information…

Monte Carlo simulations have been performed in order to evaluate the efficiencies of several light ions identification techniques. The detection system was composed with layers of scintillating material to measure either the deposited…

Nuclear Experiment · Physics 2013-10-02 S. Salvador , M. Labalme , J. M. Fontbonne , J. Dudouet , J. Colin , D. Cussol

Prompt Gamma Timing (PGT) is a promising technique for in vivo range verification in particle therapy, exploiting the time-of-flight between primary particles and prompt gamma rays emitted by nuclear interactions. PGT distribution is highly…

By means of a time-of-flight technique, we measured the longitudinal profile of prompt $\gamma$-rays emitted by 73 MeV/u $^{13}$C ions irradiating a PMMA target. This technique allowed us to minimize the shielding against neutrons and…

Hadrontherapy is an emerging technique in cancer therapy that uses beams of charged particles. To meet the improved capability of hadrontherapy in matching the dose release with the cancer position, new dose monitoring techniques need to be…

In the context of range monitoring for particle therapy, this study presents the first experimental results obtained with the TIARA detector using carbon-ion beams at the CNAO clinical center in Pavia, Italy. TIARA is based on the Prompt…

Charged particle beams are used in Particle Therapy (PT) to treat oncological patients due to their selective dose deposition in tissues and to their high biological effect in killing cancer cells with respect to photons and electrons used…

Proton and carbon ion therapy is an emerging technique used for the treatment of solid cancers. The monitoring of the dose delivered during such treatments and the on-line knowledge of the Bragg peak position is still a matter of research.…

We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…

Gamma-ray continuum at > 10 MeV photon energy yields information on > 0.2 - 0.3 GeV/nucleon ions at the Sun. We use the general-purpose Monte Carlo code FLUKA (FLUktuierende KAskade) to model the transport of ions injected into thick and…

High Energy Astrophysical Phenomena · Physics 2020-12-16 A L MacKinnon , S. Szpigel , G. Gimenez de Castro , J Tuneu

We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the…

Medical Physics · Physics 2016-08-25 L. Giuffrida , D. Margarone , G. A. P. Cirrone , A. Picciotto , G. Korn

Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and…

Carbon ion is the mostly common used particle in heavy ion radiotherapy. In this paper, carbon ion dose in tumor treatment for human eye was simulated with FLUKA code, 80 MeV/u carbon beam was irradiated into the human eye from two…

Medical Physics · Physics 2015-06-18 Chengguo Pang , Youwu Su , Zeen Yao , Junkui Xu , Wuyuan Li , Jiao Yuan

The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…

Medical Physics · Physics 2025-04-01 Magdalena Kołodziej

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection system consists of eight LaBr3 scintillators and a tungsten collimator,…

Microdosimetric single event spectra is a significant parameter in radiotherapy, which can be used to evaluate the biological effect of radiation fields. This paper simulated microscopic patterns of energy depositions for mixed radiation…

Medical Physics · Physics 2015-02-03 Chengguo Pang , Junkui Xu , Wuyuan Li , Weiwei Yan , Zeen Yao , Youwu Su

The paper discusses some 3D simulations to compute the ionizing radiation dose during laser-plasma experiments leading to the generation of accelerated protons and electrons. Also, we suggest a new method to increase the measurement…

Instrumentation and Detectors · Physics 2019-10-02 M. Ganciu , A. Chirosca , A. Groza , E. Stancu , O. Stoican , D. B. Dreghici , B. Butoi , C. Ticos , B. Mihalcea , B. Cramariuc

In carbon-therapy, the interaction of the incoming beam with human tissues may lead to the production of a large amount of nuclear fragments and secondary light particles. An accurate estimation of the biological dose deposited into the…

Nuclear Experiment · Physics 2014-06-02 J. Dudouet , D. Cussol , D. Durand , M. Labalme

In this work, we propose a novel technique for in-vivo proton therapy range verification. This technique makes use of a small hadron tumour marker, $^{92}$Mo, implanted at a short known distance from the clinical treatment volume. Signals…

Carbon ion therapy is one of the most advanced forms of radiotherapy, promising improved efficacy against resistant cancers. However, the high precision offered by the carbon ion Bragg peak requires precise knowledge of the beam range…

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