Related papers: A Quantitative Method for Estimating the Human Dev…
Many theories have been proposed to answer two questions on aging: "Why do we age?" and "How do we age?" Among them, evolutionary theories are proposed to interpret the evolutionary advantage of aging, and "saving resources for group…
Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex…
Human motion detection is getting considerable attention in the field of Artificial Intelligence (AI) driven healthcare systems. Human motion can be used to provide remote healthcare solutions for vulnerable people by identifying particular…
The Gompertz law of mortality quantitatively describes the mortality rate of humans and almost all multicellular animals. However, its underlying kinetic mechanism is unclear. The Gompertz law cannot explain the effect of temperature on…
Aimed at the timely detection of the degradation of electrical machines and the organization of active maintenance, numerous studies on performance degradation assessment have been conducted. However, previous research still suffers from…
The ageing intensity function is a powerful analytical tool that provides valuable insights into the ageing process across diverse domains such as reliability engineering, actuarial science, and healthcare. Its applications continue to…
Recent years have witnessed an increasing global population affected by neurodegenerative diseases (NDs), which traditionally require extensive healthcare resources and human effort for medical diagnosis and monitoring. As a crucial…
We formulate a general, high-dimensional kinetic theory describing the internal state (such as gene expression or protein levels) of cells in a stochastically evolving population. The resolution of our kinetic theory also allows one to…
The focus on managing problems that can arise for older adults has meant that extant HCI and Ageing research has not given the concepts of 'age' and 'ageing' the explicit theoretical attention they deserve. Attending to this gap, we…
Advances in healthcare and in the quality of life significantly increase human life expectancy. With the ageing of populations, new un-faced challenges are brought to science. The human body is naturally selected to be well-functioning…
In the Staged Progression (SP) epidemic models, infected individuals are classified into a suitable number of states. The goal of these models is to describe as closely as possible the effect of differences in infectiousness exhibited by…
As global population aging intensifies, there is growing interest in the study of biological age. Bones have long been used to evaluate biological age, and the decline in bone density with age is a well-recognized phenomenon in adults.…
Multivariate functional data present theoretical and practical complications which are not found in univariate functional data. One of these is a situation where the component functions of multivariate functional data are positive and are…
Sit-to-stand transitions are an important part of activities of daily living and play a key role in functional mobility in humans. The sit-to-stand movement is often affected in older adults due to frailty and in patients with motor…
Previously we have developed the concept of the dynamic pathosome, which suggests that individual patterns of phenotype development, i.e., phenotypic trajectories, contain more information than is commonly appreciated and that a phenotype's…
Reliable methods for the neurodevelopmental assessment of infants are essential for early detection of problems that may need prompt interventions. Spontaneous motor activity, or 'kinetics', is shown to provide a powerful surrogate measure…
Accurately predicting chronological age from DNA methylation patterns is crucial for advancing biological age estimation. However, this task is made challenging by Epigenetic Correlation Drift (ECD) and Heterogeneity Among CpGs (HAC), which…
Digital health technologies enable high-frequency collection of data in near-continuous time and capture rich information about the health of individuals. The raw data collected by these devices often have a hierarchical functional…
This article proposes an age-structured compartment model for irreversible diseases with a pre-clinical state of undiagnosed cases that precedes the diagnosis. The model is able to cope with mortality rates differing between the…
Due to the widespread availability of effective antiretroviral therapy (ART) regimens, average lifespans of persons with HIV (PWH) in the United States have increased significantly in recent decades. In turn, the demographic profile of PWH…