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Autonomous sustained oscillations are ubiquitous in living and nonliving systems. As open systems, far from thermodynamic equilibrium, they defy entropic laws which mandate convergence to stationarity. We present structural conditions on…
Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes. In this paper we analyse…
We have found a way for penetrating the space of the dynamical systems towards systems of arbitrary dimension exhibiting the nonlinear mixing of a large number of oscillation modes through which extraordinarily complex time evolutions…
We study the emergence of symmetric oscillatory behavior in multi-agent systems where each agent incorporates a continuous memory of its past states and past rates of change, modeled by distributed retarded and neutral delays. The…
We consider an ecological model consisting of two species of predators competing for their common prey with explicit interference competition. With a proper rescaling, the model is portrayed as a singularly perturbed system with one-fast…
We study the dynamics of a delayed predator-prey system with Holling type II functional response, focusing on the interplay between time delay and carrying capacity. Using local and global Hopf bifurcation theory, we establish the existence…
We study a system of coupled phase oscillators near a saddle-node on an invariant circle bifurcation and driven by random intrinsic frequencies. Under the variation of control parameters, the system undergoes a phase transition changing the…
The logistic two-gene negative-feedback oscillator is locally asymptotically stable for all biological parameter values, since the trace of the Jacobian is uniformly negative. Real biological oscillators (circadian rhythms, the segmentation…
We study a system of dynamical units, each of which shows excitable or oscillatory behavior, depending on the choice of parameters. When we couple these units with repressive bonds, we can control the duration of collective oscillations for…
In this paper we analyze a generic dynamical system with $\mathbb{D}_2$ constructed via a Cayley graph. We study the Hopf bifurcation and find conditions for obtaining a unique branch of periodic solutions. Our main result comes from…
Real power systems exhibit dynamics that evolve across a wide range of time scales, from very fast to very slow phenomena. Historically, incorporating these wide-ranging dynamics into a single model has been impractical. As a result, power…
Biological oscillators coordinate individual cellular components so that they function coherently and collectively. They are typically composed of multiple feedback loops, and period mismatch is unavoidable in biological implementations. We…
Specific activator and repressor transcription factors which bind to specific regulator DNA sequences, play an important role in gene activity control. Interactions between genes coding such transcription factors should explain the…
We present a simple low-cost electronic circuit that is able to show two different dynamical regimens with oscillations of voltages and with constant values of them. This device is designed as a negative feedback three-node network inspired…
We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout…
In this work we propose a feedback approach to regulate the chaotic behavior of the whole family of the generalized Lorenz system, by designing a nonlinear delayed feedback control. We first study the effect of the delay on the dynamics of…
We study the effects of time delayed linear and nonlinear feedbacks on the dynamics of a single Hopf bifurcation oscillator. Our numerical and analytic investigations reveal a host of complex temporal phenomena such as phase slips,…
Genes are connected in complex networks of interactions where often the product of one gene is a transcription factor that alters the expression of another. Many of these networks are based on a few fundamental motifs leading to switches…
In this paper, dynamical systems theory and bifurcation theory are applied to investi- gate the rich dynamical behaviours observed in three simple disease models. The 2- and 3-dimensional models we investigate have arisen in previous…
A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has…