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The study reported here concerns a phenomenon, discovered and extensively investigated by Sorin Comorosan, wherein enzyme initial reaction rates are enhanced as a consequence of incorporation of solutions derived from previously irradiated…

Biomolecules · Quantitative Biology 2013-04-29 George E. Bass , James E. Chenevey

Initial reaction rate data for lactic dehydrogenase / pyruvate, lactic dehydrogenase / lactate and malic dehydrogenase / malate enzyme reactions were analyzed to obtain activation free energy changes of -329, -195 and -221 cal/mole,…

Subcellular Processes · Quantitative Biology 2007-06-12 George E. Bass , Bernd Meibohm , James T. Dalton , Robert Sayre

In 1968, Sorin Comorosan first reported a phenomenon wherein irradiation of the substrate of an enzyme reaction, in the crystalline state, for a specific number of seconds could lead to an enhanced aqueous solution reaction rate for the…

Subcellular Processes · Quantitative Biology 2007-06-13 George E. Bass

Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to…

Subcellular Processes · Quantitative Biology 2011-11-09 Joshua Downer , Joel R. Sevinsky , Natalie G. Ahn , Katheryn A. Resing , M. D. Betterton

The objective of this study was to characterize hemodynamic changes during trans-vascular stimulation of the renal nerve and their dependence on stimulation parameters. We employed a stimulation catheter inserted in the right renal artery…

Quantitative Methods · Quantitative Biology 2024-06-06 Filippo Agnesi , Lucia Carlucci , Gia Burjanadze , Fabio Bernini , Khatia Gabisonia , John W Osborn , Silvestro Micera , Fabio A. Recchia

Photoexcitation by ultrashort laser pulses plays a crucial role in controlling reaction pathways, creating nonequilibrium material properties, and offering a microscopic view of complex dynamics at the molecular level. The photo response…

The activation of a specific immune response takes place in the lymphoid organs such as the spleen. We present here a simplified model of the proliferation of specific immune cells in the form of a single delay equation. We show that the…

Dynamical Systems · Mathematics 2010-07-02 Angela Gallegos , Ami Radunskaya

Low-dose ionizing radiation may induce far-reaching consequences in human, especially regarding intrauterine development. Many studies have documented that the risks of in utero irradiation remain controversial and no effect is reported at…

It previously has been discovered that visible light irradiation of crystalline substrates can lead to enhancement of subsequent enzymatic reaction rates as sharply peaked oscillatory functions of irradiation time. The particular activating…

Biomolecules · Quantitative Biology 2007-06-22 George E. Bass

This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and…

Tissues and Organs · Quantitative Biology 2023-01-16 Kristen A. Windoloski , Elisabeth O. Bansgaard , Atanaska Dobreva , Johnny T. Ottesen , Mette S. Olufsen

Rate of a reaction is enhanced by increase in temperature, partial pressure or the concentration of reactants, and/or via use of a catalyst or an enzyme. Whereas the former increases the probability of collision rate between different…

Soft Condensed Matter · Physics 2023-02-24 Nitish Singh , Animangsu Ghatak

Purpose: Our aim was to elucidate the critical factors responsible for inducing the FLASH effect, focusing on the role of free radicals through simulation and experimental approaches. Methods and Materials: The whole abdomen of C57BL/6 mice…

Some biochemical and metabolic characteristics of bovine sperm cells irradiated with low-level laser were probed and correlated to the irradiation parameters. Bovine spermatozoa were exposed to spatially filtered light from a He-Ne laser…

Non-resonant fusion cross-sections significantly higher than corresponding theoretical predictions are observed in low-energy experiments with deuterated matrix target. Models based on thermal effects, electron screening, or quantum-effect…

Nuclear Theory · Physics 2018-02-14 M. Coraddu , M. Lissia , P. Quarati

Nuclear reactions induced by a strong zeptosecond laser pulse are studied theoretically in the quasiadiabatic regime where the photon absorption rate is comparable to the nuclear equilibration rate. We find that multiple photon absorption…

Nuclear Theory · Physics 2014-05-28 A. Pálffy , H. A. Weidenmüller

We study the spontaneous de-excitation and excitation of accelerated atoms on arbitrary stationary trajectories (``generalized Unruh effect''). We consider the effects of vacuum fluctuations and radiation reaction separately. We show that…

Quantum Physics · Physics 2009-10-28 Juergen Audretsch , Rainer Mueller , Markus Holzmann

Above-bandgap femtosecond optical excitation of a ferroelectric/dielectric BaTiO3/CaTiO3 superlattice leads to structural responses that are a consequence of the screening of the strong electrostatic coupling between the component layers.…

Background: An increased QT/RR slope is hypothesized to be predictive of sudden cardiac death after myocardial infarction. Previous studies have shown that beta-adrenergic stimulation increases QT/RR slope, but the effects of…

Tissues and Organs · Quantitative Biology 2009-06-30 Tomofumi Kimotsuki , Noriko Niwa , Martin N. Hicks , Michael Dunne , Stuart M. Cobbe , Mari A. Watanabe

Resonant Inelastic X-Ray Scattering (RIXS) spectra of hematite were measured at the Fe L3-edge for heteroepitaxial thin films which were undoped and doped with 1% Ti, Sn or Zn, in the energy loss range in excess of 1 eV to study electronic…

Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules. Such activated dendritic…

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