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The continually increasing volume of DNA sequence data has resulted in a growing demand for fast implementations of core algorithms. Computation of pairwise alignments between candidate haplotypes and sequencing reads using Pair-HMMs is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-27 Bertil Schmidt , Felix Kallenborn , Alexander Wichmann , Alejandro Chacon , Christian Hundt

Pairwise sequence alignment is one of the most computationally intensive kernels in genomic data analysis, accounting for more than 90% of the runtime for key bioinformatics applications. This method is particularly expensive for…

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Genomic sequence alignment is an important research topic in bioinformatics and continues to attract significant efforts. As genomic data grow exponentially, however, most of alignment methods face challenges due to their huge computational…

Computational Engineering, Finance, and Science · Computer Science 2018-06-07 Hanyu Jiang , Narayan Ganesan , Yu-Dong Yao

Vector similarity search has become a critical component in AI-driven applications such as large language models (LLMs). To achieve high recall and low latency, GPUs are utilized to exploit massive parallelism for faster query processing.…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-03 Yi Liu , Chen Qian

In this paper, we present the design of a sample sort algorithm for manycore GPUs. Despite being one of the most efficient comparison-based sorting algorithms for distributed memory architectures its performance on GPUs was previously…

Data Structures and Algorithms · Computer Science 2009-10-01 Nikolaj Leischner , Vitaly Osipov , Peter Sanders

Current AI code generation systems suffer from significant latency bottlenecks due to CPU-GPU data transfers during compilation, execution, and testing phases. We establish theoretical foundations for three complementary approaches to…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-12-15 Adilet Metinov , Gulida M. Kudakeeva , Gulnara D. Kabaeva

Subgraph matching is a basic operation widely used in many applications. However, due to its NP-hardness and the explosive growth of graph data, it is challenging to compute subgraph matching, especially in large graphs. In this paper, we…

Databases · Computer Science 2021-02-25 Xin Jin , Zhengyi Yang , Xuemin Lin , Shiyu Yang , Lu Qin , You Peng

Heterogeneity in the cell population of cancer tissues poses many challenges in cancer diagnosis and treatment. Studying the heterogeneity in cell populations from gene expression measurement data in the context of cancer research is a…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-01-31 Anik Chaudhuri , Anwoy Mohanty , Manoranjan Satpathy

Not only with the large host memory for supporting large scale graph processing, GPU-accelerated heterogeneous architecture can also provide a great potential for high-performance computing. However, few existing heterogeneous systems can…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-06-05 Xianliang Li

Genome sequence alignment is the core of many biological applications. The advancement of sequencing technologies produces a tremendous amount of data, making sequence alignment a critical bottleneck in bioinformatics analysis. The existing…

Hardware Architecture · Computer Science 2023-01-26 Weihong Xu , Saransh Gupta , Niema Moshiri , Tajana Rosing

Computing on graphics processors is maybe one of the most important developments in computational science to happen in decades. Not since the arrival of the Beowulf cluster, which combined open source software with commodity hardware to…

Mathematical Software · Computer Science 2011-09-21 Felipe A. Cruz , Simon K. Layton , Lorena A. Barba

Analysis of processing time and similarity of images generated between CPU and GPU architectures and sequential and parallel programming. For image processing a computer with AMD FX-8350 processor and an Nvidia GTX 960 Maxwell GPU was used,…

We evolve floating point Sextic polynomial populations of genetic programming binary trees for up to a million generations. Programs with almost four hundred million instructions are created by crossover. To support unbounded Long-Term…

Neural and Evolutionary Computing · Computer Science 2019-02-26 W. B. Langdon , W. Banzhaf

Fully homomorphic encryption (FHE) enables direct computation on encrypted data, making it a crucial technology for privacy protection. However, FHE suffers from significant performance bottlenecks. In this context, GPU acceleration offers…

Cryptography and Security · Computer Science 2024-10-10 Zhiwei Wang , Haoqi He , Lutan Zhao , Peinan Li , Zhihao Li , Dan Meng , Rui Hou

Optimal usage of the memory system is a key element of fast GPU algorithms. Unfortunately many common algorithms fail in this regard despite exhibiting great regularity in memory access patterns. In this paper we propose efficient kernels…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-07-18 Mathis Bouverot-Dupuis , Mary Sheeran

Tree-based Genetic Programming (TGP) is a widely used evolutionary algorithm for tasks such as symbolic regression, classification, and robotic control. Due to the intensive computational demands of running TGP, GPU acceleration is crucial…

Neural and Evolutionary Computing · Computer Science 2026-02-17 Zhihong Wu , Lishuang Wang , Kebin Sun , Zhuozhao Li , Ran Cheng

Large-scale observational health databases are increasingly popular for conducting comparative effectiveness and safety studies of medical products. However, increasing number of patients poses computational challenges when fitting survival…

Computation · Statistics 2023-10-26 Jianxiao Yang , Martijn J. Schuemie , Xiang Ji , Marc A. Suchard

Making inferences with a deep neural network on a batch of states is much faster with a GPU than making inferences on one state after another. We build on this property to propose Monte Carlo Tree Search algorithms using batched inferences.…

Artificial Intelligence · Computer Science 2021-04-12 Tristan Cazenave

Graphics Processing Units allow for running massively parallel applications offloading the CPU from computationally intensive resources, however GPUs have a limited amount of memory. In this paper a trie compression algorithm for massively…

Data Structures and Algorithms · Computer Science 2017-02-20 Xavier Bellekens , Amar Seeam , Christos Tachtatzis , Robert Atkinson