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Identifying disease genes from human genome is an important and fundamental problem in biomedical research. Despite many publications of machine learning methods applied to discover new disease genes, it still remains a challenge because of…

Quantitative Methods · Quantitative Biology 2017-05-23 Peng Yang

Recent advances in cancer research largely rely on new developments in microscopic or molecular profiling techniques offering high level of detail with respect to either spatial or molecular features, but usually not both. Here, we present…

Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

Methodology · Statistics 2012-01-30 Alberto Cozzini , Ajay Jasra , Giovanni Montana

Breast cancer is a relatively common cancer among gynecological cancers. Its diagnosis often relies on the pathology of cells in the lesion. The pathological diagnosis of breast cancer not only requires professionals and time, but also…

Image and Video Processing · Electrical Eng. & Systems 2024-04-15 MingXuan Xiao , Yufeng Li , Xu Yan , Min Gao , Weimin Wang

Gene selection plays a pivotal role in oncology research for improving outcome prediction accuracy and facilitating cost-effective genomic profiling for cancer patients. This paper introduces two gene selection strategies for deep…

Genomics · Quantitative Biology 2024-03-05 Akhila Krishna , Ravi Kant Gupta , Pranav Jeevan , Amit Sethi

Deep learning has become the mainstream methodological choice for analyzing and interpreting whole-slide digital pathology images (WSIs). It is commonly assumed that tumor regions carry most predictive information. In this paper, we…

Quantitative Methods · Quantitative Biology 2022-04-26 Zihan Chen , Xingyu Li , Miaomiao Yang , Hong Zhang , Xu Steven Xu

Classifications organize entities into categories that identify similarities within a category and discern dissimilarities among categories, and they powerfully classify information in support of analysis. We propose a new classification…

Optimization and Control · Mathematics 2022-09-05 Casey Garner , Allen Holder

Linear discrimination, from the point of view of numerical linear algebra, can be treated as solving an ill-posed system of linear equations. In order to generate a solution that is robust in the presence of noise, these problems require…

Genomics · Quantitative Biology 2007-05-23 Erik Andries , Thomas Hagstrom , Susan R. Atlas , Cheryl Willman

Breast cancer is a heterogeneous disease with different molecular subtypes, clinical behavior, treatment responses as well as survival outcomes. The development of a reliable, accurate, available and inexpensive method to predict the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Mohaddeseh Chegini , Ali Mahloojifar

Label learning is a fundamental task in machine learning that aims to construct intelligent models using labeled data, encompassing traditional single-label and multi-label classification models. Traditional methods typically rely on…

Machine Learning · Computer Science 2025-11-11 Chenxi Luoa , Zhuangzhuang Zhaoa , Zhaohong Denga , Te Zhangb

Detection and segmentation of Brain tumor is very important because it provides anatomical information of normal and abnormal tissues which helps in treatment planning and patient follow-up. There are number of techniques for image…

Computer Vision and Pattern Recognition · Computer Science 2012-12-04 Minakshi Sharma

Our goal in this paper is to automatically extract a set of decision rules (rule set) that best explains a classification data set. First, a large set of decision rules is extracted from a set of decision trees trained on the data set. The…

Neural and Evolutionary Computing · Computer Science 2022-09-19 Paul-Amaury Matt , Rosina Ziegler , Danilo Brajovic , Marco Roth , Marco F. Huber

Traditionally, signal classification is a process in which previous knowledge of the signals is needed. Human experts decide which features are extracted from the signals, and used as inputs to the classification system. This requirement…

Neural and Evolutionary Computing · Computer Science 2019-04-11 Daniel Rivero , Enrique Fernandez-Blanco , Julian Dorado , Alejandro Pazos

Federated learning enables collaborative training of deep learning models across institutions without sharing sensitive patient data. However, its performance is often limited by small datasets and non-independent, identically distributed…

Image and Video Processing · Electrical Eng. & Systems 2026-04-17 Hongyi Pan , Ziliang Hong , Gorkem Durak , Ziyue Xu , Ulas Bagci

On the basis of network analysis, and within the context of modeling imprecision or vague information with fuzzy sets, we propose an innovative way to analyze, aggregate and apply this uncertain knowledge into community detection of…

Statistics Theory · Mathematics 2024-02-08 Inmaculada Gutiérrez , Daniel Gómez , Javier Castro , Rosa Espínola

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel

The diagnosed cases of Breast cancer is increasing annually and unfortunately getting converted into a high mortality rate. Cancer, at the early stages, is hard to detect because the malicious cells show similar properties (density) as…

Computer Vision and Pattern Recognition · Computer Science 2017-04-13 Deepti Ameta

With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new…

Quantitative Methods · Quantitative Biology 2020-07-03 Thomas Gaudelet , Noel Malod-Dognin , Natasa Przulj

Skin cancer is the most common human malignancy(American Cancer Society) which is primarily diagnosed visually, starting with an initial clinical screening and followed potentially by dermoscopic(related to skin) analysis, a biopsy and…

Image and Video Processing · Electrical Eng. & Systems 2022-02-03 Kartikeya Agarwal , Tismeet Singh

Motivated by applications in high-dimensional data analysis where strong signals often stand out easily and weak ones may be indistinguishable from the noise, we develop a statistical framework to provide a novel categorization of the data…

Methodology · Statistics 2013-05-02 X. Jessie Jeng