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Summary: BWA-MEM is a new alignment algorithm for aligning sequence reads or long query sequences against a large reference genome such as human. It automatically chooses between local and end-to-end alignments, supports paired-end reads…

Genomics · Quantitative Biology 2013-05-28 Heng Li

Large Vision-Language Models (LVLMs) have demonstrated remarkable performance across a wide range of multimodal tasks. However, fine-tuning these models for domain-specific applications remains a computationally intensive challenge. This…

Computer Vision and Pattern Recognition · Computer Science 2024-12-16 Chee Ng , Yuen Fung

In this work, we present a methodology and a corresponding code-base for constructing mock integral field spectrograph (IFS) observations of simulated galaxies in a consistent and reproducible way. Such methods are necessary to improve the…

This note is concerned with accurate and computationally efficient approximations of moments of Gaussian random variables passed through sigmoid or softmax mappings. These approximations are semi-analytical (i.e. they involve the numerical…

Machine Learning · Statistics 2017-03-07 Jean Daunizeau

The scalability of a particular visualization approach is limited by the ability for people to discern differences between plots made with different datasets. Ideally, when the data changes, the visualization changes in perceptible ways.…

Human-Computer Interaction · Computer Science 2019-07-29 Rafael Veras , Christopher Collins

We propose a series of methods to represent the evolution of a field of science at different levels: namely micro, meso and macro levels. We use a previously introduced asymmetric measure of paradigmatic proximity between terms that enables…

Other Computer Science · Computer Science 2008-12-18 Jean-Philippe Cointet , David Chavalarias

Plot-based Graphic API recommendation (Plot2API) is an unstudied but meaningful issue, which has several important applications in the context of software engineering and data visualization, such as the plotting guidance of the beginner,…

Software Engineering · Computer Science 2021-04-05 Zeyu Wang , Sheng Huang , Zhongxin Liu , Meng Yan , Xin Xia , Bei Wang , Dan Yang

Large language models (LLMs) have demonstrated remarkable advancements, primarily due to their capabilities in modeling the hidden relationships within text sequences. This innovation presents a unique opportunity in the field of life…

Genomics · Quantitative Biology 2024-12-25 Cong Li , Qingqing Long , Yuanchun Zhou , Meng Xiao

A method for automated quantification of the alignment of one-dimensional nanostructures from microscopy imaging is presented. Nanostructure alignment metrics are formulated and shown to able to rigorously quantify the orientational order…

Instrumentation and Detectors · Physics 2016-08-03 Jianjin Dong , Irene A. Goldthorpe , Nasser Mohieddin Abukhdeir

RNA-sequencing (RNA-seq) has become an exemplar technology in modern biology and clinical applications over the past decade. It has gained immense popularity in the recent years driven by continuous efforts of the bioinformatics community…

Medical imaging and multi-modal clinical settings often face the challange of missing modality in their diagnostic pipelines. Existing imputation methods either lack representational capacity or are computationally expensive. We propose…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Afifa Khaled , Ebrahim Hamid Sumiea

In computational biology, biological entities such as genes or proteins are usually annotated with terms extracted from Gene Ontology (GO). The functional similarity among terms of an ontology is evaluated by using Semantic Similarity…

Computational Engineering, Finance, and Science · Computer Science 2014-12-24 Mario Cannataro , Pietro Hiram Guzzi , Marianna Milano , Pierangelo Veltri

We introduce \emph{Nutri-bullets}, a multi-document summarization task for health and nutrition. First, we present two datasets of food and health summaries from multiple scientific studies. Furthermore, we propose a novel…

Computation and Language · Computer Science 2021-03-23 Darsh J Shah , Lili Yu , Tao Lei , Regina Barzilay

Self-supervised Learning (SSL) has become a powerful paradigm for representation learning without manual annotations. However, most existing frameworks focus on global alignment and struggle to capture the hierarchical, multi-scale lesion…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Abdullah Al Mamun , Miaohua Zhang , David Ahmedt-Aristizabal , Zeeshan Hayder , Mohammad Awrangjeb

Efforts to utilize growing volumes of clinical imaging data to generate tumor evaluations continue to require significant manual data wrangling owing to the data heterogeneity. Here, we propose an artificial intelligence-based solution for…

{\it SimRank} is a classic measure of the similarities of nodes in a graph. Given a node $u$ in graph $G =(V, E)$, a {\em single-source SimRank query} returns the SimRank similarities $s(u, v)$ between node $u$ and each node $v \in V$. This…

Data Structures and Algorithms · Computer Science 2019-05-08 Zhewei Wei , Xiaodong He , Xiaokui Xiao , Sibo Wang , Yu Liu , Xiaoyong Du , Ji-Rong Wen

The typical process for classifying and submitting a newly sequenced virus to the NCBI database involves two steps. First, a BLAST search is performed to determine likely family candidates. That is followed by checking the candidate…

Genomics · Quantitative Biology 2016-03-22 Troy Hernandez , Jie Yang

Visualization onboarding supports users in reading, interpreting, and extracting information from visual data representations. General-purpose onboarding tools and libraries are applicable for explaining a wide range of graphical user…

RNA junctions are important structural elements of RNA molecules. They are formed when three or more helices come together in three-dimensional space. Recent studies have focused on the annotation and prediction of coaxial helical stacking…

Computational Engineering, Finance, and Science · Computer Science 2016-09-08 Lei Hua , Yang Song , Namhee Kim , Christian Laing , Jason T. L. Wang , Tamar Schlick

Computational intensity and sequential nature of estimation techniques for Bayesian methods in statistics and machine learning, combined with their increasing applications for big data analytics, necessitate both the identification of…

Computation · Statistics 2015-03-02 Alireza S. Mahani , Mansour T. A. Sharabiani
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