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We report a theoretical/computational approach for modeling the current-voltage characteristics of sensing proteins. The modeling is applied to a couple of transmembrane proteins, bacteriorhodopsin and proteorhodopsin, sensitive to visible…

Biological Physics · Physics 2014-02-04 E Alfinito , J Pousset , L Reggiani

We report on charge transport and current fluctuations in a single bacteriorhodpsin protein in a wide range of applied voltages covering direct and injection tunnelling regimes. The satisfactory agreement between theory and available…

Mesoscale and Nanoscale Physics · Physics 2011-02-17 J. -F. Millithaler , E. Alfinito , L. Reggiani

When moving from native to light activated bacteriorhodopsin, modification of charge transport consisting of an increase of conductance is correlated to the protein conformational change. A theoretical model based on a map of the protein…

Quantitative Methods · Quantitative Biology 2011-02-17 Eleonora Alfinito , Lino Reggiani

The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the…

Biological Physics · Physics 2015-06-16 E Alfinito , J Pousset , L Reggiani , K Lee

Recently, a growing interest has been addressed to the electrical properties of bacteriorhodopsin (bR), a protein belonging to the transmembrane protein family. To take into account the structure-dependent nature of the current, in a…

Soft Condensed Matter · Physics 2015-03-06 E. Alfinito , L. Reggiani

We investigate a particular phase transition between two different tunneling regimes, direct and injection (Fowler-Nordheim), experimentally observed in the current-voltage characteristics of the light receptor bacteriorhodopsin (bR). Here,…

Statistical Mechanics · Physics 2012-04-17 E. Alfinito , J. F. Millithaler , L. Reggiani

We demonstrate a technique based on noise measurements which can be utilized to study dynamical processes in protein assembly. Direct visualization of dynamics in membrane protein system such as bacteriorhodopsin (bR) upon photostimulation…

Chemical Physics · Physics 2015-05-27 Anshuman. J. Das , Sabyasachi Mukhopadhyay , K. S. Narayan

We have investigated the transport and noise properties of submicron YBCO bicrystal grain-boundary junctions prepared using electron beam lithography. The junctions show an increased conductance for low voltages reminiscent of Josephson…

Superconductivity · Physics 2009-10-31 F. Herbstritt , T. Kemen , L. Alff , A. Marx , R. Gross

The electrical properties of a set of seven-helix transmembrane proteins, whose space arrangement (3D structure) is known, are investigated by using regular arrays of the amino acids. These structures, specifically cubes, have topological…

Soft Condensed Matter · Physics 2016-06-02 Eleonora Alfinito , Lino Reggiani

The distribution of resistance fluctuations of conducting thin films with granular structure near electrical breakdown is studied by numerical simulations. The film is modeled as a resistor network in a steady state determined by the…

Statistical Mechanics · Physics 2009-11-10 C. Pennetta , E. Alfinito , L. Reggiani , S. Ruffo

The remarkable ability of natural proteins to conduct electricity in the dry state over long distances remains largely inexplicable despite intensive research. In some cases, a (weakly) exponential length-attenuation, as in off-resonant…

We study the resistance fluctuation distribution of a thin film near electrical breakdown. The film is modeled as a stationary resistor networkunder biased percolation. Depending on the value of the external current,on the system sizes and…

Condensed Matter · Physics 2009-11-10 C. Pennetta , E. Alfinito , L. Reggiani , S. Ruffo

Current voltage (I-V) characteristics in proteins can be sensitive to conformational change induced by an external stimulus (photon, odour, etc.). This sensitivity can be used in medical and industrial applications besides shedding new…

Soft Condensed Matter · Physics 2015-05-28 Eleonora Alfinito , Jean-Francois Millithaler , Lino Reggiani

A study of the conductance noise in a two-dimensional electron system (2DES) in Si at low temperatures (T) reveals the onset of large, non-Gaussian noise after cooling from an equilibrium state at a high T with a fixed carrier density n_s.…

Strongly Correlated Electrons · Physics 2012-10-31 Ping V. Lin , Xiaoyan Shi , J. Jaroszynski , Dragana Popović

We report on fluctuations in the electron system, Cooper pairs and quasiparticles, of a superconducting aluminium film. The superconductor is exposed to pair-breaking photons (1.54 THz), which are coupled through an antenna. The change in…

Superconductivity · Physics 2014-02-06 P. J. de Visser , J. J. A. Baselmans , J. Bueno , N. Llombart , T. M. Klapwijk

We study the distribution of resistance fluctuations of conducting thin films with different levels of internal disorder. The film is modeled as a resistor network in a steady state determined by the competition between two biased…

Disordered Systems and Neural Networks · Physics 2009-11-10 C. Pennetta , E. Alfinito , L. Reggiani , S. Ruffo

Multicellular cable bacteria display an exceptional form of biological conduction, channeling electrical currents across centimeter distances through a regular network of protein fibers embedded in the cell envelope. The fiber conductivity…

Recent experiments using fluorescence spectroscopy have been able to probe the dynamics of conformational fluctuations in proteins. The fluctuations are Gaussian but do not decay exponentially, and are therefore, non-Markovian. We present a…

Statistical Mechanics · Physics 2008-10-14 Arti Dua , R. Adhikari

We present results of conductance-noise experiments on disordered films of crystalline indium oxide with lateral dimensions 2microns to 1mm. The power-spectrum of the noise has the usual 1/f form, and its magnitude increases with inverse…

Disordered Systems and Neural Networks · Physics 2009-11-11 V. Orlyanchik , V. I. Kozub , Z. Ovadyahu

We simulate the electrical properties of a device realized by a G protein coupled receptor (GPCR), embedded in its membrane and in contact with two metallic electrodes through which an external voltage is applied. To this purpose, recently,…

Quantitative Methods · Quantitative Biology 2009-11-11 C. Pennetta , V. Akimov , E. Alfinito , L. Reggiani , G. Gomila , G. Ferrari , L. Fumagalli , M. Sampietro
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