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High resolution microarrays and second-generation sequencing platforms are powerful tools to investigate genome-wide alterations in DNA copy number, methylation and gene expression associated with a disease. An integrated genomic profiling…

Applications · Statistics 2013-04-22 Ronglai Shen , Sijian Wang , Qianxing Mo

The paper proposes a method for constructing a sparse estimator for the inverse covariance (concentration) matrix in high-dimensional settings. The estimator uses a penalized normal likelihood approach and forces sparsity by using a…

Statistics Theory · Mathematics 2008-06-26 Adam J. Rothman , Peter J. Bickel , Elizaveta Levina , Ji Zhu

Within the statistical and machine learning literature, regularization techniques are often used to construct sparse (predictive) models. Most regularization strategies only work for data where all predictors are treated identically, such…

Computation · Statistics 2020-12-16 Sander Devriendt , Katrien Antonio , Tom Reynkens , Roel Verbelen

This paper addresses classification problems with matrix-valued data, which commonly arise in applications such as neuroimaging and signal processing. Building on the assumption that the data from each class follows a matrix normal…

Methodology · Statistics 2025-12-18 Seungyeon Oh , Seongoh Park , Hoyoung Park

We formulate the sparse classification problem of $n$ samples with $p$ features as a binary convex optimization problem and propose a cutting-plane algorithm to solve it exactly. For sparse logistic regression and sparse SVM, our algorithm…

Optimization and Control · Mathematics 2025-01-08 Dimitris Bertsimas , Jean Pauphilet , Bart Van Parys

Mixtures of matrix Gaussian distributions provide a probabilistic framework for clustering continuous matrix-variate data, which are becoming increasingly prevalent in various fields. Despite its widespread adoption and successful…

Computation · Statistics 2023-07-21 Andrea Cappozzo , Alessandro Casa , Michael Fop

This paper develops an approach to inference in a linear regression model when the number of potential explanatory variables is larger than the sample size. The approach treats each regression coefficient in turn as the interest parameter,…

Methodology · Statistics 2022-11-14 Heather S. Battey , Nancy Reid

For some special data in reality, such as the genetic data, adjacent genes may have the similar function. Thus ensuring the smoothness between adjacent genes is highly necessary. But, in this case, the standard lasso penalty just doesn't…

Methodology · Statistics 2022-09-29 Xin Xin , Boyi Xie , Yunhai Xiao

We propose a compressive classification framework for settings where the data dimensionality is significantly higher than the sample size. The proposed method, referred to as compressive regularized discriminant analysis (CRDA) is based on…

Machine Learning · Statistics 2020-11-13 Muhammad Naveed Tabassum , Esa Ollila

In this work we suggest a statistical mechanics approach to the classification of high-dimensional data according to a binary label. We propose an algorithm whose aim is twofold: First it learns a classifier from a relatively small number…

Statistical Mechanics · Physics 2009-07-22 Andrea Pagnani , Francesca Tria , Martin Weigt

Molecular profiling data (e.g., gene expression) has been used for clinical risk prediction and biomarker discovery. However, it is necessary to integrate other prior knowledge like biological pathways or gene interaction networks to…

Genomics · Quantitative Biology 2016-09-22 Wenwen Min , Juan Liu , Shihua Zhang

Quadratic discriminant analysis (QDA) is a standard tool for classification due to its simplicity and flexibility. Because the number of its parameters scales quadratically with the number of the variables, QDA is not practical, however,…

Methodology · Statistics 2018-09-06 Binyan Jiang , Xiangyu Wang , Chenlei Leng

We describe a fast method to eliminate features (variables) in l1 -penalized least-square regression (or LASSO) problems. The elimination of features leads to a potentially substantial reduction in running time, specially for large values…

Machine Learning · Computer Science 2011-05-19 Laurent El Ghaoui , Vivian Viallon , Tarek Rabbani

Many sparse linear discriminant analysis (LDA) methods have been proposed to overcome the major problems of the classic LDA in high-dimensional settings. However, the asymptotic optimality results are limited to the case that there are only…

Statistics Theory · Mathematics 2015-08-06 Ruiyan Luo , Xin Qi

We consider a Gaussian sequence space model $X_{\lambda}=f_{\lambda} + \xi_{\lambda},$ where $\xi $ has a diagonal covariance matrix $\Sigma=\diag(\sigma_\lambda ^2)$. We consider the situation where the parameter vector $(f_{\lambda})$ is…

Statistics Theory · Mathematics 2013-12-23 Laurent Cavalier , Markus Reiß

Feature selection from a large number of covariates (aka features) in a regression analysis remains a challenge in data science, especially in terms of its potential of scaling to ever-enlarging data and finding a group of scientifically…

Machine Learning · Statistics 2020-02-10 Yiying Fan , Jiayang Sun

Linear discriminant analysis (LDA) is a typical method for classification problems with large dimensions and small samples. There are various types of LDA methods that are based on the different types of estimators for the covariance…

Methodology · Statistics 2023-03-07 Jaehoan Kim , Hoyoung Park , Junyong Park

Penalized regression models such as the Lasso have proved useful for variable selection in many fields - especially for situations with high-dimensional data where the numbers of predictors far exceeds the number of observations. These…

Methodology · Statistics 2014-03-19 Kasper Brink-Jensen , Claus Thorn Ekstrøm

We propose a new method of learning a sparse nonnegative-definite target matrix. Our primary example of the target matrix is the inverse of a population covariance or correlation matrix. The algorithm first estimates each column of the…

Statistics Theory · Mathematics 2013-10-15 Tingni Sun , Cun-Hui Zhang

The popular Lasso approach for sparse estimation can be derived via marginalization of a joint density associated with a particular stochastic model. A different marginalization of the same probabilistic model leads to a different…

Machine Learning · Statistics 2013-02-28 Aleksandr Y. Aravkin , James V. Burke , Alessandro Chiuso , Gianluigi Pillonetto