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Related papers: Convective Replica-Exchange in Ergodic Regimes

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Replica exchange (RE) is one of the most popular enhanced-sampling simulations technique in use today. Despite widespread successes, RE simulations can sometimes fail to converge in practical amounts of time, e.g., when sampling around…

Statistical Mechanics · Physics 2021-05-13 Thomas Vogel , Danny Perez

We propose a new implementation of the replica-exchange method (REM) in which replicas follow a pre-planned route in temperature space instead of a random walk. Our method satisfies the detailed balance condition in the proposed route. The…

Statistical Mechanics · Physics 2015-09-22 Ryo Urano , Yuko Okamoto

Replica exchange (REX) is one of the most widely used enhanced sampling methodologies, yet its efficiency is limited by the requirement for a large number of intermediate temperature replicas. Here we present Generative Replica Exchange…

Biomolecules · Quantitative Biology 2026-03-20 Shengjie Huang , Sijie Yang , Jianqiao Yi , Rui Zheng , Haocong Liao , Muzammal Hussain , Yaoquan Tu , Xiaoyun Lu , Yang Zhou

The replica exchange method is a powerful tool for overcoming slow relaxation in molecular simulations, but its efficiency depends strongly on the choice of the number and interval of replicas and their exchange probabilities. Here, we…

Statistical Mechanics · Physics 2025-06-04 Akie Kowaguchi , Katsuhiro Endo , Kentaro Nomura , Shuichi Kurabayashi , Paul E. Brumby , Kenji Yasuoka

We recently introduced a novel replica-exchange scheme in which an individual replica can sample from states encountered by other replicas at any previous time by way of a global configuration database, enabling the fast propagation of…

Computational Physics · Physics 2015-12-15 Thomas Vogel , Danny Perez

Idealized convection-permitting simulations of radiative-convective equilibrium (RCE) have become a popular tool for understanding the physical processes leading to horizontal variability of tropical water vapor and rainfall. However, the…

Atmospheric and Oceanic Physics · Physics 2019-09-19 Tom Beucler , Tristan Abbott , Timothy Cronin , Michael Pritchard

We investigate to what extend the replica-exchange Monte Carlo method is able to equilibrate a simple liquid in its supercooled state. We find that this method does indeed allow to generate accurately the canonical distribution function…

Soft Condensed Matter · Physics 2009-10-31 Ryoichi Yamamoto , Walter Kob

Efficient computational methods that are capable of supporting experimental measures obtained at constant values of pH and redox potential are important tools as they serve to, among other things, provide additional atomic level information…

Chemical Physics · Physics 2018-09-21 Vinícius Wilian D. Cruzeiro , Adrian E. Roitberg

Replica exchange molecular dynamics (REMD) becomes more efficient as the frequency of swap between the temperatures is increased. Recently in [Plattner et al, J. Chem. Phys. 135, 134111 (2011)] a method was proposed to implement infinite…

Statistical Mechanics · Physics 2015-06-12 Jianfeng Lu , Eric Vanden-Eijnden

We propose an efficient Monte Carlo algorithm for simulating a ``hardly-relaxing" system, in which many replicas with different temperatures are simultaneously simulated and a virtual process exchanging configurations of these replica is…

Condensed Matter · Physics 2009-10-28 Koji Hukushima , Koji Nemoto

Relative free energy calculations are now widely used in academia and industry, but the accuracy is often limited by poor sampling of the complexes conformational ensemble. To address this, we have developed a novel method termed…

Chemical Physics · Physics 2025-08-12 Anika J. Friedman , Wei-Tse Hsu , Michael R. Shirts

We develop a novel method of replica-exchange molecular dynamics (REMD) simulation, mass-scaling REMD (MSREMD) method, which improves trajectory accuracy at high temperatures, and thereby contributes to numerical stability. In addition, the…

Statistical Mechanics · Physics 2015-06-19 Tetsuro Nagai , Takuya Takahashi

Nested sampling (NS) has emerged as a powerful tool for exploring thermodynamic properties in materials science. However, its efficiency is often hindered by the limitations of Markov chain Monte Carlo (MCMC) sampling. In strongly…

Statistical Mechanics · Physics 2025-07-31 Nico Unglert , Livia Bartók Pártay , Georg K. H. Madsen

The computational study of conformational transitions in RNA and proteins with atomistic molecular dynamics often requires suitable enhanced sampling techniques. We here introduce a novel method where concurrent metadynamics are integrated…

Computational Physics · Physics 2015-09-01 Alejandro Gil-Ley , Giovanni Bussi

In this work a replica exchange Monte Carlo scheme which considers an extended isobaric-isothermal ensemble with respect to pressure is applied to study hard spheres (HS). The idea behind the proposal is expanding volume instead of…

Statistical Mechanics · Physics 2015-05-20 Gerardo Odriozola

We developed a replica exchange method that is effectively parallelizable even if the computational cost of the Monte Carlo moves in the parallel replicas are considerably different, for instance, because the replicas run on different type…

Computational Physics · Physics 2023-01-11 Sander Roet , Daniel T. Zhang , Titus S. van Erp

In dealing with thermal transport in composite systems, high contrast materials pose a special problem for numerical simulation: the time scale or step size in the high conductivity material must be much smaller than in the low conductivity…

Materials Science · Physics 2010-11-15 K. G. S. H. Gunawardana , Kieran Mullen , Dimitrios V. Papavassiliou

We introduce an algorithm to systematically improve the efficiency of parallel tempering Monte Carlo simulations by optimizing the simulated temperature set. Our approach is closely related to a recently introduced adaptive algorithm that…

Other Condensed Matter · Physics 2007-05-23 Helmut G. Katzgraber , Simon Trebst , David A. Huse , Matthias Troyer

Replica Exchange (RE) simulations have emerged as an important algorithmic tool for the molecular sciences. RE simulations involve the concurrent execution of independent simulations which infrequently interact and exchange information. The…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-01-22 Antons Treikalis , Andre Merzky , Haoyuan Chen , Tai-Sung Lee , Darrin M. York , Shantenu Jha

Disruption-generated runaway electrons (RE) present an outstanding issue for ITER. The predictive computational studies of RE generation rely on orbit-averaged computations and, as such, they lack the effects from the magnetic field…

Plasma Physics · Physics 2017-01-19 Konsta Särkimäki , Eero Hirvijoki , Joan Decker , Jari Varje , Taina Kurki-Suonio
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