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The fluid flow and heat transfer problems encountered in industry applications span into different scales and there are different numerical methods for different scales problems. It is not possible to use single scale method to solve…

Computational Engineering, Finance, and Science · Computer Science 2019-08-23 Zheng Li , Mo Yang , Yuwen Zhang

QM (quantum mechenics) and MM (molecular mechenics) coupling methods are widely used in simulations of crystalline defects. In this paper, we construct a residual based a posteriori error indicator for QM/MM coupling approximations. We…

Numerical Analysis · Mathematics 2019-06-26 Huajie Chen , Mingjie Liao , Hao Wang , Yangshuai Wang , Lei Zhang

Understanding the complex behavior of molecular systems is fundamental to fields such as physics, materials science, and biology. Molecular dynamics (MD) simulations are crucial tools for studying atomic-level dynamics. This work focuses on…

Computational Engineering, Finance, and Science · Computer Science 2025-07-16 David Martin , Samuel James Newcome , Markus Mühlhäußer , Manish Kumar Mishra , Fabio Alexander Gratl , Hans-Joachim Bungartz

Biochemical reactions can happen on different time scales and also the abundance of species in these reactions can be very different from each other. Classical approaches, such as deterministic or stochastic approach, fail to account for or…

Quantitative Methods · Quantitative Biology 2014-09-16 Arnab Ganguly , Derya Altintan , Heinz Koeppl

The stochastic dynamics of biochemical reaction networks can be accurately described by discrete-state Markov processes where each chemical reaction corresponds to a state transition of the process. Due to the largeness problem of the state…

Numerical Analysis · Mathematics 2015-10-01 Alexander Andreychenko , Linar Mikeev , Verena Wolf

This paper introduces a new method for performing field transfer operations in black-box coupling, when source discretization information is not available. This approach uses a stochastic approximation of the Galerkin projection which leads…

Computational Engineering, Finance, and Science · Computer Science 2026-03-03 Abhiyan Paudel , Cameron W. Smith , Jacob S. Merson

We present a mean-field approach to simulating merging processes of two spherical collisionless stellar systems. This approach is realized with a self-consistent field (SCF) method in which the full spatial dependence of the density and…

Instrumentation and Methods for Astrophysics · Physics 2019-04-17 Shunsuke Hozumi , Masaki Iwasawa , Keigo Nitadori

Heterogeneous multiscale methods (HMM) combine molecular accuracy of particle-based simulations with the computational efficiency of continuum descriptions to model flow in soft matter liquids. In these schemes, molecular simulations…

There exist several methods for simulating biological and physical systems as represented by chemical reaction networks. Systems with low numbers of particles are frequently modelled as discrete-state Markov jump processes and are typically…

Quantitative Methods · Quantitative Biology 2022-10-24 Joshua C. Kynaston , Christian A Yates , Anna Hekkink , Chris Guiver

The Direct Simulation Monte Carlo (DSMC) method is widely employed for simulating rarefied nonequilibrium gas flows. With advances in aerospace engineering and micro/nano-scale technologies, gas flows exhibit the coexistence of rarefied and…

Computational Physics · Physics 2025-07-01 Hao Jin , Sha Liu , Sirui Yang , Junzhe Cao , Congshan Zhuo , Chengwen Zhong

Stochastic, spatial reaction-diffusion simulations have been widely used in systems biology and computational neuroscience. However, the increasing scale and complexity of simulated models and morphologies have exceeded the capacity of any…

Quantitative Methods · Quantitative Biology 2016-10-10 Weiliang Chen , Erik De Schutter

Markov Chain Monte Carlo (MCMC) methods such as Gibbs sampling are finding widespread use in applied statistics and machine learning. These often lead to difficult computational problems, which are increasingly being solved on parallel and…

Machine Learning · Statistics 2018-06-05 Alexander Terenin , Eric P. Xing

We take up the challenge of designing realistic computational models of large interacting cell populations. The goal is essentially to bring Gillespie's celebrated stochastic methodology to the level of an interacting population of cells.…

Computational Engineering, Finance, and Science · Computer Science 2018-10-26 Stefan Engblom

The efficient and accurate simulation of material systems with defects using atomistic- to-continuum (a/c) coupling methods is a topic of considerable interest in the field of computational materials science. To achieve the desired balance…

Numerical Analysis · Mathematics 2023-09-01 Yangshuai Wang

Stochastic chemical systems with diffusion are modeled with a reaction-diffusion master equation. On a macroscopic level, the governing equation is a reaction-diffusion equation for the averages of the chemical species. On a mesoscopic…

Numerical Analysis · Mathematics 2009-03-06 Stefan Engblom , Lars Ferm , Andreas Hellander , Per Lötstedt

While exact and approximate Riemann solvers are widely used, they exhibit two fundamental limitations: 1) Fail to represent continuous entropy transport processes, resulting in thermodynamic incompatibility that limits their applicability…

Numerical Analysis · Mathematics 2026-01-26 Zhixin Huo

Subdiffusion has been proposed as an explanation of various kinetic phenomena inside living cells. In order to fascilitate large-scale computational studies of subdiffusive chemical processes, we extend a recently suggested mesoscopic model…

Analysis of PDEs · Mathematics 2018-02-19 Emilie Blanc , Stefan Engblom , Andreas Hellander , Per Lötstedt

We apply the cell merging method to a model shallow water problem with a permeable boundary. We use a cut cell approach which is more easily and systematically scalable with different shapes of boundaries. The novel cell merging method…

Numerical Analysis · Mathematics 2021-12-20 Chanyang Ryoo , Kyle Mandli

Simulation based inference has seen increasing interest in the past few years as a promising approach to model the non linear scales of galaxy clustering. The common approach using Gaussian process is to train an emulator over the…

Cosmology and Nongalactic Astrophysics · Physics 2023-11-20 Tyann Dumerchat , Julian Bautista

This study concerns with singularly perturbed systems of second-order reaction-diffusion equations in ODE's. To handle this type of problems, a numerical-asymptotic hybrid method is employed. In this hybrid method, an efficient asymptotic…

Numerical Analysis · Mathematics 2018-08-15 Suleyman Cengizci , Natesan Srinivasan , M. Tarik Atay