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Purpose: To develop a novel aperture-based algorithm for volumetric modulated arc therapy (VMAT) treatment plan optimization with high quality and high efficiency. Methods: The VMAT optimization problem is formulated as a large-scale convex…

Medical Physics · Physics 2015-05-19 Chunhua Men , H. Edwin Romeijn , Xun Jia , Steve B. Jiang

In recent years, volumetric modulated arc therapy (VMAT) has been becoming a more and more important radiation technique widely used in clinical application for cancer treatment. One of the key problems in VMAT is treatment plan…

Medical Physics · Physics 2016-01-06 Yu Yang , Bin Dong , Zaiwen Wen

In this article we provide a method to generate the trade-off between delivery time and fluence map matching quality for volumetric modulated arc therapy (VMAT). At the heart of our method lies a mathematical programming model that, for a…

Medical Physics · Physics 2017-03-08 Marleen Balvert , David Craft

Background and Purpose: Increasing the number of arcs in volumetric modulated arc therapy (VMAT) allows for better intensity modulation and may improve plan quality. However, this leads to longer delivery times, which may cause patient…

Medical Physics · Physics 2025-10-31 Nathan Torelli , Madalyne Day , Jan Unkelbach

In this first paper of a two-paper series, we present a method for optimizing the dynamic delivery of fluence maps in radiation therapy. For a given fluence map and a given delivery time, the optimization of the leaf trajectories of a…

Medical Physics · Physics 2016-08-10 David Craft , Marleen Balvert

Volumetric Modulated Arc Therapy (VMAT) is a cornerstone of modern radiation therapy, enabling highly conformal tumor irradiation and healthy-tissue sparing. Yet, its planning solves inverse and nested optimization for multi-leaf…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Isabella Poles , Simon Arberet , Riqiang Gao , Martin Kraus , Marco D. Santambrogio , Florin C. Ghesu , Ali Kamen , Dorin Comaniciu

Traditional VMAT optimization often ignores dynamic machine limits, treating delivery time as an emergent property rather than a steerable parameter. This work introduces Dynamic Modulated Arc Therapy (DMAT), an intent-driven framework that…

The purpose of this study is to give an exact formulation of optimization of volumetric-modulated arc therapy (VMAT) with sliding-window delivery, and to investigate the plan quality effects of decreasing the number of sliding-window sweeps…

Medical Physics · Physics 2018-10-23 Lovisa Engberg , Anders Forsgren

Purpose: To make the planning of volumetric modulated arc therapy (VMAT) faster and to explore the tradeoffs between planning objectives and delivery efficiency. Methods: A convex multicriteria dose optimization problem is solved for an…

Medical Physics · Physics 2015-05-28 David Craft , Dualta McQuaid , Jeremiah Wala , Wei Chen , Ehsan Salari , Thomas Bortfeld

Purpose: To improve the delivery efficiency of VMAT by extending the recently published VMAT treatment planning algorithm vmerge to automatically generate optimal partial-arc plans. Methods and materials: A high-quality initial plan is…

Medical Physics · Physics 2015-06-05 Jeremiah Wala , Ehsan Salari , Wei Chen , David Craft

Within the setting of intensity modulated radiation therapy (IMRT) and the fully continuous version of IMRT called volumetric modulated radiation therapy (VMAT), we consider the problem of matching a given fluence map as well as possible in…

Medical Physics · Physics 2019-01-14 Matthew Kelly , Jacobus H. M. van Amerongen , Marleen Balvert , David Craft

Volumetric Modulated Arc Therapy (VMAT) revolutionizes cancer treatment by precisely delivering radiation while sparing healthy tissues. Fluence maps generation, crucial in VMAT planning, traditionally involves complex and iterative, and…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Simon Arberet , Florin C. Ghesu , Riqiang Gao , Martin Kraus , Jonathan Sackett , Esa Kuusela , Ali Kamen

A new delivery option for cancer centers equipped with linear accelerators fitted with multi-leaf collimators (MLC) -- i.e. centers which can perform intensity modulated radiation therapy (IMRT) -- is rotational delivery. In rotational…

Medical Physics · Physics 2009-10-27 David Craft , Thomas Bortfeld

Collimator angle is usually rotated when planning volumetric modulated arc therapy (VMAT) due to the leakage of radiation between multi-leaf collimator (MLC) leaves. We studied the effect of the collimator angles on the results of…

Medical Physics · Physics 2015-03-13 Yong Ho Kim , Ha Ryung Park , Won Taek Kim , Dong Won Kim , Yongkan Ki , Juhye Lee , Jinsuk Bae , Dahl Park

Purpose: To verify dose delivery and quality assurance of volumetric modulated arc therapy (VMAT) for head and neck cancer. Method: The Imaging and Radiation Oncology Core Houston (IROC-H) head and neck phantom with thermo- luminescent…

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

A central problem in the field of radiation therapy (RT) is how to optimally deliver dose to a patient in a way that fully accounts for anatomical position changes over time. As current RT is a static process, where beam intensities are…

Medical Physics · Physics 2019-09-04 Rodney D. Wiersma , Xinmin Liu

This study evaluates dynamic conformal arc (DCA) therapy as an alternative to volumetric modulated arc therapy (VMAT) for stereotactic body radiation therapy (SBRT) of lung cancer. The rationale for DCA is lower geometric complexity and…

Medical Physics · Physics 2019-05-07 Rasmus Bokrantz , Minna Wedenberg , Peter Sandwall

In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment delivery methods, such as IMRT, VMAT, tomotherapy, LDR/HDR…

Medical Physics · Physics 2018-10-31 Bram L. Gorissen , Jan Unkelbach , Thomas R. Bortfeld

The main approach to smooth Pareto surface navigation for radiation therapy multi-criteria treatment planning involves taking real-time averages of pre-computed treatment plans. In fluence-based treatment planning, fluence maps themselves…

Medical Physics · Physics 2014-02-03 David Craft , David Papp , Jan Unkelbach
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