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Molecular adhesion plays a central role in many biological systems, yet existing methods to quantify adhesive strength often struggle to bridge the gap between single-molecule resolution and biologically relevant environments. Here, we…
In vivo measurement of the mechanical properties of thin-walled soft tissues (e.g., mitral valve, artery and bladder) and in situ mechanical characterization of thin-walled artificial soft biomaterials in service are of great challenge and…
Volume limitations and low yield thresholds of biological fluids have led to widespread use of passive microparticle rheology. The mean-squared-displacement (MSD) statistics of bead position time series (bead paths) are either applied…
Clinical decisions for unruptured intracranial aneurysms depend on detecting growth on follow-up magnetic resonance angiography (MRA). Growth is typically judged from manual 2D diameters on few slices, which vary across clinicians and…
Here we report on the viscosity of eukaryotic living cells as a function of the time, and on the application of stochastic models to analyze its temporal fluctuations. The viscoelastic properties of NIH/3T3 fibroblastic cells are…
Nano-machines circulating inside the human body, collecting data on tissue conditions, represent a vital part of next-generation medical diagnostic systems. However, for these devices to operate effectively, they need to relay not only…
Currently, connectomes (e.g., functional or structural brain graphs) can be estimated in humans at $\approx 1~mm^3$ scale using a combination of diffusion weighted magnetic resonance imaging, functional magnetic resonance imaging and…
A new class of micromechanically motivated chain network models for soft biological tissues is presented. On the microlevel, it is based on the statistics of long chain molecules. A wormlike chain model is applied to capture the behavior of…
In this work, two real-time methods to transport magnetic nanowires confined in giant hybrid vesi-cles upon the application of different strategies are studied. The microscale carriers are either mag-netically guided through the viscous…
Biophysical modeling is the mediator of evaluating the cellular structure of biological tissues using diffusion-weighted MRI. It is however the bottleneck of microstructural MRI. Beyond the complexity of diffusion, the current development…
It is investigated the statistical properties of random walks evolving on real configurations of a crumpled wire rigidly jammed in two dimensions. These crumpled hierarchical structures with complex topology are obtained from a metallic…
The viscosity of lipid bilayer membranes plays an important role in determining the diffusion constant of embedded proteins and the dynamics of membrane deformations, yet it has historically proven very difficult to measure. Here we…
Microscale propulsion is integral to numerous biomedical systems, for example biofilm formation and human reproduction, where the surrounding fluids comprise suspensions of polymers. These polymers endow the fluid with non-Newtonian…
We study the microrheology of nanoparticle shells [Dinsmore et al. Science 298, 1006 (2002)] and viral capsids [Ivanovska et al. PNAS 101, 7600 (2004)] by computing the mechanical response function and thermal fluctuation spectrum of a…
Recent advances in molecular biology and fluorescence microscopy imaging have made possible the inference of the dynamics of single molecules in living cells. Such inference allows to determine the organization and function of the cell. The…
The mid-infrared region is crucial for elucidating the unique biochemical signatures of microorganisms. The MIR resonant structures turned out to facilitate exceptional performance owing to the enhance electric field confinement in the…
Combining experiments with artificial intelligence algorithms, we propose a new machine learning based approach to extract the cellular force distributions from the microscope images. The full process can be divided into three steps. First,…
Analytic results for the conductance of a molecular wire attached to mesoscopic tubule leads are obtained. They permit to study linear transport in presence of low dimensional leads in the whole range of parameters. In particular contact…
Mycelium, a natural and sustainable material, possesses unique electrical, mechanical, and biological properties that make it a promising candidate for biosensor applications. These properties include its ability to conduct electrical…
Magnetic Resonance Elastography (MRE) can characterize biomechanical properties of soft tissue for disease diagnosis and treatment planning. However, complicated wavefields acquired from MRE coupled with noise pose challenges for accurate…