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We present a microstructure imaging technique for estimating compartment-specific T2 and T2* simultaneously in the human brain. Microstructure imaging with diffusion MRI (dMRI) has enabled the modelling of intra-neurite and extra-neurite…

Medical Physics · Physics 2024-08-21 Ting Gong , Merlin J. Fair , Kawin Setsompop , Hui Zhang

In vivo cardiac diffusion tensor imaging (cDTI) is a promising Magnetic Resonance Imaging (MRI) technique for evaluating the micro-structure of myocardial tissue in the living heart, providing insights into cardiac function and enabling the…

The goal of diffusion-weighted magnetic resonance imaging (DWI) is to infer the structural connectivity of an individual subject's brain in vivo. To statistically study the variability and differences between normal and abnormal brain…

Neurons and Cognition · Quantitative Biology 2023-03-06 Haocheng Dai , Martin Bauer , P. Thomas Fletcher , Sarang Joshi

Let $v$ be a vector field in a bounded open set $G\subset {\mathbb {R}}^d$. Suppose that $v$ is observed with a random noise at random points $X_i, i=1,...,n,$ that are independent and uniformly distributed in $G.$ The problem is to…

Statistics Theory · Mathematics 2009-09-29 Vladimir Koltchinskii , Lyudmila Sakhanenko , Songhe Cai

Brain activation mapping using functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) contrast has been conventionally focused on probing gray matter, the BOLD contrast in white matter having been generally disregarded.…

Signal Processing · Electrical Eng. & Systems 2019-10-25 David Abramian , Martin Larsson , Anders Eklund , Hamid Behjat

Diffusion Magnetic Resonance Imaging (dMRI) is a non-invasive tool for watching the microstructure of fibrous nerve and muscle tissue. From dMRI, it is possible to estimate 2-rank diffusion tensors imaging (DTI) fields, that are widely used…

Computer Vision and Pattern Recognition · Computer Science 2016-06-28 Hernan Dario Vargas Cardona , Mauricio A. Alvarez , Alvaro A. Orozco

This paper presents a new approach for relatively accurate brain region of interest (ROI) detection from dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) images of a human head with abnormal brain anatomy. Such images…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Svitlana Alkhimova

Diffusion-weighted MRI (DW-MRI) is used to quantitatively characterize the microscopic structure of soft tissue due to the anisotropic diffusion of water in muscle. Applications such as fiber tractography or modeling of tumor spread in soft…

Medical Physics · Physics 2024-06-07 Nadya Shusharina , Xiaofeng Liu , Evangelia Kaza , Miranda Lam , Stephan Maier , Jonghye Woo

Diffusion MRI (dMRI) provides the ability to reconstruct neuronal fibers in the brain, $\textit{in vivo}$, by measuring water diffusion along angular gradient directions in q-space. High angular resolution diffusion imaging (HARDI) can…

Machine Learning · Statistics 2018-05-30 Evan Schwab , René Vidal , Nicolas Charon

In-vivo examination of the physical connectivity of axonal projections through the white matter of the human brain is made possible by diffusion weighted magnetic resonance imaging (dMRI) Analysis of dMRI commonly considers derived scalar…

Image and Video Processing · Electrical Eng. & Systems 2019-12-03 Haraldur T. Hallgrimsson , Richika Sharan , Scott T. Grafton , Ambuj K. Singh

Diffusion MRI (dMRI) is the primary imaging modality used to study brain microstructure in vivo. Reliable and computationally efficient parameter inference for common dMRI biophysical models is a challenging inverse problem, due to factors…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 William Consagra , Lipeng Ning , Yogesh Rathi

In this paper, we propose a method for denoising diffusion-weighted images (DWI) of the brain using a convolutional neural network trained on realistic, synthetic MR data. We compare our results to averaging of repeated scans, a widespread…

Image and Video Processing · Electrical Eng. & Systems 2022-06-02 Jakub Jurek , Andrzej Materka , Kamil Ludwisiak , Agata Majos , Kamil Gorczewski , Kamil Cepuch , Agata Zawadzka

Diffusion Magnetic Resonance Imaging (MRI) exploits the anisotropic diffusion of water molecules in the brain to enable the estimation of the brain's anatomical fiber tracts at a relatively high resolution. In particular, tractographic…

Computational Engineering, Finance, and Science · Computer Science 2016-09-14 Yu Jin , Joseph F. JaJa , Rong Chen , Edward H. Herskovits

Three-dimensional microscopy is often limited by anisotropic spatial resolution, resulting in lower axial resolution than lateral resolution. Current State-of-The-Art (SoTA) isotropic reconstruction methods utilizing deep neural networks…

Image and Video Processing · Electrical Eng. & Systems 2023-06-22 Mingjie Pan , Yulu Gan , Fangxu Zhou , Jiaming Liu , Aimin Wang , Shanghang Zhang , Dawei Li

Background: Diffusion tensor imaging (DTI) has been used to characterize forearm muscle architecture. Since only uniform sampling is performed for seed points rather than fiber tracts, the tracts may be unevenly distributed in the muscle…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Yang Li , Shihan Ma , Jiamin Zhao , Qing Li , Xinjun Sheng

The purpose of this study is to present and compare three denoising diffusion probabilistic models (DDPMs) that generate 3D $T_1$-weighted MRI human brain images. Three DDPMs were trained using 80,675 image volumes from 42,406 subjects…

Image and Video Processing · Electrical Eng. & Systems 2025-11-03 Samuel W. Remedios , Aaron Carass , Jerry L. Prince , Blake E. Dewey

Diffusion MRI is a non-invasive, in-vivo biomedical imaging method for mapping tissue microstructure. Applications include structural connectivity imaging of the human brain and detecting microstructural neural changes. However, acquiring…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Amir Sadikov , Xinlei Pan , Hannah Choi , Lanya T. Cai , Pratik Mukherjee

We suggest to utilize the rich information content about microstructural tissue properties entangled in asymmetric balanced steady-state free precession (bSSFP) profiles to estimate multiple diffusion metrics simultaneously by neural…

In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in the peritumoral region, the area where biopsy…

Quantitative Methods · Quantitative Biology 2022-09-01 Zahra Riahi Samani , Drew Parker , Hamed Akbari , Spyridon Bakas , Ronald L. Wolf , Steven Brem , Ragini Verma

We propose Microscopic Propagator Imaging (MPI) as a novel method to retrieve the indices of the microscopic propagator which is the probability density function of water displacements due to diffusion within the nervous tissue…

Neurons and Cognition · Quantitative Biology 2025-03-03 Tommaso Zajac , Gloria Menegaz , Marco Pizzolato
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