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In diagnostic studies, researchers frequently encounter imperfect reference standards with some misclassified labels. Treating these as gold standards can bias receiver operating characteristic (ROC) curve analysis. To address this issue,…

Methodology · Statistics 2025-02-13 Yifan Sun , Peijun Sang , Qinglong Tian , Pengfei Li

We study nonparametric maximum likelihood estimation of a log-concave density function $f_0$ which is known to satisfy further constraints, where either (a) the mode $m$ of $f_0$ is known, or (b) $f_0$ is known to be symmetric about a fixed…

Statistics Theory · Mathematics 2019-05-15 Charles R. Doss , Jon A. Wellner

The receiver operating characteristic (ROC) curve is an important graphic tool for evaluating a test in a wide range of disciplines. While useful, an ROC curve can cross the chance line, either by having an S-shape or a hook at the extreme…

Methodology · Statistics 2024-07-02 Soutik Ghosal , Zhen Chen

The optimal receiver operating characteristic (ROC) curve, giving the maximum probability of detection as a function of the probability of false alarm, is a key information-theoretic indicator of the difficulty of a binary hypothesis…

Information Theory · Computer Science 2025-06-10 Bruce Hajek , Xiaohan Kang

In this paper, we study the nonparametric maximum likelihood estimator (MLE) of a convex hazard function. We show that the MLE is consistent and converges at a local rate of $n^{2/5}$ at points $x_0$ where the true hazard function is…

Statistics Theory · Mathematics 2010-01-14 Hanna K. Jankowski , Jon A. Wellner

The accuracy of a diagnostic test is typically characterised using the receiver operating characteristic (ROC) curve. Summarising indexes such as the area under the ROC curve (AUC) are used to compare different tests as well as to measure…

Methodology · Statistics 2010-12-30 Fang Yao , Radu V. Craiu , Benjamin Reiser

To assess the classification accuracy of a continuous diagnostic result, the receiver operating characteristic (ROC) curve is commonly used in applications. The partial area under the ROC curve (pAUC) is one of widely accepted summary…

Applications · Statistics 2011-03-11 Hung Hung , Chin-Tsang Chiang

In this paper we consider the problem of maximizing the Area under the ROC curve (AUC) which is a widely used performance metric in imbalanced classification and anomaly detection. Due to the pairwise nonlinearity of the objective function,…

Machine Learning · Computer Science 2019-06-17 Yunwen Lei , Yiming Ying

The Receiver Operating Characteristic (ROC) is a well-established representation of the tradeoff between detection and false alarm probabilities in binary hypothesis testing. In many practical contexts ROC's are generated by thresholding a…

Statistics Theory · Mathematics 2020-12-16 Catherine Medlock , Alan Oppenheim

The Partial Area Under the ROC Curve (PAUC), typically including One-way Partial AUC (OPAUC) and Two-way Partial AUC (TPAUC), measures the average performance of a binary classifier within a specific false positive rate and/or true positive…

Machine Learning · Computer Science 2022-10-12 Huiyang Shao , Qianqian Xu , Zhiyong Yang , Shilong Bao , Qingming Huang

Methods for the evaluation of the predictive accuracy of biomarkers with respect to survival outcomes subject to right censoring have been discussed extensively in the literature. In cancer and other diseases, survival outcomes are commonly…

Methodology · Statistics 2018-06-06 Yuan Wu , Xiaofei Wang , Jiaxing Lin , Beilin Jia , Kouros Owzar

We propose a likelihood ratio statistic for forming hypothesis tests and confidence intervals for a nonparametrically estimated univariate regression function, based on the shape restriction of concavity (alternatively, convexity). Dealing…

Statistics Theory · Mathematics 2018-09-11 Charles R. Doss

Everybody writes that ROC curves, a very common tool in binary classification problems, should be optimal, and in particular concave, non-decreasing and above the 45-degree line. Everybody uses ROC curves, theoretical and especially…

Methodology · Statistics 2019-08-01 Lidia Sacchetto , Mauro Gasparini

We introduce a new smooth estimator of the ROC curve based on log-concave density estimates of the constituent distributions. We show that our estimate is asymptotically equivalent to the empirical ROC curve if the underlying densities are…

Methodology · Statistics 2023-04-17 Kaspar Rufibach

The Receiver Operating Characteristic (ROC) curve is a useful tool that measures the discriminating power of a continuous variable or the accuracy of a pharmaceutical or medical test to distinguish between two conditions or classes. In…

Methodology · Statistics 2022-07-26 Ana M. Bianco , Graciela Boente , Wenceslao Gonzalez-Manteiga

In this paper, we show the arc length of the optimal ROC curve is an $f$-divergence. By leveraging this result, we express the arc length using a variational objective and estimate it accurately using positive and negative samples. We show…

Statistics Theory · Mathematics 2022-10-19 Song Liu

The assumption of log-concavity is a flexible and appealing nonparametric shape constraint in distribution modelling. In this work, we study the log-concave maximum likelihood estimator (MLE) of a probability mass function (pmf). We show…

Methodology · Statistics 2023-04-17 Fadoua Balabdaoui , Hanna Jankowski , Kaspar Rufibach , Marios Pavlides

The limit distribution of the nonparametric maximum likelihood estimator for interval censored data with more than one observation time per unobservable observation, is still unknown in general. For the so-called separated case, where one…

Statistics Theory · Mathematics 2026-02-12 Piet Groeneboom

Objectives: This study provides an effective model selection method based on the empirical likelihood approach for constructing summary receiver operating characteristic (sROC) curves from meta-analyses of diagnostic studies. Methods: We…

Methodology · Statistics 2018-03-13 ShengLi Tzeng , Chun-Shu Chen , Yu-Fen Li , Jin-Hua Chen

The area under the curve (AUC) of the receiver operating characteristics curve (ROC) evaluates the separation between patients and nonpatients or discrimination. For risk prediction models these risk distributions can be derived from the…

Quantitative Methods · Quantitative Biology 2021-02-23 Ralph H. Stern
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