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Related papers: Muller's ratchet with overlapping generations

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We use traveling-wave theory to derive expressions for the rate of accumulation of deleterious mutations under Muller's ratchet and the speed of adaptation under positive selection in asexual populations. Traveling-wave theory is a…

Populations and Evolution · Quantitative Biology 2007-12-19 Igor M. Rouzine , Eric Brunet , Claus O. Wilke

The drift-barrier hypothesis states that random genetic drift constrains the refinement of a phenotype under natural selection. The influence of effective population size and the genome-wide deleterious mutation rate were studied…

Populations and Evolution · Quantitative Biology 2024-07-25 Luis A. La Rocca , Konrad Gerischer , Anton Bovier , Peter M. Krawitz

Models for viral populations with high replication error rates (such as RNA viruses) rely on the quasispecies concept, in which mutational pressure beyond the so-called "Error Threshold" leads to a loss of essential genetic information and…

Biological Physics · Physics 2025-02-26 David A. Herrera-Martí

The Moran discrete process and the Wright-Fisher modelare the most popular models in population genetics. It is common tounderstand the dynamics of these models to use an approximating diffusionprocess, called Wright-Fisher diffusion. Here,…

Probability · Mathematics 2019-05-13 Gorgui Gackou , A Guillin , Arnaud Personne

We consider the dynamics of a non-recombining haploid population of finite size which accumulates deleterious mutations irreversibly. This ratchet like process occurs at a finite speed in the absence of epistasis, but it has been suggested…

Populations and Evolution · Quantitative Biology 2008-08-18 Kavita Jain

We consider two versions of stochastic population models with mutation and selection. The first approach relies on a multitype branching process; here, individuals reproduce and change type (i.e., mutate) independently of each other,…

Populations and Evolution · Quantitative Biology 2009-02-19 E. Baake , R. Bialowons

Consider a two-type Moran population of size $N$ with selection and mutation, where the selective advantage of the fit individuals is amplified at extreme environmental conditions. Assume selection and mutation are weak with respect to $N$,…

Probability · Mathematics 2023-04-26 Fernando Cordero , Grégoire Véchambre

The Wright-Fisher model and the Moran model are both widely used in population genetics. They describe the time evolution of the frequency of an allele in a well-mixed population with fixed size. We propose a simple and tractable model…

Populations and Evolution · Quantitative Biology 2024-12-30 Arthur Alexandre , Alia Abbara , Cecilia Fruet , Claude Loverdo , Anne-Florence Bitbol

I study a population model in which the reproduction rate lambda is inherited with mutation, favoring fast reproducers in the short term, but conflicting with a process that eliminates agglomerations of individuals. The model is a variant…

Statistical Mechanics · Physics 2021-06-02 Ronald Dickman

Sexually reproducing populations with small number of individuals may go extinct by stochastic fluctuations in sex determination, causing all their members to become male or female in a generation. In this work we calculate the time to…

Populations and Evolution · Quantitative Biology 2012-10-24 David M. Schneider , Eduardo do Carmo , Yaneer Bar-Yam , Marcus A. M. de Aguiar

If deleterious mutations near a fitness maximum in a spatially distributed population are sufficiently frequent or detrimental, the population can undergo a fitness collapse, similarly to the Muller's ratchet effect in well-mixed…

Statistical Mechanics · Physics 2015-06-02 Maxim O. Lavrentovich

Temporal environmental variations are ubiquitous in nature, yet most of the theoretical works in population genetics and evolution assume fixed environment. Here we analyze the effect of variations in carrying capacity on the fate of a…

Populations and Evolution · Quantitative Biology 2019-12-16 Immanuel Meyer , Nadav M. Shnerb

We study stochastic evolutionary game dynamics in a population of finite size. Individuals in the population are divided into two dynamically evolving groups. The structure of the population is formally described by a Wright-Fisher type…

Probability · Mathematics 2020-07-01 Timothy Chumley , Ozgur Aydogmus , Anastasios Matzavinos , Alexander Roitershtein

Several groups have recently modeled evolutionary transitions from an ancestral allele to a beneficial allele separated by one or more intervening mutants. The beneficial allele can become fixed if a succession of intermediate mutants are…

Populations and Evolution · Quantitative Biology 2011-07-14 Stephen R Proulx

Evolution occurs in populations of reproducing individuals. In stochastic descriptions of evolutionary dynamics, such as the Moran process, individuals are chosen randomly for birth and for death. If the same type is chosen for both steps,…

Populations and Evolution · Quantitative Biology 2026-01-13 Michal Pecho , Josef Tkadlec , Martin A. Nowak

We are interested in modelling Darwinian evolution, resulting from the interplay of phenotypic variation and natural selection through ecological interactions. Our models are rooted in the microscopic, stochastic description of a population…

Probability · Mathematics 2016-08-16 Nicolas Champagnat , Régis Ferrière , Sylvie Méléard

The Moran process, as studied by [Lieberman, E., Hauert, C. and Nowak, M. Evolutionary dynamics on graphs. Nature 433, pp. 312-316 (2005)], is a stochastic process modeling the spread of genetic mutations in populations. In this process,…

Populations and Evolution · Quantitative Biology 2021-07-27 Themistoklis Melissourgos , Sotiris Nikoletseas , Christoforos Raptopoulos , Paul Spirakis

The aim of this paper is to study the large population limit of a binary branching particle system with Moran type interactions: we introduce a new model where particles evolve, reproduce and die independently and, with a probability that…

Probability · Mathematics 2024-04-12 Alexander M. G. Cox , Emma Horton , Denis Villemonais

In evolutionary games the fitness of individuals is not constant but depends on the relative abundance of the various strategies in the population. Here we study general games among n strategies in populations of large but finite size. We…

Populations and Evolution · Quantitative Biology 2009-05-16 Tibor Antal , Arne Traulsen , Hisashi Ohtsuki , Corina E. Tarnita , Martin A. Nowak

Community assembly is studied using individual-based multispecies models. The models have stochastic population dynamics with mutation, migration, and extinction of species. Mutants appear as a result of mutation of the resident species,…

Populations and Evolution · Quantitative Biology 2010-05-18 Yohsuke Murase , Takashi Shimada , Nobuyasu Ito , Per Arne Rikvold