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The paper investigates the problem of fitting protein complexes into electron density maps. They are represented by high-resolution cryoEM density maps converted into overlapping matrices and partly show a structure of a complex. The…

Optimization and Control · Mathematics 2017-01-10 Roman Pogodin , Alexander Katrutsa , Sergei Grudinin

Despite the numerous uses of semidefinite programming (SDP) and its universal solvability via interior point methods (IPMs), it is rarely applied to practical large-scale problems. This mainly owes to the computational cost of IPMs that…

Optimization and Control · Mathematics 2024-03-19 Yifan Ran , Stefan Vlaski , Wei Dai

Near-term quantum computers will operate in a noisy environment, without error correction. A critical problem for near-term quantum computing is laying out a logical circuit onto a physical device with limited connectivity between qubits.…

Hardware Architecture · Computer Science 2022-08-30 Abtin Molavi , Amanda Xu , Martin Diges , Lauren Pick , Swamit Tannu , Aws Albarghouthi

Given the limitations of current hardware, the theoretical gains promised by quantum computing remain unrealized across practical applications. But the gap between theory and hardware is closing, assisted by developments in quantum…

Quantum Physics · Physics 2023-10-30 Elena R. Henderson , Harsha Nagarajan , Carleton Coffrin

In this paper, a class of optimization problems with nonlinear inequality constraints is discussed. Based on the ideas of sequential quadratic programming algorithm and the method of strongly sub-feasible directions, a new superlinearly…

Optimization and Control · Mathematics 2012-06-28 Jin-Bao Jian , Chuan-Hao Guo , Chun-Ming Tang , Yan-Qin Bai

Binary quadratic programming problems have attracted much attention in the last few decades due to their potential applications. This type of problems are NP-hard in general, and still considered a challenge in the design of efficient…

Data Structures and Algorithms · Computer Science 2014-11-20 Khaled Elbassioni , Trung Thanh Nguyen

We propose a quantum-assisted framework for solving constrained finite-horizon nonlinear optimal control problems using a barrier Sequential Quadratic Programming (SQP) approach. Within this framework, a quantum subroutine is incorporated…

Quantum Physics · Physics 2025-10-22 Nahid Binandeh Dehaghani , Rafal Wisniewski , A. Pedro Aguiar

Quadratic Unconstrained Binary Optimization (QUBO or UBQP) is concerned with maximizing/minimizing the quadratic form $H(J, \eta) = W \sum_{i,j} J_{i,j} \eta_{i} \eta_{j}$ with $J$ a matrix of coefficients, $\eta \in \{0, 1\}^N$ and $W$ a…

Probability · Mathematics 2024-07-02 Marco Isopi , Benedetto Scoppola , Alessio Troiani

In this article, a globally convergent sequential quadratic programming (SQP) method is developed for multi-objective optimization problems with inequality type constraints. A feasible descent direction is obtained using a linear…

Optimization and Control · Mathematics 2020-05-20 Md Abu Talhamainuddin Ansary , Geetanjali Panda

We study the ternary quadratic problem (TQP), a quadratic optimization problem with linear constraints where the variables take values in $\{0, \pm 1\}$. While semidefinite programming (SDP) techniques are well established for $\{0,1\}$-…

Optimization and Control · Mathematics 2026-04-01 Frank de Meijer , Veronica Piccialli , Renata Sotirov , Antonio M. Sudoso

In this paper, we investigate a special class of quadratic-constrained quadratic programming (QCQP) with semi-definite constraints. Traditionally, since such a problem is non-convex and N-hard, the neural network (NN) is regarded as a…

Machine Learning · Computer Science 2024-07-10 Xiucheng Wang , Qi Qiu , Nan Cheng

We investigate unitary and state $t$-designs from a computational complexity perspective. First, we address the problems of computing frame potentials that characterize (approximate) $t$-designs. We present a quantum algorithm for computing…

Quantum Physics · Physics 2025-09-17 Yoshifumi Nakata , Yuki Takeuchi , Martin Kliesch , Andrew Darmawan

We present a unified quantum-classical framework for addressing NP-complete constrained combinatorial optimization problems, generalizing the recently proposed Quantum Conic Programming (QCP) approach. Accordingly, it inherits many…

Quantum Physics · Physics 2024-11-04 Lennart Binkowski , Tobias J. Osborne , Marvin Schwiering , René Schwonnek , Timo Ziegler

We analyze a sequential quadratic programming algorithm for solving a class of abstract optimization problems. Assuming that the initial point is in an $L^2$ neighborhood of a local solution that satisfies no-gap second-order sufficient…

Optimization and Control · Mathematics 2026-05-19 Eduardo Casas , Mariano Mateos

Quadratically constrained quadratic programming (QCQP) has long been recognized as a computationally challenging problem, particularly in large-scale or high-dimensional settings where solving it directly becomes intractable. The complexity…

Optimization and Control · Mathematics 2025-10-09 Shuai Li , Shenglong Zhou , Ziyan Luo

Given a matrix $A \in \mathbb{R}^{n\times n}$, we consider the problem of maximizing $x^TAx$ subject to the constraint $x \in \{-1,1\}^n$. This problem, called MaxQP by Charikar and Wirth [FOCS'04], generalizes MaxCut and has natural…

Data Structures and Algorithms · Computer Science 2020-12-16 Danny Hermelin , Leon Kellerhals , Rolf Niedermeier , Rami Pugatch

This paper presents and analyzes the first matrix optimization model which allows general coordinate and spectral constraints. The breadth of problems our model covers is exemplified by a lengthy list of examples from the literature,…

Optimization and Control · Mathematics 2024-10-15 Casey Garner , Gilad Lerman , Shuzhong Zhang

We consider a parametric convex quadratic programming, CQP, relaxation for the quadratic knapsack problem, QKP. This relaxation maintains partial quadratic information from the original QKP by perturbing the objective function to obtain a…

Optimization and Control · Mathematics 2019-06-11 Marcia Fampa , Daniela Cristina Lubke , Fei Wang , Henry Wolkowicz

Quadratic Unconstrained Binary Optimization (QUBO) is a broad class of optimization problems with many practical applications. To solve its hard instances in an exact way, known classical algorithms require exponential time and several…

Quantum Physics · Physics 2021-01-21 Gian Giacomo Guerreschi

We propose a data-driven framework for efficiently solving quadratic programming (QP) problems by reducing the number of variables in high-dimensional QPs using instance-specific projection. A graph neural network-based model is designed to…

Machine Learning · Statistics 2025-10-31 Tomoharu Iwata , Futoshi Futami