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Deterministic and stochastic Boolean network models are build for the dynamics of negative feedback loops of the p53 pathways. It is shown that the main function of the negative feedback in the p53 pathways is to keep p53 at a low steady…
Parkinson's disease (PD) is a neurodegenerative condition characterized by frequently changing motor symptoms, necessitating continuous symptom monitoring for more targeted treatment. Classical time series classification and deep learning…
Parkinson's Disease (PD) is associated with gait movement disorders, such as bradykinesia, stiffness, tremors and postural instability, caused by progressive dopamine deficiency. Today, some approaches have implemented learning…
The dynamical properties of a diluted fully-inhibitory network of pulse-coupled neurons are investigated. Depending on the coupling strength, two different phases can be observed. At low coupling the evolution rapidly converges towards…
In this paper we present an efficient model of the neuronal potentials recorded by a deep brain stimulation microelectrode (DBS MER) in the subthalamic nucleus. It is shown that a computationally efficient filtered point process consisting…
We study the noise activated dynamics of a model {\it autapse} neuron system that consists of a subcritical Hopf oscillator with a time delayed nonlinear feedback. The coherence of the noise driven pulses of the neuron exhibits a novel…
One of the most catastrophic neurological disorders worldwide is Parkinson's Disease. Along with it, the treatment is complicated and abundantly expensive. The only effective action to control the progression is diagnosing it in the early…
Effects of synchronization in a system of two coupled oscillators with time-delayed feedback are investigated. Phase space of a system with time delay is infinite-dimensional. Thus, the picture of synchronization in such systems acquires…
Traditional predictive coding networks, inspired by theories of brain function, consistently achieve promising results across various domains, extending their influence into the field of computer vision. However, the performance of the…
Parkinson's disease (PD) is a prevalent neurodegenerative disorder known for its impact on motor neurons, causing symptoms like tremors, stiffness, and gait difficulties. This study explores the potential of vocal feature alterations in PD…
Parkinson's disease (PD) is a neurodegenerative condition characterized by notable motor and non-motor manifestations. The assessment tool known as the Unified Parkinson's Disease Rating Scale (UPDRS) plays a crucial role in evaluating the…
Parkinson's disease is easy to diagnose when it is advanced, but it is very difficult to diagnose in its early stages. Early diagnosis is essential to be able to treat the symptoms. It impacts on daily activities and reduces the quality of…
Feedback delay has been identified as a key ingredient in the quorum sensing synchronization of synthetic gene oscillators. While this influence has been evidenced at the theoretical level in a simplified system of degrade-and-fire…
Parkinson's disease (PD) is a degenerative condition of the nervous system, which manifests itself primarily as muscle stiffness, hypokinesia, bradykinesia, and tremor. In patients suffering from advanced stages of PD, Deep Brain…
Cardiac and respiratory rhythms are known to exhibit a modest degree of phase synchronization, which is affected by age, diseases, and other factors. We study the fine temporal structure of this synchrony in healthy young, healthy elderly,…
Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…
Inhibition is considered to shape neural activity, and broaden its pattern repertoire. In the sensory organs, where the anatomy of neural circuits is highly structured, lateral inhibition sharpens contrast among stimulus properties. The…
Deep learning holds tremendous potential in healthcare for uncovering hidden patterns within extensive clinical datasets, aiding in the diagnosis of various diseases. Parkinson's disease (PD) is a neurodegenerative condition characterized…
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the…
First spike latency following stimulus onset is of significant physiological relevance. Neurons transmit information about their inputs by transforming them into spike trains, and the timing of these spike trains is in turn crucial for…