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A bioinformatics platform is introduced aimed at identifying models of disease-specific pathways, as well as a set of network measures that can quantify changes in terms of global structure or single link disruptions.The approach integrates…

Molecular Networks · Quantitative Biology 2012-01-17 A. Barla , S. Riccadonna , S. Masecchia , M. Squillario , M. Filosi , G. Jurman , C. Furlanello

Bayesian neural networks (BNNs) augment deep networks with uncertainty quantification by Bayesian treatment of the network weights. However, such models face the challenge of Bayesian inference in a high-dimensional and usually…

Machine Learning · Computer Science 2021-03-30 Zhijie Deng , Yucen Luo , Jun Zhu , Bo Zhang

Model-based diagnosis reasons backwards from a functional schematic of a system to isolate faults given observations of anomalous behavior. We develop a fully probabilistic approach to model based diagnosis and extend it to support…

Artificial Intelligence · Computer Science 2013-02-28 Sampath Srinivas

A general Bayesian framework for model selection on random network models regarding their features is considered. The goal is to develop a principle Bayesian model selection approach to compare different fittable, not necessarily nested,…

Methodology · Statistics 2020-04-30 Papamichalis Marios

Bayesian networks are now being used in enormous fields, for example, diagnosis of a system, data mining, clustering and so on. In spite of their wide range of applications, the statistical properties have not yet been clarified, because…

Machine Learning · Computer Science 2012-12-12 Keisuke Yamazaki , Sumio Watanbe

Network interpretation as an effort to reveal the features learned by a network remains largely visualization-based. In this paper, our goal is to tackle semantic network interpretation at both filter and decision level. For filter-level…

Computer Vision and Pattern Recognition · Computer Science 2021-11-22 Pei Guo , Ryan Farrell

Bayesian Belief Networks have been largely overlooked by Expert Systems practitioners on the grounds that they do not correspond to the human inference mechanism. In this paper, we introduce an explanation mechanism designed to generate…

Artificial Intelligence · Computer Science 2013-04-08 Peter Sember , Ingrid Zukerman

Increasingly sophisticated mathematical modelling processes from Machine Learning are being used to analyse complex data. However, the performance and explainability of these models within practical critical systems requires a rigorous and…

Machine Learning · Computer Science 2020-12-08 Xingyu Zhao , Alec Banks , James Sharp , Valentin Robu , David Flynn , Michael Fisher , Xiaowei Huang

We propose a new method for blind system identification. Resorting to a Gaussian regression framework, we model the impulse response of the unknown linear system as a realization of a Gaussian process. The structure of the covariance matrix…

Systems and Control · Computer Science 2016-05-20 Giulio Bottegal , Riccardo S. Risuleo , Håkan Hjalmarsson

This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local…

Fluid Dynamics · Physics 2019-10-02 Mitchel J. Colebank , M. Umar Qureshi , Mette S. Olufsen

Modern deterministic retrieval pipelines prioritize achieving state-of-the-art performance but often lack interpretability in decision-making. These models face challenges in assessing uncertainty, leading to overconfident predictions. To…

Information Retrieval · Computer Science 2024-02-06 EuiYul Song , Philhoon Oh , Sangryul Kim , James Thorne

Sensitivity analysis is an important part of a mathematical modeller's toolbox for model analysis. In this review paper, we describe the most frequently used sensitivity techniques, discussing their advantages and limitations, before…

Quantitative Methods · Quantitative Biology 2020-01-14 George Qian , Adam Mahdi

Numerical modeling of proton exchange membrane fuel cells is at the verge of becoming predictive. A crucial requisite for this, though, is that material properties of the membrane-electrode assembly and their functional dependence on the…

Applied Physics · Physics 2019-10-03 Roman Vetter , Jürgen O. Schumacher

We explore the relationship among model fidelity, experimental design, and parameter estimation in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many…

Quantitative Methods · Quantitative Biology 2017-02-08 Andrew White , Malachi Tolman , Howard D. Thames , Hubert Rodney Withers , Kathy A. Mason , Mark K. Transtrum

Decision circuits have been developed to perform efficient evaluation of influence diagrams [Bhattacharjya and Shachter, 2007], building on the advances in arithmetic circuits for belief network inference [Darwiche,2003]. In the process of…

Artificial Intelligence · Computer Science 2012-06-18 Debarun Bhattacharjya , Ross D. Shachter

Network analysis is an important tool in understanding the behavior of complex systems of interacting entities. However, due to the limitations of data gathering technologies, some interactions might be missing from the network model. This…

Social and Information Networks · Computer Science 2016-08-25 Soumya Sarkar , Sanjukta Bhowmick , Suhansanu Kumar , Animesh Mukherjee

The design of reliable indicators to anticipate critical transitions in complex systems is an im portant task in order to detect a coming sudden regime shift and to take action in order to either prevent it or mitigate its consequences. We…

Data Analysis, Statistics and Probability · Physics 2022-12-14 Martin Heßler , Oliver Kamps

We consider the bridge linear regression modeling, which can produce a sparse or non-sparse model. A crucial point in the model building process is the selection of adjusted parameters including a regularization parameter and a tuning…

Methodology · Statistics 2015-02-19 Shuichi Kawano

A central characteristic of Bayesian statistics is the ability to consistently incorporate prior knowledge into various modeling processes. In this paper, we focus on translating domain expert knowledge into corresponding prior…

Methodology · Statistics 2024-04-16 Florence Bockting , Stefan T. Radev , Paul-Christian Bürkner

This paper re-examines the problem of parameter estimation in Bayesian networks with missing values and hidden variables from the perspective of recent work in on-line learning [Kivinen & Warmuth, 1994]. We provide a unified framework for…

Machine Learning · Computer Science 2013-02-08 Eric Bauer , Daphne Koller , Yoram Singer
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