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Biological systems perform an astonishing array of dynamical processes -- including development and repair, regulation, behavior and motor control, sensing and signaling, and adaptation, among others. Powered by the transduction of stored…

Soft Condensed Matter · Physics 2025-09-04 James Clarke , Jake McGrath , Colin Johnson , José Alvarado

We study the time-optimal robust control of a two-level quantum system subjected to field inhomogeneities. We apply the Pontryagin Maximum Principle and we introduce a reduced space onto which the optimal dynamics is projected down. This…

Quantum Physics · Physics 2025-09-03 O. Fresse-Colson , S. Guérin , Xi Chen , D. Sugny

The ability to characterise a Hamiltonian with high precision is crucial for the implementation of quantum technologies. In addition to the well-developed approaches utilising optimal probe states and optimal measurements, the method of…

Quantum Physics · Physics 2022-12-14 Shushen Qin , Marcus Cramer , Christiane P. Koch , Alessio Serafini

We analyze the physics of optimal protocols to prepare a target state with high fidelity in a symmetrically coupled two-qubit system. By varying the protocol duration, we find a discontinuous phase transition, which is characterized by a…

Statistical Mechanics · Physics 2018-05-17 Marin Bukov , Alexandre G. R. Day , Phillip Weinberg , Anatoli Polkovnikov , Pankaj Mehta , Dries Sels

For two canonical examples of driven mesoscopic systems - a harmonically-trapped Brownian particle and a quantum dot - we numerically determine the finite-time protocols that optimize the compromise between the standard deviation and the…

Statistical Mechanics · Physics 2018-05-09 Alexandre P. Solon , Jordan M. Horowitz

Linear response theory has found many applications in statistical physics. One of these is to compute minimal-work protocols that drive nonequilibrium systems between different thermodynamic states, which are useful for designing engineered…

Statistical Mechanics · Physics 2026-01-19 Samuel. H. DAmbrosia , Adrianne Zhong , Michael R. DeWeese

In this paper, we consider the stochastic optimal control problem for the interacting particle system. We obtain the stochastic maximum principle of the optimal control system by introducing a generalized backward stochastic differential…

Probability · Mathematics 2025-05-14 Andrey A. Dorogovtsev , Yuecai Han , Kateryna Hlyniana , Yuhang Li

Nonadiabatic unitary evolution with tailored time-dependent Hamiltonians can prepare systems of cold atomic gases with various desired properties. For a system of two one-dimensional quasicondensates coupled with a time-varying tunneling…

Quantum Gases · Physics 2013-04-09 Armin Rahmani , Takuya Kitagawa , Eugene Demler , Claudio Chamon

Free energy landscapes encode the kinetics, intermediates, and transition states that govern molecular processes and are thus a key target of single biomolecule research. Typical approaches to deriving optimal, error-minimizing,…

Biological Physics · Physics 2025-11-25 Oliver Cheng , Zosia Adamska , Michael P. Brenner , Megan C. Engel

Biological and living organisms sense and process information from their surroundings, typically having access only to a subset of external observables for a limited amount of time. In this work, we uncover how biological systems can…

Statistical Mechanics · Physics 2024-10-10 Giorgio Nicoletti , Daniel Maria Busiello

Phase separation has emerged as an essential concept for the spatial organization inside biological cells. However, despite the clear relevance to virtually all physiological functions, we understand surprisingly little about what phases…

Biological Physics · Physics 2022-08-10 David Zwicker , Liedewij Laan

In the case of quantum systems interacting with multiple environments, the time-evolution of the reduced density matrix is described by the Liouvillian. For a variety of physical observables, the long-time limit or steady state solution is…

Quantum Physics · Physics 2022-01-05 Rodrigo A. Vargas-Hernández , Ricky T. Q. Chen , Kenneth A. Jung , Paul Brumer

The process of dynamic state estimation (filtering) based on point process observations is in general intractable. Numerical sampling techniques are often practically useful, but lead to limited conceptual insight about optimal…

Machine Learning · Statistics 2015-08-04 Yuval Harel , Ron Meir , Manfred Opper

By means of optimal control techniques we model and optimize the manipulation of the external quantum state (center-of-mass motion) of atoms trapped in adjustable optical potentials. We consider in detail the cases of both non interacting…

We consider irreversible and coupled reversible-irreversible nonlinear port-Hamiltonian systems and the respective sets of thermodynamic equilibria. In particular, we are concerned with optimal state transitions and output stabilization on…

Optimization and Control · Mathematics 2024-10-08 Friedrich Philipp , Manuel Schaller , Karl Worthmann , Timm Faulwasser , Bernhard Maschke

This paper studies the decay of an objective functional using a new control technique within Pontryagin's framework. Convergence analysis is carried out on the infinite-dimensional space of Tokamak plasma dynamical state as described by…

Optimization and Control · Mathematics 2025-11-10 Slim Jmal , Matteo Tacchi-Bénard , Emmanuel Witrant

In this paper we study the optimal control of a parabolic initial-boundary value problem of Allen--Cahn type with dynamic boundary conditions. Phase field systems of this type govern the evolution of coupled diffuse phase transition…

Optimization and Control · Mathematics 2023-03-30 Jürgen Sprekels , Fredi Tröltzsch

Motivation: Many biochemical pathways are known, but the numerous parameters required to correctly explore the dynamics of the pathways are not known. For this reason, algorithms that can make inferences by looking at the topology of a…

Molecular Networks · Quantitative Biology 2009-07-23 Deepak Chandran , Herbert M. Sauro

We experimentally and theoretically study the thermodynamically optimal control of interacting multiple-particle systems, focusing on collections of colloidal particles individually confined in optical traps. We investigate protocols that…

Soft Condensed Matter · Physics 2026-03-19 Samuel Monter , Lars T. Stutzer , Sarah A. M. Loos , Clemens Bechinger

A robust energy transfer mechanism is found in nonlinear wave systems, which favours transfers towards modes interacting via non-resonant triads, applicable in meteorology, nonlinear optics and plasma wave turbulence. Transfer efficiency is…

Fluid Dynamics · Physics 2013-09-03 Miguel D. Bustamante , Brenda Quinn