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Mild traumatic brain injuries (mTBI) are a highly prevalent condition with heterogeneous outcomes between individuals. A key factor governing brain tissue deformation and the risk of mTBI is the rotational kinematics of the head.…
Finite element models of the thorax are under development to assist vehicle safety researchers with the design of countermeasures such as advanced restrain systems. Computational models have become more refined with increasing geometrical…
Treatment of acute ischemic strokes (AIS) is largely contingent upon the time since stroke onset (TSS). However, TSS may not be readily available in up to 25% of patients with unwitnessed AIS. Current clinical guidelines for patients with…
Tractography algorithms are used extensively to delineate white matter structures, by operating on the voxel-wise information generated through the application of diffusion tensor imaging (DTI) or other models to diffusion weighted (DW)…
This report describes technical adaptations of a traumatic brain injury (TBI) model-largely inspired by Marmarou-in order to monitor microdialysis data and PtiO2 (brain tissue oxygen) before, during and after injury. We particularly…
The scope of this study is to understand the strength behaviour and fragment size of rocks during indirect, quasi-static, and dynamic tensile tests. Four rocks with different lithological characteristics namely, basalt, granite, sandstone…
Traumatic brain injuries (TBI) are considered a silent epidemic. It affects many people, from automobiles to sports to service members. In this study, we employed a musculoskeletal head-neck model to understand the effect of impact…
Wearable sensors for measuring head kinematics can be noisy due to imperfect interfaces with the body. Mouthguards are used to measure head kinematics during impacts in traumatic brain injury (TBI) studies, but deviations from reference…
Traumatic brain injury (TBI) disrupts thalamocortical connectivity, contributing to cognitive impairment and post-traumatic epilepsy (PTE). This study presents a novel tractography-based framework that leverages diffusion maps to capture…
In the real world, the severity of traumatic injuries are measured using the Abbreviated Injury Scale (AIS). However the AIS scale cannot currently be computed by using finite element human computer models, which calculate a maximum…
Machine learning head models (MLHMs) are developed to estimate brain deformation for early detection of traumatic brain injury (TBI). However, the overfitting to simulated impacts and the lack of generalizability caused by distributional…
Electromagnetic stimulation of the human brain is a key tool for the neurophysiological characterization and diagnosis of several neurological disorders. Transcranial magnetic stimulation (TMS) is one procedure that is commonly used…
Computed Tomography (CT) is commonly used to image acute ischemic stroke (AIS) patients, but its interpretation by radiologists is time-consuming and subject to inter-observer variability. Deep learning (DL) techniques can provide automated…
The Federal Interagency Traumatic Brain Injury Research (FITBIR) database is a centralized data repository for traumatic brain injury (TBI) research. It includes over 45,529 magnetic resonance images (MRI) from 6,211 subjects (9,229 imaging…
A fatigue-failure process is hypothesized to govern the development of tibial stress fractures, where bone damage is highly dependent on the peak strain magnitude. To date, much of the work examining tibial strains during running has…
The mechanisms by which blast pressure waves cause mild to moderate traumatic brain injury (mTBI) are an open question. Possibilities include acceleration of the head, direct passage of the blast wave via the cranium, and propagation of the…
The current methods of assessing tendon health such as clinical examination, imaging techniques, and implanted pressure sensors, are often based on a subjective assessment or are not accurate enough, are extremely expensive, or are limited…
A crystal plasticity theory was developed for use in simulations of dynamic loading at high pressures and strain rates. At pressures of the order of the bulk modulus, compressions o(100%) may be induced. At strain rates o(10^9)/s or higher,…
Axon radius is a potential biomarker for brain diseases and a crucial tissue microstructure parameter that determines the speed of action potentials. Diffusion MRI (dMRI) allows non-invasive estimation of axon radius, but accurately…
Diffusion-weighted magnetic resonance imaging (dMRI) is widely used to assess the brain white matter. One of the most common computations in dMRI involves cross-subject tract-specific analysis, whereby dMRI-derived biomarkers are compared…