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More than any other species, humans form social ties to individuals who are neither kin nor mates, and these ties tend to be with similar people. Here, we show that this similarity extends to genotypes. Across the whole genome, friends'…

Genomics · Quantitative Biology 2014-12-05 Nicholas A. Christakis , James H. Fowler

A classical problem of statistical inference is the valid specification of a model that can account for the statistical dependencies between observations when the true structure is dense, intractable, or unknown. To address this problem, a…

Statistics Theory · Mathematics 2023-10-19 Shane Sparkes , Lu Zhang

We consider the problem of testing whether pairs of univariate random variables are associated. Few tests of independence exist that are consistent against all dependent alternatives and are distribution free. We propose novel tests that…

Methodology · Statistics 2014-12-09 Ruth Heller , Yair Heller , Shachar Kaufman , Malka Gorfine

We present easily verifiable sufficient conditions of time-independence and commutativity for local and nonlocal symmetries for a large class of homogeneous (1+1)-dimensional evolution systems. In contrast with the majority of known…

Exactly Solvable and Integrable Systems · Physics 2007-05-23 A. Sergyeyev

When do syzygies depend on the characteristic of the field? Even for well-studied families of examples, very little is known. For a family of random monomial ideals, namely the Stanley--Reisner ideals of random flag complexes, we prove that…

Commutative Algebra · Mathematics 2021-01-08 Caitlyn Booms , Daniel Erman , Jay Yang

Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the new mutation. In this paper, we are interested in…

Probability · Mathematics 2016-11-28 Charline Smadi

We consider $N\times N$ Hermitian random matrices with independent identically distributed entries (Wigner matrices). The matrices are normalized so that the average spacing between consecutive eigenvalues is of order $1/N$. Under suitable…

Mathematical Physics · Physics 2009-05-13 Laszlo Erdos , Benjamin Schlein , Horng-Tzer Yau

Myriad articles are devoted to Mertens's theorem. In yet another, we merely wish to draw attention to a proof by Hardy, which uses a Tauberian theorem of Landau that "leads to the conclusion in a direct and elegant manner". Hardy's proof is…

Number Theory · Mathematics 2013-10-01 Mohammad Bardestani , Tristan Freiberg

Mendelian randomization uses genetic variants to make causal inferences about the effect of a risk factor on an outcome. With fine-mapped genetic data, there may be hundreds of genetic variants in a single gene region any of which could be…

Methodology · Statistics 2017-07-10 Stephen Burgess , Verena Zuber , Elsa Valdes-Marquez , Benjamin B Sun , Jemma C Hopewell

Consider a haploid population of fixed finite size with a finite number of allele types and having Cannings exchangeable genealogy with neutral mutation. The stationary distribution of the Markov chain of allele counts in each generation is…

Probability · Mathematics 2016-12-09 H. L. Gan , Adrian Röllin , Nathan Ross

We study a class of Cannings models with population size $N$ having a mixed multinomial offspring distribution with random success probabilities $W_1,\ldots,W_N$ induced by independent and identically distributed positive random variables…

Probability · Mathematics 2021-10-01 Thierry Huillet , Martin Möhle

We prove a homological stability theorem for families of discrete groups (e.g. mapping class groups, automorphism groups of free groups, braid groups) with coefficients in a sequence of irreducible algebraic representations of arithmetic…

Algebraic Topology · Mathematics 2025-06-04 Jeremy Miller , Peter Patzt , Dan Petersen , Oscar Randal-Williams

We consider a population of particles with unit life length. Dying each particle produces offspring whose size depends on the random environment specifying the reproduction law of all particles of the given generation and on the number of…

Probability · Mathematics 2018-12-27 V. A. Vatutin , E. E. Dyakonova

Phylogenetic inference, the task of reconstructing how related sequences evolved from common ancestors, is a central objective in evolutionary genomics. The current state-of-the-art methods exploit probabilistic models of sequence evolution…

Populations and Evolution · Quantitative Biology 2026-02-19 Luc Blassel , Noémie Sauvage , Pierre Barrat-Charlaix , Bastien Boussau , Nicolas Lartillot , Laurent Jacob

Recent publications have described and applied a novel metric that quantifies the genetic distance of an individual with respect to two population samples, and have suggested that the metric makes it possible to infer the presence of an…

Genomics · Quantitative Biology 2015-09-24 Rosemary Braun , William Rowe , Carl Schaefer , Jinghui Zhang , Kenneth Buetow

Mixing maternal and paternal genomes is the base of plant sexual reproduction, but some so-called 'haploid inducer lines' lead to the formation of seeds bearing well-developed embryos with solely the maternal genome. A recent study adds a…

Subcellular Processes · Quantitative Biology 2022-10-07 Nathanaël Jacquier , Thomas Widiez

Some mathematical theorems represent ideas that are discovered again and again in different forms. One such theorem is Hall's marriage theorem. This theorem is equivalent to several other theorems in combinatorics and optimization theory,…

Combinatorics · Mathematics 2022-02-07 Twan Koperberg

Statistical learning relies upon data sampled from a distribution, and we usually do not care what actually generated it in the first place. From the point of view of causal modeling, the structure of each distribution is induced by…

Machine Learning · Computer Science 2018-09-11 Giambattista Parascandolo , Niki Kilbertus , Mateo Rojas-Carulla , Bernhard Schölkopf

Probabilistic independence is a useful concept for describing the result of random sampling---a basic operation in all probabilistic languages---and for reasoning about groups of random variables. Nevertheless, existing verification methods…

Programming Languages · Computer Science 2020-07-21 Gilles Barthe , Justin Hsu , Kevin Liao

We consider the random graph M^n_{\bar{p}} on the set [n], were the probability of {x,y} being an edge is p_{|x-y|}, and \bar{p}=(p_1,p_2,p_3,...) is a series of probabilities. We consider the set of all \bar{q} derived from \bar{p} by…

Logic · Mathematics 2010-06-16 Mor Doron , Saharon Shelah