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Extensive research has been carried out for at least 50 years to understand the mechanical properties of brain tissue in order to understand the mechanisms of traumatic brain injury (TBI). The observed large variability in experimental…

Medical Physics · Physics 2013-03-04 Badar Rashid , Michel Destrade , Michael Gilchrist

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…

Biological Physics · Physics 2013-02-20 Badar Rashid , Michel Destrade , Michael Gilchrist

Mechanical characterization of brain tissue has been investigated extensively by various research groups over the past fifty years. These properties are particularly important for modelling Traumatic Brain Injury (TBI). In this research, we…

Medical Physics · Physics 2013-03-04 Badar Rashid , Michel Destrade , Michael D. Gilchrist

Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…

Soft Condensed Matter · Physics 2025-12-23 G. Small , F. Ballatore , C. Giverso , V. Balbi

During severe impact conditions, brain tissue experiences a rapid and complex deformation, which can be seen as a mixture of compression, tension and shear. Moreover, diffuse axonal injury (DAI) occurs in animals and humans when both the…

Soft Condensed Matter · Physics 2020-09-04 Badar Rashid , Michel Destrade , Michael D. Gilchrist

Mechanical characterization of brain tissue at high loading velocities is crucial for modeling Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences compression, tension and shear. Limited experimental data…

Soft Condensed Matter · Physics 2020-09-03 Badar Rashid , Michel Destrade , Michael D. Gilchrist

The large variability in experimentally measured mechanical properties of brain tissue is due to many factors including heterogeneity, anisotropy, age dependence and post-mortem time. Moreover, differences in test protocols also influence…

Soft Condensed Matter · Physics 2013-06-04 Badar Rashid , Michel Destrade , Michael Gilchrist

In this study an upper bound analysis for cylindrical "Barrel Compression Test" (BCT) is developed. BCT method is a very simple method which can be utilized in order to evaluate quantitatively the coefficient of friction by means of just…

Materials Science · Physics 2014-02-28 Soheil Solhjoo

Computational biomechanics models of the brain have become an important tool for investigating the brain responses to mechanical loads. The geometry, loading conditions, and constitutive properties of such brain models are well-studied and…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Sajjad Arzemanzadeh , Benjamin Zwick , Karol Miller , Tim Rosenow , Stuart I. Hodgetts , Adam Wittek

The mechanical response of elastic porous media confined within rigid geometries is central to a wide range of industrial, geological, and biomedical systems. However, current models for these problems typically overlook the role of wall…

Soft Condensed Matter · Physics 2026-03-12 Térence Desclaux , Callum Cuttle , Chris W. MacMinn , Olivier Liot

We investigate experimentally and model theoretically the mechanical behaviour of brain matter in torsion. Using a strain-controlled rheometer we perform torsion tests on fresh porcine brain samples. We quantify the torque and the normal…

Soft Condensed Matter · Physics 2020-01-06 Valentina Balbi , Antonia Trotta , Michel Destrade , Aisling Ní Annaidh

In our analysis, we show that what Cottenden et al. accomplish is the derivation of the ordinary capstan equation, and a solution to a dynamic membrane with both a zero-Poisson's ratio and a zero-mass density on a rigid right-circular cone.…

Medical Physics · Physics 2021-01-20 Kavinda Jayawardana

Microscale dynamic testing is vital to the understanding of material behavior at application relevant strain rates. However, despite two decades of intense micromechanics research, the testing of microscale metals has been largely limited…

To determine the friction coefficient of graphene, micro-scale scratch tests are conducted on exfoliated and epitaxial graphene at ambient conditions. The experimental results show that the monolayer, bilayer, and trilayer graphene all…

Brain tissue is a heterogeneous material, constituted by a soft matrix filled with cerebrospinal fluid. The interactions between, and the complexity of each of these components are responsible for the non-linear rate-dependent behaviour…

Quantitative Methods · Quantitative Biology 2021-02-23 Michele Terzano , Andrea Spagnoli , Daniele Dini , Antonio Elia Forte

Mechanical models of brain tissue are a beneficial tool to simulate neurosurgical interventions, disease progression, or brain development. However, the accuracy and predictive capacity of such a model relies on a precise experimental…

Medical Physics · Physics 2026-05-29 Laura Ruhland , Nina Reiter , Silvia Budday , Kai Willner

We show that porcine brain matter can be modelled accurately as a very soft rubber-like material using the Mooney-Rivlin strain energy function, up to strains as high as 60\%. This result followed from simple shear experiments performed on…

Soft Condensed Matter · Physics 2020-09-15 Michel Destrade , Michael D. Gilchrist , Jerry G. Murphy , Badar Rashid , Giuseppe Saccomandi

The aim of the presented study is to identify some properties of the dynamic behavior of the cancellous bone and to identify the link between this mechanical behavior and the microstructural properties. 7 cylinders of bovine cancellous bone…

Medical Physics · Physics 2009-11-30 Sébastien Laporte , Franck David , Valérie Bousson , Stephane Pattofatto

By using the Kirkwood formula, the friction coefficient of a solvated Brownian particle is determined from the integration on time of the autocorrelation function of the force that the solvent exerts on this particle. Extensive molecular…

Statistical Mechanics · Physics 2009-11-07 F. Ould Kaddour , D. Levesque

We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves…

Soft Condensed Matter · Physics 2020-09-02 Yi Jiang , Guoyang Li , Lin-Xue Qian , Si Liang , Michel Destrade , Yanping Cao
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