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Pathway enrichment analysis has become a key tool for biomedical researchers to gain insight into the underlying biology of differentially expressed genes, proteins and metabolites. It reduces complexity and provides a system-level view of…

Methodology · Statistics 2016-06-24 Jing Ma , Ali Shojaie , George Michailidis

Complex network states are characterized by the interplay between system's structure and dynamics. One way to represent such states is by means of network density matrices, whose von Neumann entropy characterizes the number of distinct…

Physics and Society · Physics 2022-12-06 Arsham Ghavasieh , Manlio De Domenico

Centrality metrics aim to identify the most relevant nodes in a network. In literature, a broad set of metrics exists, either measuring local or global centrality characteristics. Nevertheless, when networks exhibit a high spectral gap, the…

Physics and Society · Physics 2025-10-20 Lorenzo Costantini , Carla Sciarra , Luca Ridolfi , Francesco Laio

The concept of entropy rate for a dynamical process on a graph is introduced. We study diffusion processes where the node degrees are used as a local information by the random walkers. We describe analitically and numerically how the degree…

Statistical Mechanics · Physics 2009-11-13 Jesus Gomez-Gardenes , Vito Latora

Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…

Molecular Networks · Quantitative Biology 2018-06-29 Marieke Lydia Kuijjer , Matthew Tung , GuoCheng Yuan , John Quackenbush , Kimberly Glass

We consider a Gaussian statistical model whose parameter space is given by the variances of random variables. Underlying this model we identify networks by interpreting random variables as sitting on vertices and their correlations as…

Mathematical Physics · Physics 2015-06-17 Domenico Felice , Stefano Mancini , Marco Pettini

Inferring topological characteristics of complex networks from observed data is critical to understand the dynamical behavior of networked systems, ranging from the Internet and the World Wide Web to biological networks and social networks.…

Multiagent Systems · Computer Science 2020-05-13 Chunheng Jiang , Jianxi Gao , Malik Magdon-Ismail

To quantify the complexity of a system, entropy-based methods have received considerable critical attentions in real-world data analysis. Among numerous entropy algorithms, amplitude-based formulas, represented by Sample Entropy, suffer…

Signal Processing · Electrical Eng. & Systems 2022-01-12 Hongjian Xiao , Danilo P. Mandic

We study the dynamics of gene activities in relatively small size biological networks (up to a few tens of nodes), e.g. the activities of cell-cycle proteins during the mitotic cell-cycle progression. Using the framework of deterministic…

Molecular Networks · Quantitative Biology 2009-11-13 Gautier Stoll , Jacques Rougemont , Felix Naef

This paper is Part II of a two-part series devoting to the study of systematic measures in a complex bio-network modeled by a system of ordinary differential equations. In this part, we quantify several systematic measures of a biological…

Probability · Mathematics 2016-06-13 Yao Li , Yingfei Yi

Maximum entropy principle (MEP) offers an effective and unbiased approach to inferring unknown probability distributions when faced with incomplete information, while neural networks provide the flexibility to learn complex distributions…

Machine Learning · Statistics 2024-12-04 Wuyue Yang , Liangrong Peng , Guojie Li , Liu Hong

Properties of networks are often characterized in terms of features such as node degree distributions, average path lengths, diameters, or clustering coefficients. Here, we study shortest path length distributions. On the one hand, average…

Social and Information Networks · Computer Science 2015-01-20 Christian Bauckhage , Kristian Kersting , Fabian Hadiji

The analysis of temporal networks heavily depends on the analysis of time-respecting paths. However, before being able to model and analyze the time-respecting paths, we have to infer the timescales at which the temporal edges influence…

Physics and Society · Physics 2023-01-30 Luka V. Petrović , Anatol Wegner , Ingo Scholtes

A central issue of the science of complex systems is the quantitative characterization of complexity. In the present work we address this issue by resorting to information geometry. Actually we propose a constructive way to associate to a -…

Mathematical Physics · Physics 2017-12-19 Roberto Franzosi , Domenico Felice , Stefano Mancini , Marco Pettini

This paper introduces a novel framework that combines traditional centrality measures with eigenvalue spectra and diffusion processes for a more comprehensive analysis of complex networks. While centrality measures such as degree,…

Other Computer Science · Computer Science 2025-03-28 Arsh Jha

Complex systems are large collections of entities that organize themselves into non-trivial structures that can be represented by networks. A key emergent property of such systems is robustness against random failures or targeted attacks…

Physics and Society · Physics 2021-06-14 Arsham Ghavasieh , Massimo Stella , Jacob Biamonte , Manlio De Domenico

Entropy is a measure of self-information which is used to quantify losses. Entropy was developed in thermodynamics, but is also used to compare probabilities based on their deviating information content. Corresponding model uncertainty is…

Probability · Mathematics 2018-01-23 Alois Pichler , Ruben Schlotter

Network equilibrium models represent a versatile tool for the analysis of interconnected objects and their relationships. They have been widely employed in both science and engineering to study the behavior of complex systems under various…

Adaptation and Self-Organizing Systems · Physics 2024-10-31 Omar Aloui , David Orden , Nizar Bel Hadj Ali , Landolf Rhode-Barbarigos

The growing study of time series, especially those related to nonlinear systems, has challenged the methodologies to characterize and classify dynamical structures of a signal. Here we conceive a new diagnostic tool for time series based on…

Other Statistics · Statistics 2017-07-05 G. Corso , T. L. Prado , G. Z. dos S. Lima , S. R. Lopes

Network inference approaches are now widely used in biological applications to probe regulatory relationships between molecular components such as genes or proteins. Many methods have been proposed for this setting, but the connections and…

Applications · Statistics 2014-06-03 Chris. J. Oates , Sach Mukherjee