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The tremdendous advances in high-throughput sequencing technologies have made population-scale sequencing as performed in the 1000 Genomes project and the Genome of the Netherlands project possible. Next-generation sequencing has allowed…

Genomics · Quantitative Biology 2013-03-15 Tobias Marschall , Alexander Schönhuth

We propose and analyze a novel framework for learning sparse representations, based on two statistical techniques: kernel smoothing and marginal regression. The proposed approach provides a flexible framework for incorporating feature…

Machine Learning · Statistics 2012-10-04 Krishnakumar Balasubramanian , Kai Yu , Guy Lebanon

We present novel reductions from sample compression schemes in multiclass classification, regression, and adversarially robust learning settings to binary sample compression schemes. Assuming we have a compression scheme for binary classes…

Machine Learning · Computer Science 2025-04-09 Idan Attias , Steve Hanneke , Arvind Ramaswami

The acquisition of labels for supervised learning can be expensive. To improve the sample efficiency of neural network regression, we study active learning methods that adaptively select batches of unlabeled data for labeling. We present a…

Machine Learning · Statistics 2023-08-02 David Holzmüller , Viktor Zaverkin , Johannes Kästner , Ingo Steinwart

The dominant approach to generating from language models subject to some constraint is locally constrained decoding (LCD), incrementally sampling tokens at each time step such that the constraint is never violated. Typically, this is…

A method for encoding information in DNA sequences is described. The method is based on the precision-resolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis…

Information Theory · Computer Science 2020-05-14 Siddharth Jain , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

Today's HPC applications are producing extremely large amounts of data, such that data storage and analysis are becoming more challenging for scientific research. In this work, we design a new error-controlled lossy compression algorithm…

Information Theory · Computer Science 2017-06-14 Dingwen Tao , Sheng Di , Zizhong Chen , Franck Cappello

While dense retrieval models, which embed queries and documents into a shared low-dimensional space, have gained widespread popularity, they were shown to exhibit important theoretical limitations and considerably lag behind traditional…

Information Retrieval · Computer Science 2026-04-09 Adrian Bracher , Svitlana Vakulenko

Ever since deoxyribonucleic acid (DNA) was considered as a next-generation data-storage medium, lots of research efforts have been made to correct errors occurred during the synthesis, storage, and sequencing processes using error…

Information Theory · Computer Science 2023-06-14 Jaeho Jeong , Hosung Park , Hee-Youl Kwak , Jong-Seon No , Hahyeon Jeon , Jeong Wook Lee , Jae-Won Kim

Large language models (LLMs) achieve strong performance but incur high deployment costs, motivating extremely low-bit but lossy quantization. Existing quantization algorithms mainly focus on improving the numerical accuracy of forward…

Computation and Language · Computer Science 2026-05-18 Yuzhuang Xu , Xu Han , Yuxuan Li , Pengzhan Li , Wanxiang Che

Deep learning has made remarkable progress recently, largely due to the availability of large, well-labeled datasets. However, the training on such datasets elevates costs and computational demands. To address this, various techniques like…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhenghao Zhao , Yuzhang Shang , Junyi Wu , Yan Yan

Repository-level code intelligence tasks require large language models (LLMs) to process long, multi-file contexts. Such inputs introduce three challenges: crucial context can be obscured by noise, truncated due to limited windows, and…

Software Engineering · Computer Science 2026-04-16 Jia Feng , Zhanyue Qin , Cuiyun Gao , Ruiqi Wang , Chaozheng Wang , Yingwei Ma , Xiaoyuan Xie

Background: Several sources of noise obfuscate the identification of single nucleotide variation (SNV) in next generation sequencing data. For instance, errors may be introduced during library construction and sequencing steps. In addition,…

Genomics · Quantitative Biology 2015-03-05 Steve Hoffmann , Peter F. Stadler , Korbinian Strimmer

Many applications require data processing to be performed on individual pieces of data which are of finite sizes, e.g., files in cloud storage units and packets in data networks. However, traditional universal compression solutions would…

Information Theory · Computer Science 2012-05-22 Ahmad Beirami , Mohsen Sardari , Faramarz Fekri

The exponential expansion of context windows in LLMs has unlocked capabilities for long-document understanding but introduced severe bottlenecks in inference latency and information utilization. Existing compression methods often suffer…

Computation and Language · Computer Science 2026-03-23 Zhengpei Hu , Kai Li , Dapeng Fu , Chang Zeng , Yue Li , Yuanhao Tang , Jianqiang Huang

Modern language models are trained almost exclusively on token sequences produced by a fixed tokenizer, an external lossless compressor often over UTF-8 byte sequences, thereby coupling the model to that compressor. This work introduces…

Computation and Language · Computer Science 2026-05-15 Lin Zheng , Xinyu Li , Qian Liu , Xiachong Feng , Lingpeng Kong

Neural contextual biasing allows speech recognition models to leverage contextually relevant information, leading to improved transcription accuracy. However, the biasing mechanism is typically based on a cross-attention module between the…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-05 Nikolaos Flemotomos , Roger Hsiao , Pawel Swietojanski , Takaaki Hori , Dogan Can , Xiaodan Zhuang

Composite DNA is a recent novel method to increase the information capacity of DNA-based data storage above the theoretical limit of 2 bits/symbol. In this method, every composite symbol does not store a single DNA nucleotide but a mixture…

Information Theory · Computer Science 2025-01-22 Tuan Thanh Nguyen , Chen Wang , Kui Cai , Yiwei Zhang , Zohar Yakhini

Memorization in large language models poses critical risks for privacy and fairness as these systems scale to billions of parameters. While previous studies established correlations between memorization and factors like token frequency and…

Machine Learning · Computer Science 2025-09-01 Jie Zhang , Qinghua Zhao , Chi-ho Lin , Zhongfeng Kang , Lei Li

Most large language models are fine-tuned using either expensive human-annotated data or GPT-4 generated data which cannot guarantee performance in certain domains. We argue that although the web-crawled data often has formatting errors…

Computation and Language · Computer Science 2024-08-16 Jing Zhou , Chenglin Jiang , Wei Shen , Xiao Zhou , Xiaonan He
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