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Motivated by recent work on studying massive imaging data in various neuroimaging studies, we propose a novel spatially varying coefficient model (SVCM) to spatially model the varying association between imaging measures in a…

Methodology · Statistics 2014-12-01 Hongtu Zhu , Jianqing Fan , Linglong Kong

The brain's white matter (WM) undergoes developmental and degenerative processes during the human lifespan. To investigate the relationship between WM anatomical regions and age, we study diffusion magnetic resonance imaging tractography…

Neurons and Cognition · Quantitative Biology 2023-07-06 Yuxiang Wei , Tengfei Xue , Yogesh Rathi , Nikos Makris , Fan Zhang , Lauren J. O'Donnell

Various metrics for comparing diffusion tensors have been recently proposed in the literature. We consider a broad family of metrics which is indexed by a single power parameter. A likelihood-based procedure is developed for choosing the…

Methodology · Statistics 2010-09-17 Ian L. Dryden , Xavier Pennec , Jean-Marc Peyrat

Tensor regression methods have been widely used to predict a scalar response from covariates in the form of a multiway array. In many applications, the regions of tensor covariates used for prediction are often spatially connected with…

Methodology · Statistics 2024-04-02 Shuoli Chen , Kejun He , Shiyuan He , Yang Ni , Raymond K. W. Wong

Deep learning approaches for diffusion MRI have so far focused primarily on voxel-based segmentation of lesions or white-matter fiber tracts. A drawback of representing tracts as volumetric labels, rather than sets of streamlines, is that…

Image and Video Processing · Electrical Eng. & Systems 2020-09-10 Christian Ewert , David Kügler , Anastasia Yendiki , Martin Reuter

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Motivated by population studies of Diffusion Tensor Imaging, the paper investigates the use of mean-based and dispersion-based permutation tests to define and compute the significance of a statistical test for data taking values on…

Statistics Theory · Mathematics 2013-05-07 Anne Collard , Christophe Phillips , Rodolphe Sepulchre

We extend the varying coefficient functional linear model to the nonlinear model and propose a varying coefficient functional additive model. The proposed method can represent the relationship between functional predictors and a scalar…

Methodology · Statistics 2020-05-27 Hidetoshi Matsui

In this work, we propose a novel framework for estimating the dimension of the data manifold using a trained diffusion model. A diffusion model approximates the score function i.e. the gradient of the log density of a noise-corrupted…

Machine Learning · Computer Science 2023-05-26 Jan Stanczuk , Georgios Batzolis , Teo Deveney , Carola-Bibiane Schönlieb

Geostatistical modeling for continuous point-referenced data has been extensively applied to neuroimaging because it produces efficient and valid statistical inference. However, diffusion tensor imaging (DTI), a neuroimaging characterizing…

Due to recent technological advances, large brain imaging data sets can now be collected. Such data are highly complex so extraction of meaningful information from them remains challenging. Thus, there is an urgent need for statistical…

Applications · Statistics 2021-06-30 Seungyong Hwang , Thomas C. M. Lee , Debashis Paul , Jie Peng

High angular resolution diffusion imaging data is the observed characteristic function for the local diffusion of water molecules in tissue. This data is used to infer structural information in brain imaging. Nonparametric scalar measures…

Applications · Statistics 2011-08-17 Sofia C. Olhede , Brandon Whitcher

Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…

Quantitative Methods · Quantitative Biology 2024-03-05 Richard G. Carson , Alexander Leemans

Diffusion magnetic resonance imaging, a non-invasive tool to infer white matter fiber connections, produces a large number of streamlines containing a wealth of information on structural connectivity. The size of these tractography outputs…

Computer Vision and Pattern Recognition · Computer Science 2018-04-17 Kuldeep Kumar , Kaleem Siddiqi , Christian Desrosiers

We present a novel framework for the probabilistic modelling of random fourth order material tensor fields, with a focus on tensors that are physically symmetric and positive definite (SPD), of which the elasticity tensor is a prime…

Computational Engineering, Finance, and Science · Computer Science 2025-04-03 Sharana Kumar Shivanand , Bojana Rosić , Hermann G. Matthies

Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging,…

Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific…

Quantitative Methods · Quantitative Biology 2019-06-21 Samuel St-Jean , Maxime Chamberland , Max A. Viergever , Alexander Leemans

Purpose: Diffusion-weighted steady-state free precession (DW-SSFP) is shown to provide a means to probe non-Gaussian diffusion through manipulation of the flip angle. A framework is presented to define an effective b-value in DW-SSFP.…

Medical Physics · Physics 2019-11-05 Benjamin C. Tendler , Sean Foxley , Michiel Cottaar , Saad Jbabdi , Karla Miller

Butterfly tumors are a distinct class of gliomas that span the corpus callosum, producing a characteristic butterfly-shaped appearance on MRI. The distinctive growth pattern of these tumors highlights how white matter fibers and structural…

Statistical inference on large-dimensional tensor data has been extensively studied in the literature and widely used in economics, biology, machine learning, and other fields, but how to generate a structured tensor with a target…

Methodology · Statistics 2026-04-02 Jianhua Guo , Xinbing Kong , Zeyu Li , Junfan Mao