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The idea is a nanoscale extension of a sporting event called a `color run'. The filament is wrapped with a DNA origami `barrel', which acts as the nanoscale equivalent of a white t-shirt. The DNA t-shirt has dangling ss-DNA `handles' that…

Soft Condensed Matter · Physics 2019-09-16 A. P. Micolich

DNA labeling is a powerful tool in molecular biology and biotechnology that allows for the visualization, detection, and study of DNA at the molecular level. Under this paradigm, a DNA molecule is being labeled by specific k patterns and is…

Information Theory · Computer Science 2024-01-24 Dganit Hanania , Daniella Bar-Lev , Yevgeni Nogin , Yoav Shechtman , Eitan Yaakobi

Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA…

With the continued improvement of sequencing technologies, the prospect of genome-based medicine is now at the forefront of scientific research. To realize this potential, however, we need a revolutionary sequencing method for the…

Biological Physics · Physics 2008-01-03 Michael Zwolak , Massimiliano Di Ventra

We propose generative neural network methods to generate DNA sequences and tune them to have desired properties. We present three approaches: creating synthetic DNA sequences using a generative adversarial network; a DNA-based variant of…

Machine Learning · Computer Science 2017-12-19 Nathan Killoran , Leo J. Lee , Andrew Delong , David Duvenaud , Brendan J. Frey

Rotary motors play key roles in energy transduction, from macroscale windmills to nanoscale turbines such as ATP synthase in cells. Despite our capabilities to construct engines at many scales, developing functional synthetic turbines at…

Origami is an ancient art that continues to yield both artistic and scientific insights to this day. In 2012, Buhler, Butler, de Launey, and Graham extended these ideas even further by developing a mathematical construction inspired by…

Rings and Algebras · Mathematics 2023-06-07 Deveena R. Banerjee , Sara Chari , Adriana Salerno

Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami…

Optics · Physics 2015-06-19 James Cybulski , James Clements , Manu Prakash

Programmable optical neural networks (ONNs) can offer high-throughput and energy-efficient solutions for accelerating artificial intelligence (AI) computing. However, existing ONN architectures, typically based on cascaded unitary…

Optical antennas have been extensively employed to manipulate the photophysical properties of single photon emitters. Coupling between an emitter and a given resonant mode of an optical antenna depends mainly on three parameters: spectral…

The oxDNA model of DNA has been applied widely to systems in biology, biophysics and nanotechnology. It is currently available via two independent open source packages. Here we present a set of clearly-documented exemplar simulations that…

Biomolecules · Quantitative Biology 2022-09-26 Aditya Sengar , Thomas E. Ouldridge , Oliver Henrich , Lorenzo Rovigatti , Petr Sulc

We present Quantum Brush, an open-source digital painting tool that harnesses quantum computing to generate novel artistic expressions. The tool includes four different brushes that translate strokes into unique quantum algorithms, each…

As deep neural network (DNN) models grow ever-larger, they can achieve higher accuracy and solve more complex problems. This trend has been enabled by an increase in available compute power; however, efforts to continue to scale electronic…

Emerging Technologies · Computer Science 2020-06-25 Liane Bernstein , Alexander Sludds , Ryan Hamerly , Vivienne Sze , Joel Emer , Dirk Englund

The diversity and heterogeneity of biomarkers has made the development of general methods for single-step quantification of analytes difficult. For individual biomarkers, electrochemical methods that detect a conformational change in an…

I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap.

Biological Physics · Physics 2008-10-20 Henk W. Ch. Postma

Based on modern single molecule techniques, we devise a number of possible experimental setups to probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtain information on the DNA-sequence. Similarly, DNA…

Soft Condensed Matter · Physics 2007-05-23 Ralf Metzler , Tobias Ambjoernsson

The current technological development allows us to carry out tasks that some time ago were unthinkable if not impossible, digital image processing has been one of the major constants of development today, taking into account that its…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Benjamin Andres Huerfano Zapata

The study of DNA charge dynamics is a highly interdisciplinary field that bridges physics, chemistry, biology, and medicine, and plays a critical role in processes such as DNA damage detection, protein-DNA interactions, and DNA-based…

Biomolecules · Quantitative Biology 2025-02-12 Dennis Herb , Marco Trenti , Marilena Mantela , Constantinos Simserides , Joachim Ankerhold , Mirko Rossini

Optical nanoantennas are structures designed to manipulate light-matter interactions at the nanoscale by interfacing propagating light with localized optical fields. In recent years, a plethora of devices have been realized that are able to…

Molecular fingerprints are significant cheminformatics tools to map molecules into vectorial space according to their characteristics in diverse functional groups, atom sequences, and other topological structures. In this paper, we set out…

Applications · Statistics 2023-01-05 Xue Liu , Qian Cheng , Dan Sun , Xing Li , Wei Wei , Zhiming Zheng