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Evolutionary success depends on the capacity to adapt: organisms must respond to environmental challenges through both genetic innovation and lifetime learning. The gene-centric paradigm attributes evolutionary causality exclusively to…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Nam H. Le

The development of multicellular organisms entails a deep connection between time-dependent biochemical processes taking place at the subcellular level, and the resulting macroscopic phenotypes that arise in populations of up to trillions…

Biological Physics · Physics 2025-10-07 Ben Ansbacher , Malachy Guzman , Jordi Garcia-Ojalvo , Arjendu K Pattanayak

Enzymes are on the front lines of evolution. All living organisms rely on highly efficient, specific enzymes for growth, sustenance, and reproduction; and many diseases are a consequence of a mutation on an enzyme that affects its catalytic…

Molecular Networks · Quantitative Biology 2009-01-07 Nilou Ataie

This paper presents a real-time simulation involving ''protozoan-like'' cells that evolve by natural selection in a physical 2D ecosystem. Selection pressure is exerted via the requirements to collect mass and energy from the surroundings…

Neural and Evolutionary Computing · Computer Science 2023-05-23 Dylan Cope

How does growth encode form in developing organisms? Many different spatiotemporal growth profiles may sculpt tissues into the same target 3D shapes, but only specific growth patterns are observed in animal and plant development. In…

Soft Condensed Matter · Physics 2023-02-16 Dillon J. Cislo , Anastasios Pavlopoulos , Boris I. Shraiman

In many species, genomic data have revealed pervasive adaptive evolution indicated by the fixation of beneficial alleles. However, when selection pressures are highly variable along a species range or through time adaptive alleles may…

Populations and Evolution · Quantitative Biology 2014-11-10 Alan O. Bergland , Emily L. Behrman , Katherine R. O'Brien , Paul S. Schmidt , Dmitri A. Petrov

When mutation rates are low, natural selection remains effective, and increasing the mutation rate can give rise to an increase in adaptation rate. When mutation rates are high to begin with, however, increasing the mutation rate may have a…

Populations and Evolution · Quantitative Biology 2012-11-06 Philip Gerrish , Alexandre Colato , Paul Sniegowski

This paper investigates the influence of genotype size on evolutionary algorithms' performance. We consider genotype compression (where genotype is smaller than phenotype) and expansion (genotype is larger than phenotype) and define…

Neural and Evolutionary Computing · Computer Science 2021-05-26 Lucija Planinic , Marko Djurasevic , Luca Mariot , Domagoj Jakobovic , Stjepan Picek , Carlos Coello Coello

Cells adapt to different conditions by altering a vast number of components, which is measurable using transcriptome analysis. Given that a cell undergoing steady growth is constrained to sustain each of its internal components, the…

Cell Behavior · Quantitative Biology 2014-07-15 Kunihiko Kaneko , Chikara Furusawa , Tetsuya Yomo

The adaptation rate in theoretical models of biological evolution increases with the mutation rate but only to a point when mutations into lethal states cause extinction. One would expect that removing such states should be beneficial for…

Populations and Evolution · Quantitative Biology 2024-06-27 Viktoria Blavatska , Bartlomiej Waclaw

The emergence of agriculture is suggested to have driven extensive human population growths. However, genetic evidence from maternal mitochondrial genomes suggests major population expansions began before the emergence of agriculture.…

Populations and Evolution · Quantitative Biology 2013-11-28 Chuan-Chao Wang , Yunzhi Huang , Shao-Qing Wen , Chun Chen , Li Jin , Hui Li

Chromosomal rearrangements, which shuffle DNA throughout the genome, are an important source of divergence across taxa. Using a paired-end read approach with Illumina sequence data for archaic humans, I identify changes in genome structure…

Genomics · Quantitative Biology 2015-10-07 Rebekah L. Rogers

Transfer RNAs (tRNAs) are essential components of the translational machinery. Their abundance and diversity shape decoding capacity and protein synthesis efficiency and accuracy. Because tRNA abundance is encoded in the genome through tDNA…

Populations and Evolution · Quantitative Biology 2026-04-30 Guillaume Hummel , David Pflieger , Valerie Cognat , Laurence Drouard , Alexandre Berr

The rate of recombination affects the mode of molecular evolution. In high-recombining sequence, the targets of selection are individual genetic loci; under low recombination, selection collectively acts on large, genetically linked genomic…

Populations and Evolution · Quantitative Biology 2017-11-30 Stephan Schiffels , Ville Mustonen , Michael Lässig

The concept of fitness as a measure for a species's success in natural selection is central to the theory of evolution. We here investigate how reproduction rates which are not constant but vary in response to environmental fluctuations,…

Populations and Evolution · Quantitative Biology 2015-10-21 Anna Melbinger , Massimo Vergassola

In general, cellular phenotypes, as measured by concentrations of cellular components, involve large degrees of freedom. However, recent measurement has demonstrated that phenotypic changes resulting from adaptation and evolution in…

Populations and Evolution · Quantitative Biology 2020-03-04 Takuya U. Sato , Kunihiko Kaneko

Understanding the influence of an environment on the evolution of its resident population is a major challenge in evolutionary biology. Great progress has been made in homogeneous population structures while heterogeneous structures have…

Populations and Evolution · Quantitative Biology 2014-07-30 Wes Maciejewski , Gregory J. Puleo

An ongoing debate in evolutionary biology is whether phenotypic change occurs predominantly around the time of speciation or whether it instead accumulates gradually over time. In this work I propose a general framework incorporating both…

Populations and Evolution · Quantitative Biology 2014-07-02 Krzysztof Bartoszek

Rhizomes play fundamental roles in plant evolution, persistence, and environmental adaptation by enabling clonal propagation, resource storage, and stress resilience. Despite their ecological and agronomic importance across diverse plant…

Populations and Evolution · Quantitative Biology 2026-01-19 Hongfei Chen , Jenn M. Coughlan

Biological genotypes do not code directly for phenotypes; developmental physiology is the control layer that separates genomes from capacities ascertained by selection. A key aspect is competency, as cells are not a passive material but…

Populations and Evolution · Quantitative Biology 2022-08-01 Lakshwin Shreesha , Michael Levin