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Related papers: On the possibility of electronic DNA nanobiochips

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Charge transfer can take place along double helical DNA over distances as long as 30 nanometers. However, given the active role of the thermal environment surrounding charge carriers in DNA, physical mechanisms driving the transfer process…

Mesoscale and Nanoscale Physics · Physics 2020-12-04 Roman Korol , Dvira Segal

We report theoretical studies of charge transport in single-stranded DNA in the direction perpendicular to the backbone axis. We find that, if the electrodes which sandwich the DNA have the appropriate spatial width, each nucleotide carries…

Other Condensed Matter · Physics 2010-11-03 Michael Zwolak , Massimiliano Di Ventra

Rapid and cost-effective DNA sequencing at the single nucleotide level might be achieved by measuring a transverse electronic current as single-stranded DNA is pulled through a nano-sized pore. In order to enhance the electronic coupling…

Mesoscale and Nanoscale Physics · Physics 2015-05-30 X. Chen , I. Rungger , C. D. Pemmaraju , U. Schwingenschlogl , S. Sanvito

We propose a DNA sequencing scheme based on silicene nanopores. Using first principles theory, we compute the electrical properties of such pores in the absence and presence of nucleobases. Within a two-terminal geometry, we analyze the…

Quantitative Methods · Quantitative Biology 2014-05-16 Hatef Sadeghi , S. Bailey , Colin J. Lambert

The influence of decoherence and bonding on the linear conductance of single double-stranded DNA molecules is examined by fitting a phenomenological statistical model developed recently (EPJB {\bf 68}, 237 (2009)) to experimental results.…

Soft Condensed Matter · Physics 2010-09-30 M. Zilly , O. Ujsaghy , D. E. Wolf

The dielectrophoresis method for trapping and attaching nanoscale double-stranded DNA between nanoelectrodes was developed. The method gives a high yield of trapping single or a few molecules only which enables transport measurements at the…

Soft Condensed Matter · Physics 2007-05-23 S. Tuukkanen , A. Kuzyk , J. J. Toppari , V. P. Hytonen , T. Ihalainen , P. Torma

Recently solid state nanopores nanogaps have generated a lot of interest in ultrafast DNA sequencing. However, there are challenges to slow down the DNA translocation process to achieve a single nucleobase resolution. A series of…

Applied Physics · Physics 2020-04-24 Rameshwar L. Kumawat , Priyanka Garg , Gargee Bhattacharyya , Biswarup Pathak

DNA nanotechnology uses predictable interactions of nucleic acids to precisely engineer complex nanostructures. Characterizing these self-assembled structures at the single-structure level is crucial for validating their design and…

Biological Physics · Physics 2025-10-21 Wangwei Dong , Zezhou Liu , Ruiyao Liu , Deborah Kuchnir Fygenson , Walter Reisner

In this work, we model the zero-bias conductance for the four different DNA strands that were used in conductance measurement experiment [A. K. Mahapatro, K. J. Jeong, G. U. Lee, and D. B. Janes, Nanotechnology 18, 195202 (2007)]. Our…

Biological Physics · Physics 2013-02-06 Jianqing Qi , Neranjan Edirisinghe , M. Golam Rabbani , M. P. Anantram

A tandem cell is proposed for DNA sequencing in which an exonuclease enzyme cleaves bases (mononucleotides) from a strand of DNA for identification inside a nanopore. It has two nanopores and three compartments with the structure [cis1,…

Biomolecules · Quantitative Biology 2014-08-21 G. Sampath

Electrochemical Biosensors are uniquely positioned to offer real-time in vivo molecular sensing due to their robustness to both biofluids and contaminants found in biofluids, and their adaptability for the detection of different analytes by…

Biological Physics · Physics 2024-10-04 Philip S Lukeman

We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50mer agree with theoretical predictions, and the DNA…

DNA nanotechnology promises to provide controllable self-assembly on the nanoscale, allowing for the design of static structures, dynamic machines and computational architectures. In this article I review the state-of-the art of DNA…

Soft Condensed Matter · Physics 2015-07-13 Thomas E. Ouldridge

Charge migration along DNA molecules has attracted scientific interest for over half a century. Reports on possible high rates of charge transfer between donor and acceptor through the DNA, obtained in the last decade from solution…

Materials Science · Physics 2009-11-10 Danny Porath , Gianaurelio Cuniberti , Rosa Di Felice

Parts of DNA sequences known as exons and introns play very different role in coding and storage of genetic information. Here we show that their conducting properties are also very different. Taking into account long-range correlations…

Soft Condensed Matter · Physics 2015-05-14 A. A. Krokhin , V. M. K. Bagci , F. M. Izrailev , O. V. Usatenko , V. A. Yampol'skii

Graphene nanogaps and nanopores show potential for the purpose of electrical DNA sequencing, in particular because single-base resolution appears to be readily achievable. Here, we evaluated from first principles the advantages of a nanogap…

Mesoscale and Nanoscale Physics · Physics 2013-07-29 Jariyanee Prasongkit , Anton Grigoriev , Biswarup Pathak , Rajeev Ahuja , Ralph H. Scheicher

We study electronic transport in long DNA chains using the tight-binding approach for a ladder-like model of DNA. We find insulating behavior with localizaton lengths xi ~ 25 in units of average base-pair seperation. Furthermore, we observe…

Soft Condensed Matter · Physics 2007-05-23 Antonio Rodriguez , Rudolf A. Roemer , Matthew S. Turner

Solid-state nanopore and nanopipette sensors are powerful devices for the detection, quantification and structural analysis of biopolymers such as DNA and proteins, especially in carrier-enhanced resistive-pulse sensing. However, hundreds…

Mesoscale and Nanoscale Physics · Physics 2025-10-14 Cengiz J. Khan , Oliver J. Irving , Rand A. Al-Waqfi , Giorgio Ferrari , Tim Albrecht

In the field of DNA nanotechnology, it is common wisdom that charge transport occurs through the {\pi} stacked bases of double-stranded DNA. However, recent experimental findings by Zhuravel et. al. [Nat. Nanotech. 15, 836 (2020)] suggest…

Mesoscale and Nanoscale Physics · Physics 2024-12-31 Sourav Kundu , Siddhartha Lal

We study the electronic properties of DNA by way of a tight-binding model applied to four particular DNA sequences. The charge transfer properties are presented in terms of localisation lengths, crudely speaking the length over which…

Genomics · Quantitative Biology 2007-05-23 Daphne Klotsa , Rudolf A. Roemer , Matthew S. Turner
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